PI at Vanderbilt University. See @karihoffman@neuromatch.social
Nashville, TN
Joined March 2015
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Humor me: I’m reactivating the latest preprint from the lab (itza “new” trace) 🤓
Experience reorganizes content-specific memory traces in macaques 🐒🧠. @perpl_lab @AymanAljishi
tinyurl.com/Perpllab-react
Latest paper from the lab!
How does the brain incorporate new experiences without disrupting older memories?
In our new @NatureNeuro paper, we show that experience reorganizes memory-related neural activity in macaques during both waking and overnight sleep. 1/19
Kari Hoffman retweeted
Multi-Neuromodulatory fingerprints of an adaptive cognitive state: Cognitive engagement was predicted by joint GABA & ACh/Choline in PFC; by Dopamine & Cholinergic changes in striatum. Glutamate & ACh correlated across states. Kudos to team + Dr Pawliszyn biorxiv.org/content/10.64898…
Kari Hoffman retweeted
2/2 Abilities of inhibitory control, WM updating, and shifting distinguished cognitive phenotypes in NHP's; expl. factor analysis suggested 1) WM updating 2) Shifting/Learning, and 3+4) inhibitory control of interference from external vs internal sources are 4 sep. cogn. factors.
Kari Hoffman retweeted
New paper shows causal effects of gaze-contingent stimulation on learning feature-based attention: Treuting et al. (2025) Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum. Neuron cell.com/neuron/fulltext/S08…
1/2
Kari Hoffman retweeted
Experience reorganizes content-specific memory traces in macaques 🐒🧠. @perpl_lab @AymanAljishi
tinyurl.com/Perpllab-react
Kari Hoffman retweeted
🌟 Cai Lab @Nature paper alert! In new work led by @mysteriousjoe_, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/9)
Read it here: nature.com/articles/s41586-0…
Kari Hoffman retweeted
I am and have been fascinated with how memories are formed and stored. A big challenge, not unique to memory, is synthesizing concepts across scales of anaylsis - from molecules to computation. Here I try to distill how we can move forward in understanding memories. Thanks /1
Jason Shepherd @JasonSynaptic asks eight scientists to weigh in on what makes memories last—dynamic ensembles or static synapses?
thetransmitter.org/the-big-p…
What makes memories last—dynamic ensembles or static synapses? | The Transmitter: Neuroscience News and… disq.us/t/4r3afea Thanks to @JasonSynaptic for organizing!
Come to U10 U11 this morning if you’re interested in NHP cell assemblies, memory replay, wireless recording 100s of units during learning of new and old context-specific sequences, all in freely moving (and sleeping) monkeys #sfn2024
Kari Hoffman retweeted
New research from @perpl_lab sheds light on the circuit organization that supports memory and spatial cognition. 🧠 This discovery helps with our understanding of how our brains process complex cognitive tasks.
🔗 Read the full study here 👉
cell.com/cell-reports/fullte…
Kari Hoffman retweeted
New Paper in @CurrentBiology! Chimpanzees across FIVE communities take rapid turns in gesture-to-gesture exchanges resembling human conversational patterns. Language may not be a pre-requisite for fast-paced, coordinated communication in social species sciencedirect.com/science/ar…
Kari Hoffman retweeted
Women are consistently under-cited in neuroscience. @anne_churchlandand and @FDavatolhagh share tools that can help assess citation diversity.
thetransmitter.org/publishin…
Kari Hoffman retweeted
Cortical interneurons learn on the job! Speculated this was true a decade ago! @JJSherryWU and @artofbiology finally provide evidence! biorxiv.org/content/10.1101/…
Kari Hoffman retweeted
Monumental new work from the @GeorgeDragoi2 lab tackles the question of how replay can parallelize, bind, and compress representations of 15 (!) unique linear track experiences: nature.com/articles/s41593-0…
Kari Hoffman retweeted
✨Check out Animations in #SilicoStudio! Add seamless animations with interactive triggers to create stunning and immersive Experiences. Transform your projects with fluid motion and engaging visuals.
#Innovation #Technology #XR #Interactive #Animations
Kari Hoffman retweeted
Excited to see this out @NeuroCellPress: authors.elsevier.com/a/1jRiE… We report on a meeting about internal world models in humans, animals, and AI putting Marr's three levels into action across species. @UniFreiburg @IMBIT_UniFR @BrainworldsFR @ThomasBrox @VlachosLab @m_schoenauer
Beautiful. We need more of this! Also newer Kilosort v’s created some issues as it solved others- @SAbbaspoor applied a system of manual curation after KS here; cell.com/cell-reports/fullte…
3/3 c) Pay attention to spike sorter versions! Critics deemed our data "low quality" b/c neuron yields were lower than other studies. We dug deep. Turns out difference was due to use of different spike sorting versions. 🤯Paper now submitted to @eLife. biorxiv.org/content/10.1101/…
This is the first large-animal paper using all DBC deep array probes, but won’t be the last. If you’re into high density sampling (eg #neuropixels, scrolls, etc), and are considering good options for deep/indwelling/wireless/linear recordings, feel free to reach out!
Cell Press published the research from @perpl_lab where Sam Abbaspoor and Kari Hoffman utilized the DBC Deep Array to uncover the macaque hippocampus's unique circuit dynamics govern navigation, memory, and social behaviors across species. hubs.ly/Q02H7G2d0 #DBCInside
