Husband & wife PhD duo working on single-cell epigenomics at Oregon Health & Science University with @acadey80. Ruth maintains the account.
Portland, OR
Joined May 2020
- Tweets46
- Following107
- Followers73
- Likes108
It's been a while, but we published sciMETv3 in @CellGenomics in the beginning of this year!! cell.com/cell-genomics/fullt…
50
Ruth V. Nichols & Brendan L. O'Connell retweeted
Atlas-scale Single-cell DNA Methylation Profiling with sciMETv3 biorxiv.org/cgi/content/shor… #biorxiv_genetic
Ruth V. Nichols & Brendan L. O'Connell retweeted
Single-cell DNA methylation analysis tool Amethyst reveals distinct noncanonical methylation patterns in human glial cells biorxiv.org/cgi/content/shor… #biorxiv_neursci
Very excited that @acadey80 presented on sciMETv3 at #AGBT24 ! I am very proud to say that I (Ruth) am the lead on this :)
sciMET v3, an interesting method for large-scale single-cell methylation study presented by Andrew Adey. Using combinatorial indexing and methyl region capture they can now generate meth profile for 10^5 cells. #AGBT24
4
216
This new kit is based off our protocol!
Our new Single Cell Methylation Kit is now available for pre-order.
Get a revolutionary view into cellular heterogeneity.
Pre-order now: scale.bio/scalebio-single-ce…
#singlecell #methylation #scalebio
Ruth V. Nichols & Brendan L. O'Connell retweeted
New preprint! sciMET-cap, where we use hybrid capture to reduce the sequencing burden of scMethylation and show ~6,000 cell preps are possible using a benchtop sequencer! Led by S. Acharya and @oconnellphds with @DrTedPBraun & @L_Rylaarsdam. biorxiv.org/content/10.1101/…
Ruth V. Nichols & Brendan L. O'Connell retweeted
Summary of our latest two papers on GenomeWeb! Thanks for the coverage - we are excited about both of these techniques regarding how they can improve the scale of single-cell epigenomic studies; both led by @oconnellphds! @OHSUSOM #singlecell #epigenetics
OHSU Researchers Push Throughput, Accessibility for Single-Cell Epigenetic Assays. An improved sample prep workflow for single-cell methylation analysis offers the prospect of commercialization, which could be readily taken up in cancer genomics. ow.ly/6NBa104wCnV
Ruth V. Nichols & Brendan L. O'Connell retweeted
Excited to have our work using the @TakaraBioUSA iCell8 instrument with single-cell combinatorial indexing to achieve high-throughput scATAC out in early access in @genomeresearch led by @oconnellphds! #singlecell @OHSUSOM @OHSUNews @OHSUBrain (1/4)
genome.cshlp.org/content/ear…
Ruth V. Nichols & Brendan L. O'Connell retweeted
A high-throughput method for generating single-cell DNA methylomes with high coverage @acadey80 @oconnellphds
go.nature.com/3WsKkGl
Super excited to have our paper out today! Went from the first experiment to an accepted paper in 1 year!
1/6 Very excited to announce sciMETv2 for high-throughput robust single-cell DNA methylation analysis led by @oconnellphds out in @NatureComms!
#SingleCell @OHSUBrain @OHSUKnight @OHSUNews @OHSUSOM #epigenetics
rdcu.be/c1kdp
New paper from our lab is out today! Brendan is a co-author. He worked on the s3-GCC portion
Our recent work on developing "s3" as a means of achieving increased unique read counts per cell for transposase based assays came out today! Led by Ryan Mulqueen along with an excellent team of collaborators.
nature.com/articles/s41587-0…
2
Ruth V. Nichols & Brendan L. O'Connell retweeted
Happy fifth birthday to Maple! Her team threw a party with branches, otters and Filbert, who took a cookie to go.
Ruth V. Nichols & Brendan L. O'Connell retweeted
Interested in single-cell genomics but need help keeping up with a rapidly changing field? Check out our free #singlecellgenomicsday workshop, starting in a few minutes! Full agenda and livestream at satijalab.org/scgd, or follow along below:
youtube.com/watch?v=lX4d12nT…
Ruth V. Nichols & Brendan L. O'Connell retweeted
Nice article discussing some of the complexities of variants found by @OregonCovidSeq team of scientists. @BenBimber @acadey80 @BenBimber @SallyGrindstaff @oconnellphds @snchry Kayla Carter.
So, we’ve all been hearing about the arrival of these COVID ✨variants✨
Is it time for us to go out and panic? @TheRealDrOLab says no. But it’s a bit complicated, and he very kindly explained the situation to me — check out the story @Oregonian ⬇️⬇️⬇️
oregonlive.com/coronavirus/2…
Ruth V. Nichols & Brendan L. O'Connell retweeted
@OregonCovidSeq has been busy the past ~month w/ 572 new genomes now in @GISAID. +5 complete #VOC #B117. As just reported by @apoorva_nyc, worryingly, one of these #B117 samples also contains the spike #E484K, which is a key mutation in #P1 & #B1351 #VOC 🧵1/10 on these & others
You’re unable to view this Post because this account owner limits who can view their Posts. Learn more
Over 2000 genomes sequenced!
>2,000 #SARSCoV2 genomes by @OregonCovidSeq team @BenBimber @acadey80 @PDXdengue @oconnellphds @SallyGrindstaff KaylaCarter @snchry and our partners at OHSU MM lab @drdonnahansel, Daniel Streblow, Alec Hirsch, Guang Fan, and @XuanXuanqin. OSPHL John Fontana & LaDonna Grenz. 8/10.