We develop and employ high-resolution methods to study Biology where it happens: In Cells
Weizmann Institute of Science
Joined December 2018
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Just a quick update. Everyone in the lab has been brought to safety. All internationals are evacuated. We regroup online to move forward. We'll be back! 🇮🇱
These are hard times. We feel your sorrow and we share your grieve. We shall stand strong together! 🇮🇱
This was a panel discussion on the future of Structural Biology. Age of participants: KW 84, JF 83, JD 79, HM 74. Moderator WL 74. Any question? science.org/content/article/…
Who is going to lead the way? More such efforts are needed. The future of Structural Biology is in the cell!
Great to see Philipp Selenko from @WeizmannScience highlighting our @wellcometrust cellular structural biology DTP as an exemplar for the future needs of cellular bioimaging at the @iNEXT_Discovery user meeting in Budapest #bioimaging
Fun facts about the Physics of Biology … but indulge with caution > numbers likely represent boundary limits as they predate (some of the more) modern concepts and quantifications. But you get the point; Cells are amazing!
Cells are very fast and crowded places.
A molecule of glucose flies through a cell at 250 mph.
A protein tumbles 60 million times per minute.
These numbers seem made up. How did we figure this stuff out?
ALT Acknowledgement: Martina Maritan, Ludovic Autin, David S. Goodsell, Scripps Research and RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-040
Exciting times for Cellular Structural Biology! Mark this announcement👇
In collaboration with the @rbolab, we are pleased to present AlphaLink2 - a modified version of AlphaFold-Multimer that is capable of directly incorporating experimental residue-residue contact data from crosslinking MS (and potentially other techniques as well). (1/7)
President and Vice President … this is what strong leadership & good governance looks like
@WeizmannScience president Alon Chen and VP Ziv Reich out to demonstrate in support of arrested scientist @ShikmaBressler
Yet another visual reminder of how tensely packed the (bacterial) cytoplasm really is. An impediment to biological fidelity? Far from it. Cellular confinement > probably THE biggest success story in evolution.
I can now load _basically_ every atom from an entire bacterial cell, into #blender3d and #geometrynodes via #molecularnodes. Each macromolecule is down to atomic detail where available via CellPack, totalling ~250,000,000 points, all rendering (quite quickly) in Cycles #b3d
ALT A 3D rendering of the inside of a Mycoplasma Genitaliam cell, which has been vertically sliced to show the proteins and DNA that are inside the cell. The sliced cell is on a pink background with soft lighting, and it floats atop a reflective surface.
While many may think that I reviewed this MS (especially if you read the reviewers' comments) ... I didn't. If I had, I'd done it differently. IMO, a lot in this paper is beside the point 🤷♂️
An improved method for in-cell NMR is developed using a reporter to evaluate protein delivery and delivery parameters to different cell lines and applied to IDPs and folded proteins including structure determination of GB1 at 1.1 Å resolution.
nature.com/articles/s42003-0…
