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¿Los inhibidores de bomba de protones (IBP) realmente causan daño renal?
Abro hilo 🧵 x/10
Pablo Angeles Tacchino retweeted
En nefropatía por IgA y proteinuria, atacicept, sibeprenlibam y telitacicept, al compararse con comparado a placebo; evitaron la ↓TFGe , logrando alcanzar la reducción fisiológica de TFGe
En los ensayos clínicos ORIGIN, VISIONARY y TELIGAN
Impresionantes resultados que hacen pensar en la remisión completa y sostenida de esta patología
Pablo Angeles Tacchino retweeted
Replying to @ASNKidney
@ASNKidney President’s Award goes to Will Flanary. “Cardiology never gave me an award” . Well deserved. #KidneyWk
Pablo Angeles Tacchino retweeted
During his Presidents Award speach, @DGlaucomflecken talks about his experience and more importantly his wife's experience following his cardiac arrest. Advising people to show compassion to the co-survivors, the family.
Pablo Angeles Tacchino retweeted
#KidneyWk
VISIONARY IgAN Phase 3 (sibeprenlimab update) with @DanaRizk1
24 mo outcomes and safety-
eGFR: +1.3 vs -7.9 (placebo)
Composite kidney outcome: 1 /259 bs 28/251 (placebo)
No patients in sibe group had dbl SCr or needed dialysis
AE primarily URI
Simultaneous in @NEJM
Pablo Angeles Tacchino retweeted
Joel was one of my first twitter follows when I started Glaucomflecken 10 years ago. I’ve learned so much from him, like how to say osmolality. Still working out what exactly it is, but at least I can pronounce it.
During his Presidents Award speach, @DGlaucomflecken talks about his experience and more importantly his wife's experience following his cardiac arrest. Advising people to show compassion to the co-survivors, the family.
Pablo Angeles Tacchino retweeted
More on previously published interim analysis of TELIGAN trial by #nephjc
@DrAkshayaJ
nephjc.com/news/2026/short/t…
Pablo Angeles Tacchino retweeted
Replying to @IgAN_JBarratt
@IgAN_JBarratt presenting the final results of ORIGIN trial #KidneyWk
Atacicept in IgAN
#NephJC reminder of previously published results: nephjc.com/news/atacicept-or…
Pablo Angeles Tacchino retweeted
Next to LBCT #kidneywk @DanaRizk1 on VISIONARY trial 24 months results
See #NephJC write up on previously published results
nephjc.com/news/2025/11/8/ki…
Pablo Angeles Tacchino retweeted
What a moment at #KidneyWk @DGlaucomflecken receiving this years President's Medal
And he gives a huge shout out to @kidney_boy @NephJC #Homeostasis
And yes Morton Salt has appeared.
Kudos to @ASNKidney
Pablo Angeles Tacchino retweeted
and the conclusion #KidneyWk
Pablo Angeles Tacchino retweeted
4/ ⚠️Not all congestion is the same!
#KidneyWk
📍LV diastolic dysfunction: ⬆️ filling pressures can cause pulmonary congestion
🦠Sepsis: vasodilation can lower blood pressure even when filling pressures are elevated
🫀Right heart failure: systemic venous congestion may occur without pulmonary congestion
Pablo Angeles Tacchino retweeted
2/Can the jugular vein help estimate right atrial pressure (RAP)? #KidneyWk
👉IJV height: Find where the vein collapses (the wine bottle sign). Its vertical height helps estimate RAP
👉IJV collapsibility: Assess how the vein changes with breathing
👉Valsalva maneuver: A smaller increase in IJV cross-sectional area may suggest elevated RAP
Pablo Angeles Tacchino retweeted
5/ When is an AV fistula mature? #KidneyWk
⚠️The traditional rule of 6s (>6 mm diameter, <6 mm depth, >600 mL/min flow) is being challenged
⚠️The slide proposes lower thresholds: 5 mm diameter and >500 mL/min flow
Pablo Angeles Tacchino retweeted
Los IBP (ej. omeprazol) se asociaron a ↑2.5 veces el riesgo de desarrollar hiponatremia severa (Na <125 mEq/L), sobre todo en las primeras 3 semanas del inicio
Hipótesis: induce SIHAD y/o hipomagnesemia que influye en la bomba Na/K ATPasa
Kidney360 2026
10.34067/KID.0000001412
Pablo Angeles Tacchino retweeted
✅ Renal POCUS: SECONDS checklist #KidneyWk
@JaberiAala @NephroP
✅A systematic approach to kidney ultrasound:
☑️S – Size: Assess kidney length and cortical thickness.
☑️E – Echogenicity: Compare renal cortex with the liver or spleen
☑️C – Collecting system: Look for hydronephrosis and urinary tract dilation
☑️O – Outline: Check renal contours for irregularities or masses
☑️N – Notable lesions: Identify cysts, stones, or focal abnormalities
☑️D – Doppler: Assess renal perfusion and vascular abnormalities
☑️S – Surroundings: Look for perinephric collections or other adjacent abnormalities
Pablo Angeles Tacchino retweeted
🩵📧 Kidney Week moves fast... let us keep you in the loop!
Subscribe to the #NephJC newsletter for event updates, highlights, and all the nephrology fun headed your way during #KidneyWk
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