MS/Neuroimmunology Neurologist & Assistant Professor @UAlberta_FoMD | Alum: @MayoClinicNeuro, @UAlberta_FoMD, @UCalgaryMed, @HotchkissBrain | Views=my own
Edmonton, Alberta
Joined December 2010
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Nabeela Nathoo, MD, PhD, FRCPC retweeted
Spinal cord involvement in histiocytic neoplasms is underrecognized, and it's often how the disease first shows up.
With effective MAPK-targeted therapies (BRAF/MEK) available, early diagnosis matters.
In @GreenJournal, we studied 415 patients with ECD, LCH and RDD from the @MayoClinic cohort:
🔹 10% had spinal cord or nerve root involvement
🔹 In 1 of every 2 symptomatic patients, it was the FIRST sign of the disease
🔹 ECD → mainly cord infiltration; RDD → mainly nerve roots or extrinsic compression
🔹 Improvement after treatment: RDD 91%, LCH 67%, ECD only 46%
👉 Think spinal MRI early in patients with neurologic symptoms or high-risk features.
🔗 neurology.org/doi/10.1212/WN…
#NeuroTwitter @Histiocytosis @HistiocyteSoc
Our new review explores cellular senescence in #MultipleSclerosis: linking aging biology, immune changes, viral contributions & brain atrophy, and examining senotherapeutics as potential approaches to progressive MS.
frontiersin.org/journals/imm…
Thrilled to share our review on safety of complement inhibitors (eculizumab, ravulizumab) during pregnancy in NMOSD & MG-->early case data + larger PNH/aHUS cohorts show no consistent harm signal, but more studies specifically in NMOSD and MG are needed rdcu.be/3JLEUmTqXXta
Nabeela Nathoo, MD, PhD, FRCPC retweeted
Delighted to share our international review on MRI Characteristics of #MOGAD! ➡️ Key imaging features are highlighted across the brain, optic nerves & spinal cord including lesion dynamics ➡️ Illustrative figures help show its full imaging spectrum👇
jamanetwork.com/journals/jam…
Nabeela Nathoo, MD, PhD, FRCPC retweeted
Ethnicity does not strongly correlate with multiple sclerosis severity. Senior author @drruthdobson onlinelibrary.wiley.com/doi/…
Nabeela Nathoo, MD, PhD, FRCPC retweeted
3.1 million people are now living with MS worldwide. Published today, this new estimate draws on data from 133 countries, representing 93% of the world's population. It provides the most comprehensive picture of global MS prevalence and incidence to date. msintfederation.org/4cMl0FV
Nabeela Nathoo, MD, PhD, FRCPC retweeted
Enterovirus infection in B-cell depleted patients may cause severe central nervous system involvement, and early IVIg and investigational antivirals may be considered.
Narrative review with two illustrative cases from @AKunchok @ClevelandClinic ▶️ journals.sagepub.com/doi/10.…
Nabeela Nathoo, MD, PhD, FRCPC retweeted
We're proud to introduce the inaugural Michelle Ploughman Award, as part of this year's Annual Research Competition, recognizing and supporting the next generation of #MS rehabilitation researchers.
Apply for an endMS Personnel Award.
Learn more: bit.ly/4qmenzC
Check out our recent work!
A significant number of people with progressive MS have symptoms associated with a single prominent lesion in a critical area, often in the spinal cord. In secondary progressive MS, a prior relapse often caused symptoms similar to the current progression pubmed.ncbi.nlm.nih.gov/4244…
Nabeela Nathoo, MD, PhD, FRCPC retweeted
Thank you, @GreenJournal, for inviting me to discuss our paper! As a bonus, we also talked about how to diagnose amyloid neuropathy. This is one of my favorite neuropathy topics, so I spoke a lot. 😅 I hope you will enjoy it! open.spotify.com/episode/6oI…
Nabeela Nathoo, MD, PhD, FRCPC retweeted
Clinical Manifestations, Tumor Associations, and Long-Term Outcomes of Anti-KLHL11 Encephalitis: hubs.la/Q04kbZpG0
Nabeela Nathoo, MD, PhD, FRCPC retweeted
A 37-year-old woman with #MultipleSclerosis treated with ofatumumab developed enteroviral encephalitis (with fever, confusion, seizures, altered consciousness, and residual neuropsychiatric symptoms).
Case report from @UofT @StMichaelsFdn ▶️ journals.sagepub.com/doi/ful…
1/🧵
An honour to get to be part of such a momentous occasion, at the first African MS conference (@Africtrims) in Ghana, though sadly virtually for me!
An excellent episode reframing how we view and approach palliative care in #multiplesclerosis by 2 powerhouse neurologists out of @UAlberta_DoM
Listen to Drs. Penelope Smyth and Janis M. Miyasaki discuss their article on “Palliative Care in Multiple Sclerosis" in the April #MultipleSclerosis and Related Disorders issue. Episode out on all podcast platforms or at hubs.la/Q04hb8H10
Nabeela Nathoo, MD, PhD, FRCPC retweeted
A case report of Enteroviral encephalitis in a 37 year old woman taking kesimpta for multiple sclerosis. IgG was normal and IgM was low. MRI brain (image) shows symmetrical lesions in the thalamus. She improved but with ongoing neuropsychiatric symptoms journals.sagepub.com/doi/10.…
Nabeela Nathoo, MD, PhD, FRCPC retweeted
7 Tesla MRI of the spinal cord in multiple sclerosis reveals lesions which were invisible on 3 Tesla MRI. pubmed.ncbi.nlm.nih.gov/4203…
Nabeela Nathoo, MD, PhD, FRCPC retweeted
Key Point 4 from the article Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease by Eoin P. Flanagan and Cheryl Hemingway from the April #MultipleSclerosis and Related Disorders issue, which is available to subscribers at hubs.la/Q04ccmZs0. #NeuroTwitter #MedEd
Nabeela Nathoo, MD, PhD, FRCPC retweeted
The authors of a new Review Article propose a modification of previous algorithms to identify patients with spinal epidural abscess in whom an urgent MRI is warranted (seen in figure). Learn more about the diagnosis and treatment of spinal epidural abscess: nejm.org/doi/full/10.1056/NE…
ALT A diagram showing an algorithm for use of urgent MRI to evaluate for spinal epidural abscess.
Nabeela Nathoo, MD, PhD, FRCPC retweeted
Happy to share @andreuvilaseca7 et al collaboration with @ESotirchos on the TRUE-MOGAD Score to discriminate true & false positive MOG-IgG
➡️ We have created an online calculator for ease of use:
news.mayocliniclabs.com/true…
The article link is below:
👇 neurology.org/doi/10.1212/NX…
Nabeela Nathoo, MD, PhD, FRCPC retweeted
Rescue cyclophosphamide treatment was used in 23 people with #MultipleSclerosis from 2009 to 2024, and was associated with improvement in relapse-associated disability.
🔓MSJ-ETC study from @UBC ▶️ journals.sagepub.com/doi/ful…
