The Zhang lab studies (bio)chemical diversity of natural products and synthetic biology applications at Westlake University.
Hangzhou, CN
Joined March 2022
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We developed a prediction tool for the substrate amino acid of adenylation domains. Hope this can be helpful for NRPS analysis! nrpstransformer.cn
Lihan Zhang retweeted
NRPStransformer, an Accurate Adenylation Domain Specificity Prediction Algorithm for Genome Mining of Nonribosomal Peptides | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
And appreciate this beautiful News&Views by Dr. Grininger for our works.
nature.com/articles/s41589-0…
Excited to share plug-and-play engineering of PKSs in two back-to-back papers! We demonstrate two conserved sequences in a PKS module as robust cut sites for PKS reprogramming (rdcu.be/eigV2) and show bioalcohol production by engineered PKSs (rdcu.be/eigVB).
Also want to mention a recent great work by the Keasling lab about bioalcohol production by PKS! nature.com/articles/s41929-0…
Lihan Zhang retweeted
Breakthrough in Enzyme Engineering! Researchers from Westlake University published two back-to-back papers in Nature Chemical Biology, unveiling a novel approach to enzyme engineering that could revolutionize the way we manufacture complex chemical molecules.
👉nature.com/articles/s41589-0…
👉nature.com/articles/s41589-0…
#WestlakeUniversity #ResearchAtWestlake #Chemistry #Innovation #Enzyme @Nature
Lihan Zhang retweeted
Out today at @ScienceMagazine - giant PKZILLA proteins spew huge polyketide marine toxins, just like #Godzilla! Witnessed by @photocyte & @VikShende at @Scripps_Ocean science.org/doi/10.1126/scie…
Excited to share our work on stereochemical prediction of cis-AT modular PKS. We found the KR motif-based prediction is affected by the module architecture and taxonomic origin of the PKS, and provided an update in stereochemical prediction. beilstein-journals.org/bjoc/…
Lihan Zhang retweeted
We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio
nature.com/articles/s41589-0…
Lihan Zhang retweeted
Move over titin... introducing PKZILLA as the largest protein in life that makes one the largest nonpolymeric compounds in biology, the marine polyether toxin prymnesin. Congrats to @photocyte & @VikShende and rest of team! biorxiv.org/content/10.1101/…
Interesting PKS and C domain reaction!
Our recent work published on @NatureSynthesis
nature.com/articles/s44160-0…
Honored to have Prof. Ben Shen visit us at Westlake! NPDC is a truly wonderful resource and looking forward to exploring the strain collection. @lab_shen
Thank you Ben and the group for creating this >10k genomes (the number keeps increasing) and >100k strains database, whose strains are all available by request! npdc.rc.ufl.edu/home
Glad that our review has been selected as a VIP. Hope our bioinformatics-driven approach can be helpful in providing a clearer picture of T2PKS biosynthesis and the product molecules.
Type II Polyketide Synthases: A Bioinformatics-Driven Approach (Zhang and Xie) @npevolution onlinelibrary.wiley.com/doi/…
An updated catalogue of type II PKSs! (Charkoudian lab)
microbiologyresearch.org/con…
Lihan Zhang retweeted
Wishing you a wonderful spring for the new academic year!
#WestlakeSeasons #WestlakeYunguCampus
Lihan Zhang retweeted
See how Yajie Wang’s synthetic biology and protein engineering team at Westlake University’s WangSynbio Lab is exploring the use of engineered enzymes and modified microbes to create a healthier, cleaner and more sustainable world. #WomenInScience #WomensHistoryMonth #HerWestlake
Interesting terminal thiazole ring formation enzyme in PKS-NRPS!
pubs.acs.org/doi/10.1021/acs…
The terminal thiazole also seen in the recent Barbamide paper pubs.acs.org/doi/10.1021/jac…
