@ot_chip

🦠🔬 PhD Candidate in the Mougous Lab at Yale interested in intermicrobial interactions

Joined September 2021
  • Tweets86
  • Following290
  • Followers109
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Otto Chipashvili retweeted
Billy Ngo@billymngoApr 5
Been building a genomics viewer with Claude Code for diverse genomic data (TnSeq, RNASeq etc) It’s intuitive, light, and highly customizable for figures or .svg files. If you’ve been looking for an IGV alternative check it out! Run “pip install bingoviewer” then “bingo”
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Otto Chipashvili retweeted
Cell@CellCellPress3 Dec 2025
Now online! The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for interbacterial antagonism dlvr.it/TPcVMb

The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for...

Umbrella toxin particles produced by Actinobacteria contain five spokes tipped with variable lectin domains. Here, Zhao et al. show that these lectins mediate species-specific binding to a previously...

cell.com
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Pseudomonads on GAURD Mougous @YaleMicroPath describe immune strategy in Pseudomonas, termed GUARD, that protects against bacteria & viruses. Controlled by Gac/Rsm regulatory pathway, program activates suite of defense mechanisms to general danger signal cell.com/cell-host-microbe/f…
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BetaH proteolysis unleashes an electrostatic-homing antibacterial polymorphic toxin biorxiv.org/content/10.1101/… #biorxiv_micrbio

BetaH proteolysis unleashes an electrostatic-homing antibacterial polymorphic toxin

Contact-dependent or diffusible proteinaceous polymorphic toxin systems (PTSs) mediate widespread bacterial competition. While bioinformatic analyses have identified diverse PTSs across bacterial...

biorxiv.org
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who needs Adobe Illustrator when MS Paint still exists?
Cell@CellCellPress27 Jul 2025
In the latest issue! Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes dlvr.it/TM8GVY
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Recognition of unique cell surface glycopolymers by diversified lectin domains specifies umbrella toxin targeting biorxiv.org/content/10.1101/… #biorxiv_micrbio

Recognition of unique cell surface glycopolymers by diversified lectin domains specifies umbrella...

The bacterial cell envelope provides structural integrity and is an essential conduit through which the organism interacts with its environment. However, the molecular structures of its constituents...

biorxiv.org
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Twists, turns and jumps: T6SS evolution within species dlvr.it/TJTwgC
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We are delighted to welcome Joseph Mougous to the Microbial Sciences Institute. An international leader in microbiology and HHMI Investigator, Mougous joins the faculty @YaleMicroPath later this year. medicine.yale.edu/news-artic…

Joseph Mougous Joins Department of Microbial Pathogenesis

Joseph Mougous, an international leader in microbiology and Howard Hughes Medical Institute Investigator, is bringing his lab to Yale School of Medicine.

medicine.yale.edu
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Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system biorxiv.org/content/10.1101/… #biorxiv_micrbio

Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system

Bacterial cells live under the constant existential threats imposed by other bacteria and viruses. Their mechanisms for contending with these threats are well documented; however, the regulation of...

biorxiv.org
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Otto Chipashvili retweeted
Patrick Collison
@patrickc16 Feb 2025
Biology papers be like "The nucleus is part of the cell and contains a lot of DNA. Polycomb Repressive Complex 2 (PRC2)-mediated deposition of H3K27me3 establishes domains of facultative heterochromatin, silencing gene expression in a developmentally regulated manner."
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🎯 Do you really understand p-values? The p-value histogram can reveal a LOT about your data. Let's break it down using real examples.👇
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The enigmatic, ultrasmall and largely uncultivated Candidate Phyla Radiation bacteria represent a treasure trove of potential discoveries, argues this recent Perspective in PNAS🕵️👇 from the Mougous Lab @UW pnas.org/doi/10.1073/pnas.24…

Beyond genomics in Patescibacteria: A trove of unexplored biology packed into ultrasmall bacteria |...

Patescibacteria, also known as the Candidate Phyla Radiation, are a diverse clade of largely uncultivated, small bacteria that comprise a significa...

pnas.org
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New review on the 'microbial dark matter' that is Patescibacteria pnas.org/doi/10.1073/pnas.24…

Beyond genomics in Patescibacteria: A trove of unexplored biology packed into ultrasmall bacteria |...

Patescibacteria, also known as the Candidate Phyla Radiation, are a diverse clade of largely uncultivated, small bacteria that comprise a significa...

pnas.org
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Bulky pastas—like farfalle and fusilli—require more packaging than thinner varieties, making them trickier to transport and leading to more waste. 🍝 On #NationalPastaDay, learn more about a different twist on pasta dough that could help reshape food manufacturing, according to a @ScienceAdvances study. bit.ly/4dQFHhB
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Otto Chipashvili retweeted
The Nobel Prize
@NobelPrize9 Oct 2024
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Otto Chipashvili retweeted
Itai Yanai
@ItaiYanai6 Oct 2024
Doing good science is 90% finding a science buddy to constantly talk to about the project.
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Otto Chipashvili retweeted
alex meeske@alexjmeeske4 Sep 2024
The final version of our paper on anti-CRISPRs "in disguise" as Cas proteins is out today in Nature! Congrats to Mark, Edith and the whole team! nature.com/articles/s41586-0…
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one of my favorites is the paper that just put in a capital T for error bars
This Post is from an account that no longer exists. Learn more
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This is so good!
Tim Davison ᯅ
@timd_ca16 Aug 2024
We’re thrilled to announce CellWalk for iPhone and iPad! 📱✨ Journey to the atomic level and explore the molecular machines of a bacterial cell. We’re building the future of biology education—it’s interactive and immersive. apps.apple.com/us/app/cellwa… #Apple #iPhone #iPad #scicomm #BiologyApp #STEM #EdTech #gamedev
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This is what one year of PhD thesis work looks like. All hail the Tapeball.
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