@naomicodes

Software Engineer at @benchling building tools for scientists. All opinions my own

 San Francisco, CA
naomiajacobs.me
Joined October 2016
  • Tweets475
  • Following248
  • Followers1.1K
33Media
My group made a game in a weekend for #ludumdare - check it out! It's a crafting/exploration game and I think it's super cute (I did all the art). One reviewer said "i was planning on only testing the game but I got sucked in for 30 min", go try it! ldjam.com/events/ludum-dare/…
Cover art for our game Incorporeal. It shows a little cottage in the center surrounded by various crystals, demons, and golems

ALT Cover art for our game Incorporeal. It shows a little cottage in the center surrounded by various crystals, demons, and golems

130
I know exactly enough vim to get through rebasing safely and not one hotkey more
1
101
Naomi Jacobs retweeted
John Coogan
@johncoogan3 Apr 2024
California building 5 feet of high speed rail
309
1,325
144
19,475
53,718,835
Naomi Jacobs retweeted
anu
@anuatluru26 Mar 2024
i’m a strong believer in the power of “granny hobbies” to improve your mental health (and detox from digital everything) reading, knitting, gardening, crafting, cooking, baking, board games, sewing, birdwatching, playing cards, drinking tea …
189
8,526
945
41,361
2,319,286
This is actually a pretty good summary of the excellent Orwell essay “Politics and the English Language” orwellfoundation.com/the-orw…
zxy
@zelinarxy25 Mar 2024
english has a cool built-in heuristic for detecting bullshit are most of the nouns and verbs being used latin/greek or germanic in origin? if germanic, the things being discussed are probably real physical actions and things: tree, walk, cow, shit, fall, wood, buy, leg, go
189
Hell yes! Mayor London Breed partnered with 7-Eleven on a new initiative to bring Japanese onigiri to convenience stores in San Francisco. I’m beyond thrilled! Got in line early yesterday and snagged one 🍙 Thank you #7eleven
A person holding a packaged onigiri with a 7-Select label for salmon onigiri. On the label there's a picture of the mayor and next to it it says "It All Starts Here". There's also Japanese text that says サンフランシスコ (San Francisco) and 市長の選択 (Mayor's Choice).

ALT A person holding a packaged onigiri with a 7-Select label for salmon onigiri. On the label there's a picture of the mayor and next to it it says "It All Starts Here". There's also Japanese text that says サンフランシスコ (San Francisco) and 市長の選択 (Mayor's Choice).

Readers added context they thought people might want to know
This tweet is false. There is no partnership between the mayor and 7-11 and these onigiri are not being sold. The tweet author is a “conceptual artist” who created the packaging and made up the backstory. sf.eater.com/2024/3/22/2410…
161
349
696
3,568
1,544,103
From lab to approval in 11 years 🧬 And the thing is, medical applications of CRISPR are just getting started... Just yesterday, the @doudna_lab released two juicy preprints on improved delivery methodologies for CRISPR editing machinery: 1. Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 RNP [1] 2. Engineering self-deliverable ribonucleoproteins for genome editing in the brain [2] In the first paper, they took a thermostable variant of the Cas9 enzyme from a thermophilic bacteria (Geobacillus stearothermophilus), and used directed evolution to engineer >100x greater editing efficiency. This thermostable Cas9 could be more efficiently encapsulated in LNPs, meaning that the actual protein could be delivered in a scalable vector instead of mRNA encoding the protein. This has potential benefits for avoiding immune activation and having potentially higher editing efficiency—the translation efficiency of the mRNA can be a bottleneck. They demonstrated in vivo lung and liver targeting (@justsaysinmice). The second preprint was also very cool. What if CRISPR could just deliver itself (almost like an antibody or other biologic) instead of being packaged in the first place? To achieve this, they screened for self-delivering Cas9 proteins that were fused to cell-penetrating peptides (CPPs) that could help escort them into cells. They showed some POC data for in vivo delivery into the brain via injection into mice. It's absolutely insane to see the pace of progress for CRISPR therapeutics. From basic research result to a new approved modality in 11 years. Just a day before the approval, a pair of brand new delivery strategies released from a single lab. Genomic medicine is only just getting started... What a time to be a biologist! [1] doi.org/10.1101/2023.11.15.5… [2] doi.org/10.1101/2023.11.15.5…
This Post is from an account that no longer exists. Learn more
2
56
4
285
64,405
ESTIMATION GUIDE - get a dev to estimate - increase the number and time unit by one 10 minutes -> 11 hours 3 hours -> 4 days 1 week -> 2 months
83
582
104
4,985
634,077
Sprints
13
315
40
1,793
156,243
📢 Hallo women engineers! Want to learn what it's like to work in biotech? Come hang out at @benchling's HQ on March 29th to hear me and my awesome coworkers talk on a panel. No bio experience needed! events.benchling.com/enginee…

Engineering for Impact: Women at the Intersection of Tech & Bio

Join us for "Engineering for Impact: Women at the Intersection of Bio and Tech" at Benchling in San Francisco! Hear from a diverse panel of five women engineers at Benchling, who will share their...

events.benchling.com
1
119
Never underestimate the power of copy The copywriter behind Slack’s update jargon deserves a monumental raise
46
2,020
162
21,000
1,062,248
A reality that most devs working at large companies take time to appreciate: Personal connections tend to make things easier: the larger the company, the more so. The larger the company, the more noise every team has to cut through. These connections help cut through the noise.
11
37
6
622
110,576
Oh, right, useful details: this will be at @benchling 's HQ in SF on March 29th
1
1
90
Oops, sorry folks! I got too excited about the event and shared too early. Turns out we have a sign up limit and I wasn't supposed to share with the whole internet 😅- I'll repost if we can open it up more broadly.
74
Naomi Jacobs retweeted
Benchling
@benchling2 Mar 2023
Thanks @FastCompany for naming us on the Most Innovative Companies of 2023! We’re honored to be #3 in North America, alongside biotech winners @RecursionPharma & @metagenomi, who are pioneering breakthrough innovations for a better world. fastcompany.com/90848912/mos… #FCMostInnovative
6
1
8
4,255
Naomi Jacobs retweeted
Alex Telford@Atelfo26 Feb 2023
New blog post! I looked at 20 years of data on pharmaceutical blockbusters and what it tells us about the past, present, and potential future of the industry atelfo.github.io/2023/02/26/…
8
26
4
144
50,822
i've been skeptical on the AI stuff but this is a pretty strong showing 🪱💕
16
266
22
2,686
183,740
My friends and I made a video game in a weekend! It's fun and quick (< 3 minutes) and it works in your browser; go play it! It's DUNE themed! ldjam.com/events/ludum-dare/…
1
244
Naomi Jacobs retweeted
Dan Luu@danluu16 Nov 2022
One of the things that I think is sad about the decimation of Twitter eng is that Twitter was doing a lot of interesting (and high ROI) engineering work that, at younger companies, is mostly outsourced to "the cloud" or open source projects A few examples off the top of my head:
Dan Luu@danluu29 Sep 2021
The value of in-house expertise danluu.com/in-house/
An alternate title for this post might be, "Twitter has a kernel team!?". At this point, I've heard that surprised exclamation enough that I've lost count of the number times that's been said to me (I'd guess that it's more than ten but less than a hundred). If we look at trendy companies that are within a couple factors of two in size of Twitter (in terms of either market cap or number of engineers), they mostly don't have similar expertise, often as a result of path dependence — because they "grew up" in the cloud, they didn't need kernel expertise to keep the lights on the way an on prem company does. While that makes it socially understandable that people who've spent their career at younger, trendier, companies, are surprised by Twitter having a kernel team, I don't think there's a technical reason for the surprise. Whether or not it has kernel expertise, a company Twitter's size is going to regularly run into kernel issues, from major production incidents to papercuts. Withou...

ALT An alternate title for this post might be, "Twitter has a kernel team!?". At this point, I've heard that surprised exclamation enough that I've lost count of the number times that's been said to me (I'd guess that it's more than ten but less than a hundred). If we look at trendy companies that are within a couple factors of two in size of Twitter (in terms of either market cap or number of engineers), they mostly don't have similar expertise, often as a result of path dependence — because they "grew up" in the cloud, they didn't need kernel expertise to keep the lights on the way an on prem company does. While that makes it socially understandable that people who've spent their career at younger, trendier, companies, are surprised by Twitter having a kernel team, I don't think there's a technical reason for the surprise. Whether or not it has kernel expertise, a company Twitter's size is going to regularly run into kernel issues, from major production incidents to papercuts. Withou...

28
579
166
2,283
Naomi Jacobs retweeted
Vega Shah
@dr_alphalyrae9 Nov 2022
engineers and UI/UX people laid off by twitter, meta and other big tech companies should join life sciences software building efforts. their skills are precious here and can contribute to something more meaningful to humanity compared to adtech and social media.
10
41
6
244
Load more