@path_putra

Pediatric Pathologist @BostonChildrens Assistant Professor of Pathology @harvardmed

 Boston, MA
researchgate.net/profile/Juan-Putra
Joined June 2021
  • Tweets41
  • Following328
  • Followers434
9Media
Unexpected opening! One spot available for Pediatric Pathology Fellowship at Boston Children’s Hospital for 2026-2027. Join our team and help shape the future of pediatric pathology. Message me for further details. @SocPediPath @AlyaaIbraheemi @AlannaChurch_MD @jake_bledsoe
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Dinner with superstars in vascular anomalies in New Orleans; missing @AnitaGuPath
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🚨 Open Access Content Alert!🚨 What makes evaluating pediatric acute liver failure different from liver failure in adults? When do kids need a liver biopsy for acute liver failure? Find out here (Open access until November 4th): journals.sagepub.com/doi/ful… #PediPath #GIpath
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A young patient with elevated liver enzymes @SocPediPath #pathology #PathTwitter #pedipath #GIpath #liverpath
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This condition is associated with mutations of which gene
51%SERPINA1
18%LIPA
21%FGG
10%GBA
78 votes • Final results
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Answer: FIBRINOGEN STORAGE DISEASE (fibrinogen gene mutation, incl. FGG). The globular inclusions are present throughout (panlobular); while, A1AT deficiency is more pronounced in zone 1 hepatocytes. EM shows tubular inclusions in a fingerprint pattern.
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Classic #pedipath #GIpath Abetalipoproteinemia: Congenital enteropathy due to MTTP mutation. Duodenal bx shows prominent fat vacuoles in the apical villous cytoplasm with preserved architecture. Others: acanthocytes on blood smear, hepatic steatosis. @SocPediPath #PathTwitter
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A teenager with sickle cell trait and a 3.0 cm mass in the renal pelvis #PediPath #gupath #pathology #PathTwitter #pathresidents @SocPediPath
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The lesion is associated with alteration of which gene
51%SMARCB1
31%ALK
15%TFE3
4%TFEB
169 votes • Final results
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Answer: VCL-ALK renal cell carcinoma This subtype of RCC is associated with younger patients, sickle cell trait, renal pelvis involvement, and intact INI1. (PMIDs: 24698962, 26773439) H&E: discohesive, polygonal cells with cytoplasmic vacuoles, ALK IHC: focal membranous staining
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Happy Friday! This is a 3 y.o. boy with rectal bleeding. Thoughts? @DoktoraMalvar @SocPediPath @navale_pooja @BerkliteLara @GIJamesMD #pathtwitter #gipath #pedipath #pathology
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Answer: chronic granulomatous disease. Along with granulomas, pigmented macrophages are a feature of CGD. The pigment represents a by-product ineffective digestion of organisms, membranes, and lipid. Other features: eosinophilia, activity, and chronic changes (PMID: 23887163).
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Classic Pedi Path. Cardiac tumor of an infant. @SocPediPath @GSomersPath @MArnold_PedPath @DHPathRes @sm_armstrong8 @VHNguyenMD #PathTwitter #pedipath #pathology #pathresidents
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This lesion is associated with mutations of which gene(s)?
13%PTCH1
70%TSC1/TSC2
17%PRKAR1A
63 votes • Final results
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The H&Es show spider cells characteristic of CARDIAC RHABDOMYOMA. It is considered a hamartoma of developing cardiomyocytes and associated with tuberous sclerosis (TSC1/2 mutations). Others: Cardiac fibroma - Gorlin syndrome (PTCH1) Cardiac myxoma - Carney complex (PRKAR1A)
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First tweet - Here we go.. Biopsy of a hepatic mass in a teenager (IHC1-WT1, IHC2-b-catenin). Any guesses? @navale_pooja @liverwei @CharlottesWebMD @dgbrackett @SocPediPath #pathology #PathTwitter #pedipath #GIpath #liverpath
WT1

ALT WT1

Beta-catenin

ALT Beta-catenin

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Note how the nest is composed of spindle cells in the periphery and round cells in the center. The cells are positive for WT1 (N-terminus). The lesion is associated with CTNNB1 and TERT promoter alterations (PMID: 33994539). Ddx/ hepatoblastoma and DSRCT (+ for WT1 C-terminus).
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Answer: calcifying nested stromal-epithelial tumor (CNSET). Despite the name, calcifications are not required to make the diagnosis. H&E - biphasic tumor with nests of bland-appearing round and spindle cells and variably cellular myofibroblastic stroma.
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