Now: biology investing @ https://xitter.cf/t.co/Fmj3dMHPe7 Then: @Color | @SciFounders Biology is technology is biology

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Joined November 2010
How I know it's still early days for biology:
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I think this is the right move, good job to Pangram. I feel similarly about companies trying to build uncannily human-like virtual agents: I'd rather know that they're virtual and spend the resources making them helpful in other ways
Replying to @sqlanm
We can, but we won’t
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Heck yes. We are all so lucky
Intoxicating. I’ve been programming for 45 years, since so was 10. I’ve been a pro game coder for 33 years. Everything from hand coded assembly to UE 5.8. The paradigm shift to agentic coding is intoxicating. It is the biggest productivity jump I have ever experienced.
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Unless someone else wrote this tweet, this contradicts what Bryan said in person 8mo ago 🤷
I can't find a way to use my genome. I’m the most intense longevity athlete in the world and haven’t used my genome for a single thing. Fully sequenced in 2012. Again this year, paying $7,902 for matched 30x long read + 100x short read. Still, nothing. What am I missing?
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getting older feels like my model is getting worse but harness is getting better.
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have some lore to share: the first vibecoding company was not cursor or cognition or anthropic -- it was Season 6 of Silicon Valley > be me, techbro founder hired as a consultant to the show
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still true
and here I thought every week was tech week
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🧬🤔
Today's top movers on Supertake
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If you live, breathe & die cellular and biochemical assay dev, this is the role for you! It's an insanely great starting place for an early-career PhD (or equivalent) scientist interested in startups and working on some really cool programs/technologies. octant.bio/jobs?gh_jid=62147…
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We started cleaning our water and waterborne disease (e.g. cholera, typhoid) basically disappeared from the West. We can do the same thing for air.
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This guy is joking (I think), but I seriously think a 'bio bootcamp' program for people in tech wanting to work in bio could be great. I haven't touched a pipette in >10 years(!) but still draw on my early lab experience/intuition in my work today.
Replying to @MartinShkreli
I'm going to start a licensing program for bio dooming where we march applicants into a lab and force them to stitch together a 10kb construct from oligos with only a chatbot as a coach. To make it realistic we'll employ jaded postdocs as proctors to belittle them ruthlessly.
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Was recently talking to the CEO of a popular AI startup who had become curious about bio (which had organically become a good chunk of his customer base by revenue), and he asked me what books/resources could help him ramp up. I answered: "honestly, and you probably won't do this, but the most useful first thing would be real lab experience." He scoffed, but agreed.
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If you would like to help make this happen in some way, reach out. (Also, shout out to my own lab mentors, @seemaychou and @jrkelly; have learned so much from you guys!)
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Today we are announcing Prism, a Radial project to make protein motion measurable, predictable, and actionable. See more: prismscience.org Prism will be part of our life sciences division, Radial (led by @beckypferdehirt). The team (led by @stephanie_mul) will build a new foundation of data and AI models openly with the community. We @AsteraInstitute are excited to announce a $20M commitment to Prism’s effort: rebuilding the scientific pipeline around how proteins actually move and function
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Things that have increased risk much more than AI: 1. The naive belief that asymmetric weapons can be made in bio bc of AI 2. Slowing effective global monitoring and scientific sharing bc of geopolitics 3. Gutting CDC 4. Poor economics on ID drugs 5. Vaccine hesitancy
1. >10M people die of infectious diseases per year today. AI is already helping us get better at tackling that. 2. Many ways to create very dangerous bioweapons without any AI/synbio (and it was true for the last 50-75 years). The delta on risk is quite small imo.
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In two or three years there will be 10x the number of INDs and the same number of people you can recruit into a clinical trial. I don't understand what people think is going to happen. Everyone is funding molecular design but folks, we've got to also be funding new validation methodologies in a big big way.
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On behalf of the Intercept team, I’m excited to share that we’re launching our first “Request for Candidates”! We’re looking for the best science (and teams!) in the world that could plausibly meet our target product concept. Our ultimate goal is to radically reduce the burden of respiratory viruses, and an easy-to-use, safe, and effective preventative is a critical part of that puzzle. This request for candidates will be open until at least December 31st, but proposals received by October 12 will be prioritized. interceptfund.com/apply/broa…
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Bitter taste receptors lack introns? …why?
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woohoo @owl_posting! excited for this one
We bring you an absolute biotech banger this week. The good doctor @eryney_ok comes on the show with @owl_posting to tell us whether AI will fix biology and provide us with a new age of miracle cures . . . . or not. Also, some lighter topics like bioweapons doom and CHINA. corememory.com/p/ai-will-cur…
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