Dana-Farber Cancer Institute @DanaFarber, Harvard Medical School @harvardmed, @MSKCancerCenter, Weill Cornell @WeillCornell, Johns Hopkins @hopkinskimmel
Boston
Joined April 2008
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Kornelia Polyak retweeted
Since launching @LabPolyak in 1998, Kornelia Polyak, MD, PhD, has focused on a fundamental question: how does breast cancer form? New research suggests that shifts in immune activity may be one of the earliest steps. Learn more: bit.ly/4sXDUP3
Kornelia Polyak retweeted
Happy to share our new manuscript: Whole-genome doubling drives immune evasion by silencing antigen presentation: Cancer Cell cell.com/cancer-cell/fulltex… @LabPolyak @DFCI_BreastOnc @oesterreichs @Adrianvlee @ZheqiL
Happy to share our new manuscript: Whole-genome doubling drives immune evasion by silencing antigen presentation: Cancer Cell cell.com/cancer-cell/fulltex… @LabPolyak @DFCI_BreastOnc @oesterreichs @Adrianvlee @ZheqiL
Kornelia Polyak retweeted
New @Cancer_Cell paper from @LabPolyak: Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression
👉pubmed.ncbi.nlm.nih.gov/4199…
@ZheqiLiu @yan_pengze @umd_emd @QinYan1
@Adrianvlee @DrShelleyHwang @simocristea @nellage
Kornelia Polyak retweeted
New study from @LabPolyak now out in @CD_AACR: HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies
pubmed.ncbi.nlm.nih.gov/4192…
@yan_pengze @ZheqiLiu @sflomos @nellage
Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression: Cancer Cell cell.com/cancer-cell/fulltex…
HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies aacrjournals.org/cancerdisco…
HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies aacrjournals.org/cancerdisco… @LabPolyak @DFCI_BreastOnc
Kornelia Polyak retweeted
New study from the @LabPolyak on aging-associated differences in mammary tumor-initiating populations and immune evasion pathways in #BreastCancer
🔓pubmed.ncbi.nlm.nih.gov/4171…
@yan_pengze @nellage @PNASNews
Do not ship precious perishable samples with #FEDEx especially not international. Even if they have all paperwork they don’t deliver in time - they do not care.
Kornelia Polyak retweeted
Dr. Kornelia Polyak (@nellage) discussed the molecular and immunological basis of #BreastCancer across the age continuum in the #SABCS25 session on breast cancer in young women. @LabPolyak
Kornelia Polyak retweeted
Our study on histone tail cleavage is out today in @NatureGenet . We found KDM4C prevents CTSL-mediated histone H3 tail clipping by modulating its recruiter GRHL2, reducing oxidative stress and promoting basal tumor growth. Congrats to @ZheqiL @nellage
nature.com/articles/s41588-0…
happy to share our manuscript that just came out in Nature Genetics, it took us more than 10 years to solve this puzzle.
nature.com/articles/s41588-0…
This will harm cancer centers, where most cancer research is done. They don’t have endowment. Why would anyone want to destroy hospitals that work on saving lives???
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above what many major foundations allow and much lower than the 60%+ that some institutions charge the government today. This change will save more than $4B a year effective immediately.
Sadly I will miss the first Halloween MCO party, but at least our lab is represented.
🎃Polyak lab is getting ready for the MCO halloween pumpkin decoration contest! Huge shoutout to @MarieAnneGoyet1 and Andriana who made this piece of work based on the lab logo! Science and creativity go hand in hand!
and our first aging paper is out! @LabPolyak @DFCI_BreastOnc
Midkine as a driver of age-related changes and increase in mammary tumorigenesis: Cancer Cell cell.com/cancer-cell/fulltex…
Our paper showing that stromal interactions induce sugar coating and make cancer cell resistant to treatment:
Cancer–stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies | PNAS pnas.org/doi/abs/10.1073/pna…