@ncdhani

Chemo doctor, hypoxia scientist and mom. Realistic optimist striving for that elusive work-life balance and making cancer a chronic disease.

Toronto
Joined April 2014
🧵 1/10 The arc: POLAR - MDF – TIE Pancreatic cancer is profoundly resistant to immune checkpoint inhibitors. Yet, POLAR (pembrolizumab plus olaparib) trial showed that a subset of patients, especially with HRD (gBRCA2/1m or gPALB2m) tumors, can achieve remarkably durable control. That led us to two questions: #1 👆🏼what makes these tumors immunogenic? #2 ✌️what makes that immunity actually work? 👑 #2. POLAR TIE @biorxivpreprint biorxiv.org/content/10.64898… #1. MDF biorxiv.org/content/10.64898… #0. POLAR @NatureMedicine nature.com/articles/s41591-0… #cancer #immunotherapy #PancreaticCancer #ICI #BRCA #HRD #3episodes @MSKCancerCenter @MSK_DeptOfMed @CpcrMsk @ldiaz1971 @debschrag @PanCAN @oncodaily @OncoDailyGI @OncoAlert @OncBrothers @brunolarvol – at Manhattan, NY
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🚨 The @FDA has granted “Breakthrough Therapy” designation to FMISO, a specialized imaging tracer that can help identify patients with #HPV-positive #throatcancer who may safely receive less-intensive radiation treatment. “This has been an absolute game changer for treating certain people with throat cancers caused by the human papillomavirus or HPV,” says MSK radiation oncologist @imrtlee, who pioneered the approach. Learn more: bit.ly/4AbDBoW
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Neesha Dhani retweeted
Four areas of opportunity highlighted in @theNCI FY2028 Annual Plan: -Advancing Functional Precision Medicine -Expanding the Reach of Cell-based Immunotherapies -Fully Utilizing Pediatric Cancer Data -Leveraging Tumor Atlases to Predict Cancer’s Evolution cancer.gov/research/leading-…
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Neesha Dhani retweeted
Had a lot of fun @I95Metro showcase! Went 2 for 2 at the plate, 2 stolen bases and made a couple of good plays at SS and 2B. Thank you to all of the coaches in attendance for this amazing opportunity! #685 @TorontoMets @CPBLeague @OBC_Recruits @CDNBaseballNet @BlueJaysAcademy
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Top Outfield, Infield, and Firstbase Velocities from the 2026 PG WWBA Workout Showcase (July 5th) in Marietta, GA. Check out the full Workout Results here: perfectgame.org/Events/Defau… @PGShowcases @PerfectGameUSA
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Top 10 Yard Splits and 60 Yard Dash Times from the 2026 PG WWBA Workout Showcase (July 5th) in Marietta, GA. Check out the full Workout Results here: perfectgame.org/Events/Defau… @PGShowcases @PerfectGameUSA
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Nice hit @RoShowBaseball!!! was great to spend #Canada day watching you represent 🍁 @PrepBaseballNY #NYSgames lots more baseball to come!
SS/RHP Rohan Persad 2027, @TorontoMets @PB_Uncommitted Persad drills this one into the LCF gap for a triple. The two-way out of the Met’s system collects his second hit this game. #NYSGames || @RoShowBaseball
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SS/RHP Rohan Persad 2027, @TorontoMets @PB_Uncommitted Persad laces this one thru the right-side for a backside single. Two-way out of the Mets’ system w/ a fastball the reaches the mid-80s. #NYSGames || @RoShowBaseball
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Good job @RoShowBaseball! Nice work at the plate and on the mound (& double-play!) keep being that triple-threat ballplayer ⚾️💪🏽 #BetterEveryDay
Highlights from the #MPL26 tournament in Indiana @Bullpenevents @prepbaseball @PrepBaseINScout @PrepbaseballON Clip 1: Base hit to center field. Clips 2 & 3: 2 Ks as the Closer to secure the Mercy for @TorontoMets @CPBLeague @richleitch47 @RDM_26 @DuncanWatt19 @ding3722
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Happy Father’s Day to all the dads spending “their” day driving to baseball diamonds & the like. we see you and appreciate everything you do everyday for the ones who made you the dads you are. Missing the dads and grand-pas who left us way too early 💔
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Neesha Dhani retweeted
It was a fun experience at the @PGShowcases #JrNational Showcase in Georgia! Hit a stand up oppo double during game play. Thank you @pg_int1 @PerfectGameUSA PGTV @JeredGoodwin3 @PG_Uncommitted @TorontoMets @CPBLeague @richleitch47 @OBC_Recruits @CDNBaseballNet @BlueJaysAcademy
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Great job this weekend @RoShowBaseball keep working hard 💪 we’re very proud of how far you’ve come & looking forward to more great baseball ⚾️ @TorontoMets
High speed BP swing from '28 SS Rohan persad (ON CAN)... #BeastoftheEast @pg_int1
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Neesha Dhani retweeted
‘28 Rohan Persad (ON-CAN) @pg_int1 #JrNational
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Neesha Dhani retweeted
"Grateful, but I don't like any of it." I asked Bassitt about the standing ovation he got from the Blue Jays' crowd yesterday. Covering Cbass for his years in Toronto, I know he doesn't like a fuss made about him, but if you don't, Bassit hates getting attention: @6ixinningpod
Forever OUR Hound on the Mound 🐶 Welcome back, @C_Bass419!
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Neesha Dhani retweeted
#ASCO26 This one is special. This is the hottest paper of 2026 and potentially in the history of pancreatic cancer. Let’s dive in. RASolute 302: Daraxonrasib vs investigator’s choice chemotherapy in previously treated metastatic pancreatic cancer Abstract LBA5 (soon!) Presentation: May 31, 2026, 3:21-3:33 PM CDT For decades, pancreatic cancer has been where good ideas go to die. We have optimized chemotherapy. We have sequenced chemotherapy. We have celebrated modest gains. But the central driver of PDAC has always been sitting there in plain sight: RAS. More than 90% of pancreatic cancers have oncogenic RAS mutations, and until recently, we had essentially nothing direct to do about it. Daraxonrasib is an oral RAS(ON) multiselective inhibitor targeting the active GTP-bound state of mutant and wild-type RAS. And in RASolute 302, it delivered. Quick hits: 📌 Phase 3 international randomized trial 500 patients with previously treated mPDAC Daraxonrasib vs investigator’s choice chemotherapy 🧬 RAS G12 population 91.8% of patients had RAS G12 mutations 📈 OS in RAS G12 population 13.2 vs 6.6 months HR 0.40 P<0.001 📈 OS in overall population 13.2 vs 6.7 months HR 0.40 P<0.001 📊 PFS in RAS G12 population 7.3 vs 3.5 months HR 0.45 P<0.001 📊 PFS in overall population 7.2 vs 3.6 months HR 0.49 P<0.001 🔥 12-month OS Overall population: 53.2% vs 17.3% ⚠️ Toxicity matters, but this was not just more efficacy for more toxicity Grade ≥3 AEs: 61.8% vs 69.6% TRAEs leading to discontinuation: 1.2% vs 11.2% This is the kind of survival curve we almost never get to see in pancreatic cancer. This validates RAS(ON) inhibition in the most RAS-addicted major cancer. It takes a target we have talked about for decades and turns it into a clinically meaningful survival benefit in a randomized phase 3 trial. The next questions come fast: 1L combinations, maintenance, perioperative disease, sequencing, resistance, toxicity management, and whether this becomes a new backbone. RAS is here, and it couldn’t have come sooner. nejm.org/doi/full/10.1056/NE… @TheGutonclab @UGrewalMD @TimothyJBrownMD @OncoAlert @Onco_Nexus @ASCO @NazliDizman @LauraAlderMD @DVAraujoMD @DrBarbiOnc @LauraEsfeller @FunchainMD @YGaritaonaindia @DrSAHaddad @jgong15 @iandresmeraz @SakditadMD @RamilaShilpakar @RohitBanwar @lungoncdoc
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1/ the @NHS-Galleri trial is 1st RCT for molecular screening for early cancer detection. 142K participants; found ~1400 cancers overall (i.e. 1% ). No sig reduction in incidence rates of stage III/IV cancers. No change in rate @ prevalent vs incident rds.
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Neesha Dhani retweeted
Carter Hart is about to play in the Stanley Cup Final. He was acquitted of sexual assault charges this past summer, but there is a lot more to the story. With the brightest lights now shining on him, it is important to understand the nuance of the controversial case. “We Believe E.M” does not mean we believe every detail of her testimony. It does not mean we believe she did not make any mistakes that night. It simply means we believe she was sexually assaulted. And the evidence supports that belief. I will leave you with some facts. This is all available if you research (tw // sa): - There is ZERO evidence or testimony that EM ever asked Michael McLeod to invite additional men to that hotel room. McLeod never testified, and all we have is a video interview with police where he never made that claim, meanwhile LYING when he denied sending a text invite to ALL his teammates. On the otherhand, there is text evidence the following day of EM telling McLeod she did not expect more partners, and it was not disputed by McLeod. - There is ZERO evidence or testimony that EM ever asked (or was asked) for Cal Foote to do the splits over her. Even if you believe the men’s story that she was saying “have sex with me”, she never said “teabag me”. The judge actually agreed in her report there was no consent, instead she dismissed it saying it was non-sexual based on Carter Hart’s testimony that Foote was not naked. - In 2022, Alex Formenton & Dillon Dube BOTH CONFESSED to Hockey Canada that Cal Foote was naked during the splits. This was ruled inadmissible on a technicality. Other than Hart, no other witness dared to say Foote was clothed; they all pretended to not remember. With this information, at the very least, McLeod and Foote are guilty: - Foote performed a sexual act without consent. It does not make him a rapist, but it is a crime - McLeod is an accessory to that sexual assault If these two men were given the guilty verdict I strongly believe they deserved (even if it was a proverbial slap on the wrist; i.e. a 6-month house arrest), it would have been an amazing teaching moment for our nation while setting a modern standard for consent. The conduct of the others, including Hart, may not have been illegal. There was certainly not enough evidence to prove it was. But that does not mean what they did wasn’t morally reprehensible. The NHL and Hockey Canada both agreed. The NHL kept the players out of the league for months PAST the ruling, citing their own private investigation. Hockey Canada stood in the House of Commons and said “harm was caused” after paying out a civil settlement. But what Hart did was more than morally wrong. He lied under oath to protect his teammates. This is actually perjury. The judge by law is not privy to those 2022 confessions, but we as a public are. We are allowed to pass judgement in the court of public opinion. Hart is not a conquering hero who overcame adversity. He is a liar who abused his privilege and legal protection to obstruct justice. He is allowed to continue his career, and we are allowed to remind him of his abhorrent behaviour.
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Sunny vibes this Mother’s Day, started the day with a nice run @UofT campus and now @TorontoMets baseball with @RoShowBaseball. After games cancelled for rain yest, the baseball Gods must be moms! ☺️💕
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Neesha Dhani retweeted
Got the start for @TorontoMets @CPBLeague 3.0 IP 7 Ks 0 ER. Looking forward to the next game! @richleitch47 @RDM_26 @DuncanWatt19 @ding3722 @PrepBaseballON @JoshArcePB @CamAraujoPB
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