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Your beliefs about aging are killing you faster than any disease.
Most of us have been conditioned since childhood to accept that getting old means getting sick.
We've watched our parents decline, heard doctors dismiss symptoms as "just getting older," and absorbed countless messages that disease is unavoidable.
This mindset has inertia like a heavy rock—and it's shortening your life.
Here's how:
Self-Fulfilling Prophecy: When you believe decline is inevitable, you stop taking actions that prevent it. Why exercise if you're "going to fall apart anyway"?
Ignoring Early Warnings: You dismiss important health signals as "just getting older"—missing critical windows for intervention.
Learned Helplessness: You develop powerlessness about your health future, giving up entirely on preventative measures that could add decades of healthy living.
The shift that changes everything:
- Disease is NOT your destiny.
- The longer you live, the more tools we'll have to help you live even longer. Every day, scientists create new ways to help us stay healthy.
Your job isn't to find one perfect solution today—it's to stay healthy enough to benefit from tomorrow's breakthroughs.
The 4-Step Framework (that most people do backwards):
Change Your Mindset
Create Your Strategy (family history + genes)
Change Your Lifestyle
Use Helpful Tools
Most people jump straight to step 4 without steps 1-3. Then wonder why nothing works.
I did something similar with bio age tests in 2022, and have wanted to do this “poo test” version as well. I am completely unsurprised by this result
Same poop, seven labs, seven different answers. NIST proved it. About 30 companies will sequence your stool and mail you a verdict on your health, and the one thing that decides whether it's worth anything is the sequencing method, which they bury in the fine print.
Seven consumer gut tests, grouped by how deeply they actually read:
1. TINY HEALTH (@GetTinyHealth). Deep shotgun sequencing, which reads bacteria down to the exact strain, run in a certified clinical lab. It's built for babies and mums, where a gut is still assembling itself in the first year and the exact strain matters most. You get a report and a call with a specialist. $219, United States.
2. ZOE (@Join_ZOE). Shotgun too, and the only one here with a randomized trial of its own, called METHOD, built on PREDICT, a 34,000-person study that observed what people ate rather than dosing them. It's a coaching membership, so what you get is an app that scores foods, not your raw microbe list. Price is in flux during a site relaunch, historically around $100 a year. US, UK, Ireland, Netherlands.
3. JONA (@Jona_health). The widest net here, shotgun sequencing that reads bacteria, fungi, viruses and parasites, then an AI that summarizes the research for you. Good method, but that AI advice has never been clinically tested, and at $485 it's the priciest on the list. United States.
4. VIOME (@MyViome). The only one reading RNA instead of DNA, so it measures what your microbes are actively doing rather than just who's present. The catch is that it exists to sell you its own supplements based on the result, and the RNA method is still debated by scientists. About $199, ships internationally.
5. EVVY (@EvvyBio). Vaginal, not gut, shotgun sequenced and reviewed by a clinician who can route you to a prescription. It's the one test here with published accuracy numbers, 93% sensitivity against a clinical standard. $159, United States only.
6. BIOMESIGHT (@biomesight). Cheaper 16S sequencing, which reaches the genus, the family a bug belongs to, but can't name the exact species. What it does that almost none of the others will: it gives you your raw data to keep, and it ships worldwide. About $113, global.
7. OMBRE (@ombrelab). Also 16S, genus-level, and really a funnel to match you to its own probiotic subscription, so read the result knowing what it's built to sell. $229.99, United States.
Here's why the method matters. @NIST split one identical stool sample and sent it to seven consumer companies three times each. The number of microbes they reported ranged from 34 to 906, and of the 1,208 organisms named across the entire test, exactly three appeared in every sample.
Not one of these tests is cleared by the @US_FDA for diagnosis.
Signed and sponsored
BREAKING: More than 105,000 people have signed an online petition demanding Australian Prime Minister Anthony Albanese’s immediate resignation.
It only took 125,000 for them to introduce social media bans.
Sign & share change.org/p/call-for-resign…
Yes Elon, become one of us!
Replying to @PalmerLuckey
Widespread MRI usage done at least annually with AI reviewing the data would greatly improve wellbeing and mortality
Making the terror attack in Bondi about “the need for gun reform” is the single biggest deflection by Aussies leadership I have seen in the 15 years I have lived here - the govt should own up to the real issues!
Why Exercise Timing Doesn't Matter (For Deep Sleep)
Common advice: "Don't exercise within 3 hours of bed or you'll ruin your sleep."
I tested this for 90 days.
The result: Exercise timing had minimal impact on deep sleep duration.
Morning workout (6am): Average 108 minutes deep sleep
Afternoon workout (2pm): Average 110 minutes deep sleep
Early evening (6pm): Average 107 minutes deep sleep
Late evening (8pm): Average 98 minutes deep sleep
The pattern:
As long as I finished exercise 3+ hours before bed, deep sleep remained consistent.
The only significant drop: exercising within 2 hours of bedtime.
What mattered more than timing:
Intensity and volume.
Low intensity (easy run, light weights): 95 minutes deep sleep
Moderate intensity (tempo run, standard lifting): 110 minutes deep sleep High intensity (HIIT, heavy lifting): 105 minutes deep sleep
The sweet spot for me: moderate intensity.
Enough stress to trigger adaptation.
Not so much that recovery demands cut into deep sleep.
What this means practically:
Stop stressing about perfect exercise timing.
The "no exercise after 6pm" rule is unnecessarily restrictive.
Just finish 3+ hours before bed and you're fine.
What actually matters more:
Exercise consistency (4-5x per week beats sporadic intense sessions) Adequate intensity (moderate beats light for deep sleep) Total volume (2-4 hours per week minimum)
I wasted months trying to force morning workouts because I thought evening exercise would destroy my sleep.
The data showed that was nonsense.
As long as I wasn't exercising at 9pm right before bed, timing was irrelevant.
Test it yourself.
Track deep sleep across different exercise times.
I bet you'll find the same pattern.
Consistency matters.
Timing is mostly noise.
I ran a 90-day experiment tracking every variable that might impact deep sleep.
What I tested:
Exercise timing
Meal timing and composition
Supplement protocols
Temperature variations
Pre-bed routines
Various devices and interventions
What actually moved the needle:
Biggest impact (20+ minute increase):
- Room temperature below 65°F
- Vagus nerve stimulation before bed
- Sauna 1-2 hours before bed
Moderate impact (10-15 minute increase):
- Magnesium glycinate supplementation
- Carb-heavy dinner
- Consistent sleep schedule
- Minimal impact (<5 minute change):
White noise vs. silence
Specific breathing protocols
Most sleep supplements
What surprised me:
Exercise timing mattered less than I expected.
Morning, afternoon, or early evening exercise all produced similar deep sleep duration.
The only rule: not within 3 hours of bedtime.
What disappointed me:
Most sleep supplements did nothing measurable.
I tested 7 different formulations.
Only magnesium glycinate showed consistent improvement.
Everything else was placebo or minimal change within noise.
The winner:
Vagus nerve stimulation before bed added 20 minutes to my deep sleep.
Most consistent intervention I tested.
Worked regardless of other variables.
The lesson:
Most sleep optimization advice is noise.
A few interventions matter significantly.
Everything else is rounding errors.
Test systematically.
Measure objectively.
Keep what works.
Alzheimer's doesn't start when you get diagnosed.
It starts 20-30 years earlier.
Here's the timeline:
Age 40-50: Amyloid beta begins accumulating
Age 50-60: Tau tangles start forming
Age 60-70: Measurable cognitive decline begins
Age 70-80: Clinical diagnosis
By the time you notice symptoms, the damage has been accumulating for decades.
This is why I'm obsessed with deep sleep at age 36.
Not because I'm noticing cognitive problems.
Because the proteins that could cause problems in 2055 are accumulating right now.
The glymphatic system clears these proteins during deep sleep.
Every night with inadequate deep sleep = another night of incomplete waste removal.
Those proteins don't disappear.
They accumulate.
Over decades, they form plaques.
Those plaques drive neurodegeneration.
The intervention window is NOW.
Not when you start forgetting names. Not when you notice cognitive slowing. Now, while your brain is still efficiently clearing waste.
My strategy:
Optimize for 90+ minutes of deep sleep per night.
That's 547 hours per year of glymphatic clearance.
Over 20 years: 10,950 hours of brain waste removal.
Compare that to someone averaging 60 minutes of deep sleep:
365 hours per year. 7,300 hours over 20 years.
That's a 3,650-hour difference in brain maintenance.
The equivalent of 152 full days of additional waste clearance.
This isn't speculation.
It's basic math on a well-established biological process.
Start now.
Not when symptoms appear.
By then, you're managing decline instead of preventing it.
SUNDAY (GENERAL CONTENT #4)
Post 7: What Actually Increases Deep Sleep
Everyone has sleep advice.
Most of it doesn't move the needle on deep sleep specifically.
What the research actually supports:
✓ Moderate to intense exercise during the day (not within 3 hours of bed) ✓ Consistent sleep schedule within ±30 minutes ✓ Room temperature: 60-67°F (15.5-19.5°C) ✓ Carbohydrate-rich meal 2-3 hours before bed
These are non-negotiables.
Proven additions that increase deep sleep:
âś“ Magnesium glycinate supplementation (400mg before bed) âś“ Sauna exposure 1-2 hours before bed âś“ White or pink noise during sleep âś“ Vagus nerve stimulation before bed
Notice what's NOT on this list:
❌ Sleep supplements with 15 random ingredients
❌ Complicated breathing protocols requiring 30 minutes
❌ Expensive sleep trackers that just measure what you're already measuring
❌ Sleep gurus selling courses on "sleep optimization secrets"
My current protocol:
12:00pm: Last caffeine
5:30pm: Dinner with adequate carbs
7:15pm: Blue light blocking glasses on
7:45pm: Magnesium glycinate (800mg)
8:15pm: Soundbed (20 minutes)
9:00pm: Pulsetto sleep program (12 minutes)
9:30pm: Lights out, white noise on
Room temperature: 64°F
The result:
Average deep sleep: 110 minutes
Average sleep latency: 12 minutes
Average wake-ups: 0-1 per night
What I don't do:
Melatonin (makes me groggy)
Complex breathing protocols (too much mental effort)
Sleep restriction (counterproductive for total sleep)
Alcohol (destroys sleep architecture)
The foundation:
Get the basics right first.
Then add targeted interventions based on your data.
Most people do this backwards.
They buy supplements before fixing their sleep schedule.
They try complex protocols before making their room cool enough.
Build the foundation first.
Then optimize.
I just sent my subscribers the complete UV damage reversal breakdown—the most dramatic skincare results I've documented in years.
Here's what they're reading right now:
âś… Why photolyase enzymes can repair DNA damage that other interventions can't touch
âś… The complete 8-week protocol combining LADR serum with red light therapy
âś… Before/after Visia scan data showing 20% UV damage improvement during spring
âś… The dramatic inflammation reduction visible in the scans (most striking visual change in years)
✅ 21% forehead wrinkle improvement—the second horizontal line nearly disappeared
âś… What didn't change (brown spots, pores, texture) and why that validates the results. Most skincare products stabilize damage or slow progression.
This protocol actually reversed accumulated UV damage. Measured with professional equipment. Documented over 8 weeks.
**If you want the deep dives on longevity interventions tested with professional measurement—join here:**
Link below👇
Amyloid beta and tau proteins.
If those sound familiar, it's because they're the hallmark proteins found in Alzheimer's disease.
Here's what most people don't know:
These proteins accumulate in everyone's brain throughout the day.
They're normal metabolic waste products.
The difference between healthy aging and neurodegeneration?
How efficiently your brain clears them out at night.
Your brain's glymphatic system handles this clearance.
But it primarily operates during deep sleep.
Not light sleep. Not REM sleep. Deep sleep specifically.
This is why sleep duration alone doesn't tell the whole story:
8 hours of fragmented, light sleep with minimal deep sleep = poor waste clearance
6.5 hours with adequate deep sleep cycles = better waste clearance
My current focus:
I'm less concerned about total sleep time than I am about deep sleep duration.
Target: 90+ minutes of deep sleep per night
Current average: 110 minutes
That's 140 extra minutes per week of glymphatic clearance compared to my baseline.
This compounds.
Not tomorrow. Not next month.
In 2045 when I'm comparing cognitive function to peers who spent decades with inadequate deep sleep.
Track your deep sleep.
Not just your sleep score.
Most people quit interventions too early.
Or continue them too long.
I follow a simple framework:
Week 1-2: Adaptation phase (ignore results) Week 3-4: Initial data collection Week 5-8: Pattern confirmation Week 9-12: Decision point
Week 1-2: Adaptation
Your body is adjusting. Your measurement baseline is shifting. Your placebo effect is strongest.
Don't make conclusions here.
Just document.
Week 3-4: Initial Data
Placebo effect is declining. Actual patterns start emerging. You have enough data for preliminary trends.
Look for consistent changes:
Sleep metrics moving in same direction
Subjective experience aligning with data
Changes persisting through variable conditions
Week 5-8: Pattern Confirmation
The intervention is either working or it isn't.
If working: patterns are obvious and consistent If not working: you're searching for explanations
Week 9-12: Decision Point
Keep it (clear measurable benefit) Modify it (partial benefit, needs optimization) Stop it (no benefit, wasting time/money)
Most people fail at decision time:
They keep ineffective interventions because of sunk cost.
"I've already invested 3 months..." "Maybe I just need to give it more time..." "Perhaps I'm not doing it right..."
If it's not working by week 12, it's not working.
My current protocols all passed this test:
Pulsetto: Clear sleep latency improvement by week 2, sustained through week 12+ Blue light glasses: Immediate subjective response, measurable by week 4 Chanca Piedra: Blood pressure dropped 20 points by week 4
What failed:
NMN: No NAD+ change by week 12 Cold plunge: Initial excitement, no sustained benefit by week 8 Multiple supplements: No biomarker changes, discontinued
The framework protects you from two mistakes:
Quitting effective interventions too early (before adaptation completes) Continuing ineffective interventions too long (after data shows no benefit)
Test for 12 weeks.
Measure objectively.
Decide based on data, not hope
Most people optimize backwards.
They take supplements for brain health.
They try nootropics for cognitive performance.
They track biomarkers obsessively.Meanwhile, they're getting 6 hours of fragmented sleep.
Here's what they're missing:
Your brain has a waste removal system called the glymphatic system.
It clears out the exact proteins (amyloid beta and tau) that pile up in Alzheimer's disease.
But it only operates during deep sleep.
A 2020 review established three facts:
Glymphatic clearance plays a major role in Alzheimer's pathology
The vast majority of waste clearance happens during sleep
Dementias are strongly associated with sleep disruption
Translation: Poor sleep = inadequate brain waste removal = accumulating the proteins that drive cognitive decline.
My personal data:
I've been tracking this for months with my Oura ring.
Baseline deep sleep: ~90 minutes per night
With targeted intervention: ~110 minutes per night's 20 extra minutes of glymphatic clearance.
Every single night.
Over a year: 121 hours of additional brain waste removal.
Over a decade: 1,217 hours.
The intervention?
Vagus nerve stimulation before bed using the Pulsetto device.
I didn't expect it to impact deep sleep duration this significantly.
But the data doesn't lie.
Full breakdown in today's newsletter—including:
âś“ Why sleep come before every other longevity intervention
âś“ What actually increases deep sleep (research-backed, not sleep guru nonsense)
âś“ The connection between inadequate deep sleep and neurodegenerative disease
âś“ My exact protocol and tracking This isn't about feeling more rested tomorrow.
It's about preventing neurodegeneration in the years to come.
Link below!
Someone always asks:
"But where are the clinical trials?" "Show me the peer-reviewed research!" "I need randomized controlled studies!"
I get it. I used to think the same way.
Then I noticed something:
Clinical trials tell you what works for average populations.
They don't tell you what works for YOUR biology.
Example: NMN supplementation
Published studies show NAD+ increases. Podcasts rave about the benefits. Longevity experts recommend it.
I took 2g daily for 90 days.
Tested my NAD+ levels before and after.
Result: No change.
Zero. Nothing.
The study results were accurate.
For the average participant in that study.
Not for my specific metabolism.
This is why I run personal experiments:
Your genetics affect supplement absorption. Your gut microbiome changes bioavailability. Your existing nutrient status alters response. Your stress levels modify effectiveness.
A clinical trial can't account for YOUR variables.
My framework:
Research suggests mechanism is plausible
Safety profile is acceptable
I can measure the relevant biomarker
Test for 8-12 weeks with before/after data
Remove and verify benefits disappear
Decide based on MY results, not study results
This doesn't mean clinical research is useless.
It means clinical research tells you where to START testing.
Not where to STOP thinking.
The Pulsetto doesn't have published RCTs.
But I have:
Baseline sleep data without it
Intervention data with it
Removal data without it again
Restoration data with it again
That's more useful than knowing it worked for 50 people in a study I wasn't part of.
Test on yourself.
Measure objectively.
Decide based on your data.
Not on population averages.
6:15am: Alarm goes off.
First conscious thought: Immediate anxiety.
Not about anything specific. Just a general 7/10 activation that colors everything.
This was my baseline for years.
What I tried:
Meditation: Helped, but took 20-30 minutes Breathing exercises: Helpful, but required active focus Cold showers: Temporarily activating, not regulating Supplements: No measurable change Therapy: Addressed causes, but didn't change the morning spike
The pattern:
By the time I got the anxiety down to functional levels (4/10), I'd spent 30-45 minutes of my morning just managing my nervous system.
That's 210-315 minutes per week. That's 182-273 hours per year.
Just trying to feel baseline normal.
What changed with vagus nerve stimulation:
6:15am: Wake up, still 6-7/10 anxiety (this hasn't changed)
6:20am: Pulsetto anxiety program for 6 minutes
6:26am: Down to 3/10
The anxiety upon waking hasn't disappeared.
But the time to regulate dropped from 30 minutes to 6 minutes.
That's 24 minutes recovered every morning.
168 minutes per week. 146 hours per year.
Here's what matters:
Those 146 hours aren't just "saved time."
They're starting my day from a regulated state instead of a dysregulated state.
Every decision I make that day starts from 3/10 instead of 7/10.
That compounds.
Morning meetings: more present, less reactive.
Creative work: better focus, less scattered Interactions: more patient, less irritable
The intervention that matters isn't the one that makes anxiety disappear.
It's the one that helps you regulate faster.
Because regulation determines everything else.
I test a lot of longevity tech.
Most of it gets used for 30-90 days, then forgotten.
The devices that stay in my routine pass three tests:
Measurable benefit within 4-8 weeks
Noticeable decline when removed
Worth the time/money investment long-term
Current daily stack:
Morning:
Bon Charge blue light glasses (worn all day)
Pulsetto anxiety program (6 minutes)
Evening:
Bon Charge Onyx glasses (2 hours before bed)
Pulsetto sleep program (12 minutes before bed)
Weekly:
Red light panel (15 minutes, 3x per week)
That's it.
What I don't use daily anymore:
Cold plunge (benefits didn't justify time investment)
Continuous glucose monitor (taught me my patterns, don't need constant monitoring)
NMN supplementation (tested NAD+ levels, no change)
Countless other devices gathering dust
The pattern I've noticed:
Effective tools become invisible.
You stop thinking about them. They're just part of your routine. You only notice when they're gone.
Ineffective tools require constant attention.
You're always trying to optimize the protocol. Always wondering if you're doing it right. Always justifying the investment.
If you're constantly thinking about whether something works, it probably doesn't.
The Pulsetto passed all three tests:
Measurable: Sleep latency dropped by 45% within 2 weeks Removable: All benefits disappeared within 3 days of stopping Sustainable: 18 minutes daily (6 morning, 12 evening) is manageable indefinitely
That's why it's still in my routine 6+ months later.
The worst part of poor sleep isn't falling asleep.
It's waking up at 3am and lying there for 45 minutes.
Your mind starts racing:
Tomorrow's deadlines
Conversations you need to have
Problems you can't solve at 3am anyway
Meanwhile, you're watching the clock.
3:15am. Still awake. 3:30am. Still awake. 3:47 am. Finally drifting off. 5:45am. Alarm goes off.
This was my pattern without intervention:
Wake up 2-3 times per night.
Take 20-30 minutes to return to sleep each time.
Total: 40-90 minutes of interrupted sleep.
With the Pulsetto:
Wake up 0-1 times per night. Return to sleep within 5 minutes.
Total: <10 minutes of interruption.
The difference in total sleep time? About 15 minutes.
The difference in how I feel the next day? Massive.
Because sleep fragmentation matters more than total sleep.
7 hours of uninterrupted sleep beats 8 hours with 5 wake-ups.
Your glymphatic system (brain waste removal) only works during uninterrupted deep sleep.
Every wake-up shuts it down.
That's 20-30 minutes of interrupted beta-amyloid clearance.
Multiply that by 2-3 wake-ups per night.
Then by 365 nights per year. Then by 30 years.
That's not just poor sleep quality.
That's accelerated brain aging.
This is why I track sleep fragmentation more obsessively than sleep duration.
Not for tomorrow's energy.
For my cognitive function in 2055.
Everyone tracks:
Total sleep time
Sleep score
REM percentage
Deep sleep duration
They miss the metric that predicts how you'll feel tomorrow:
Sleep latency.
Not how long you sleep. How long does it take to fall asleep?
Here's why this matters more than people realize:
Sleep latency reveals your nervous system state.
10 minutes or less: Parasympathetic dominant, relaxed, ready for sleep 15-20 minutes: Borderline, some lingering activation 25+ minutes: Sympathetic dominant, stressed, not ready for sleep
Your REM and deep sleep percentages matter.
But if you're spending 45 minutes trying to fall asleep, you're losing that time from your recovery window.
My data over 6 months:
With Pulsetto: Average 12-minute sleep latency Without Pulsetto: Average 22-minute sleep latency
That's 10 minutes difference.
Over a year: 60 hours of extra sleep time. Over a decade: 600 hours.
But the real impact isn't the time.
It's what those 10 minutes represent:
Faster parasympathetic activation, Lower cortisol before bed, Better sleep architecture throughout the night more efficient recovery
When you fall asleep in 10 minutes, your nervous system is ready.
When it takes 30 minutes, you're forcing sleep while still activated.
Track your sleep latency.
If it's consistently above 20 minutes, something needs to change:
Evening light exposure
Stress management
Caffeine timing
Pre-bed routine
Room temperature
Or tools that directly activate your parasympathetic system.
Your Oura/Whoop/Garmin shows you this number.
Most people ignore it.
I track it more closely than total sleep time.













