Startup builder. Business model nerd. Interested in mindfulness, marketplaces, crypto, investing, real estate.
Portland, ME
Joined April 2011
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Neil Spillane retweeted
NEW: China’s Z.AI begins operating a 1-gigawatt AI data center built entirely with domestic chips — enough power for roughly 750,000 homes.
Neil Spillane retweeted
Signal
LATEST: More than half of all $BTC in circulation is now held at an unrealized loss, a signal that has coincided with every major bear market bottom in history.
Neil Spillane retweeted
JUST IN: Autonomous AI agents are now trading on Polymarket in an attempt to subsidize their token costs.
“Polymarket: $10 experimental account”
Neil Spillane retweeted
Fantastic selection of Kevin Warsh for Fed Chair by @POTUS. Kevin is the right person at the right time. A perfect blend of market insight, economic skill and DC experience -- all combined with a confident embrace of change, so much so that he can explain Bitcoin and crypto better than almost anyone. Having a Fed Chair who understands the markets and also embraces crypto is good for the dollar and good for the country.
Neil Spillane retweeted
My eastbound red eye protocol (most flights US->Europe):
- eat before I leave home/office
- blue light blocking glasses the moment I enter airport (I look like a dork but DGAF)
- buy two of the largest water bottles available, there is never enough hydration on board
- vitamin c and tart cherry powder at same time
- melatonin and magnesium as soon as I’ve boarded
- as much omega-3 and vitamin e oil as I can stomach
- eye mask on, earplugs under noise cancelling headphones, aim to fall asleep as quickly as possible
- fly business if at all possible, seat back/flat as soon as possible after takeoff
- no booze or food on the flight
- sleep until absolutely necessary to wake
- coffee and high protein food after waking
- high dose methyl B6 and B12
- keep taking omega-3 and vitamin e every few hours
- same protocol next few days (vitamins B in the morning, melatonin and magnesium for sleep)
H/T @FountBio for turning me on to much of this. I can now warp between time zones with impunity. And this will be extra valuable when supersonic makes transiting time zones even faster.
Neil Spillane retweeted
Slowly, then all at once 🥉
Replit has become the tool of choice for every builder, from startups to large enterprises.
Thanks for your trust 🙏
Neil Spillane retweeted
What's incredible about AI is it regularly gets cheaper with new releases, even as that new version is more powerful. GPT-5 is substantially cheaper than GPT-4 across all flavors. It’s insane how amazing this era of software is going to be. From @simonw
Neil Spillane retweeted
When we lack real problems in our lives, our mind quickly sets out to imagine some.
Neil Spillane retweeted
A partner at a prominent law firm told me “AI is now doing work that used to be done by 1st to 3rd year associates. AI can generate a motion in an hour that might take an associate a week. And the work is better. Someone should tell the folks applying to law school right now.”
Neil Spillane retweeted
I was just scammed by a @Hyatt hotel — and what I’ve uncovered so far points to a *much* bigger issue.
A 🧵
(1/13)
Neil Spillane retweeted
I just realized something most people are going to lose when (as they inevitably will) they start using AIs to write everything for them. They'll lose the knowledge of how writing is constructed.
Neil Spillane retweeted
The Patriots Have the Consensus No. 1 Draft Class of 2025, but Their Next Folk Hero is UFDA Lan Larison buff.ly/NM3MqN8
Neil Spillane retweeted
Eliminating microplastics entirely is not realistic—they’re everywhere.
Reducing exposure, though? Totally within reach with some evidence-backed strategies. Think of it as imperfect avoidance.
My top tips are:
Try filtering tap water with a reverse osmosis system—studies show it catches 99.9% of microplastics and other chemicals.
Swap plastic bottles and aluminum cans (they have plastic linings too) for glass or stainless steel and skip disposable coffee cups—their plastic coatings leach over time—and grab a reusable mug instead. You should also cut back on canned goods. Research flags a potential 1,000% BPA spike in urine after consumption, so go fresh or BPA-free when possible.
Maybe the biggest tip? Avoid heating plastic: no microwaving in containers or stirring hot food with plastic utensils because heat accelerates chemical release. Upgrade your cookware too. Ditch degrading non-stick pans for stainless steel, cast iron, or ceramic, and pair them with wooden tools.
These tweaks hit the major exposure points.
You can’t escape microplastics—but you can fight back
Everyday habits like drinking from plastic bottles, eating canned soup, or microwaving popcorn can quietly expose you to harmful chemicals like BPA and PFAS
These toxins can linger in your body for years, increasing your cancer risk
The good news? A few strategic changes can dramatically cut your exposure:
• Use a reverse osmosis water filter
• Avoid drinking, as much as possible, out of plastic bottles and aluminum cans
• Avoid heating plastic (this includes drinking out of to-go coffee cups)
• Limit consumption of canned soup
• Think twice about eating microwave popcorn