@mx_million
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Medicinal Chemist at Bristol Myers Squibb // PhD with @baranlabreads // Amateur Athlete with Team BAA 💛💙🦄
Cambridge, MA
Joined April 2011
- Tweets1.1K
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⚡ Crash course in modern echem out now! Here, we learn about echem against the back drop of modern case studies!⚡️
Thank you @MatthewHorwitz1 and the rest of the team at Synthesis Workshop for the invitation!
youtu.be/pBW4xHF2bBw
This reagent and its corresponding coupling reaction with hetArBr’s has to be one of the most general modern reactions I have leaned on as a med chemist recently. E-rich, e-poor, 5,5-fused heterocycles, naphthyridines, all with basic N elsewhere all work. Hasn’t failed me yet…
These prices are no joke! #nofoolsday High quality materials, same-day shipping, custom sizing to support your projects #knightchem #turboboostyoursynthesis
What a wonderful weekend of chemistry at @ChemistryBC ! It was a pleasure to represent @bmsnews and support the lecture series in organic synthesis! This department will forever hold a special place in my heart. I hope we can continue to share time like this together! 🦅
Max Palkowitz retweeted
Aryl Hydrazines: Convenient Homogenous Reductants for Cross-Coupling. A great collaboration with the Blackmond lab and Abbvie, appearing today in @ChemRxiv : chemrxiv.org/engage/chemrxiv…
I logged into twitter for the first time in months to see what my homies were cooking up… only to see they knew the shape of italy…. @Support
Phenomenal collab!
Diversity is essential for drug discovery, but how to Maximize diversity and minimize the molecular weight gain is the daily challenge in medichem. CH editing at multiple sites is the most promising approach. On a medichem project at BMS with 7 CH bonds: pubs.acs.org/articlesonreque…
Max Palkowitz retweeted
Diversity is essential for drug discovery, but how to Maximize diversity and minimize the molecular weight gain is the daily challenge in medichem. CH editing at multiple sites is the most promising approach. On a medichem project at BMS with 7 CH bonds: pubs.acs.org/articlesonreque…
Max Palkowitz retweeted
Using protein native backbone as ligand for organometallic catalysts without attaching ligands to protein is long sought after. Our MPAA ligand provides a perfect avenue to achieve this, showing high mono-selectivity: Nature Catalysis: rdcu.be/eETI8
What @MatthewHorwitz1 and his team at Synthesis Workshop have built over the years is an outstanding contribution to broader advanced organic chemistry education and the community as a whole.
Bravo Synthesis Workshop and bravo Matt for bring us all together.
Today after years of work and a tight collaboration between >40 chemists in academia and industry, we are thrilled to share the story of how our Advanced Organic Chemistry course and other courses were created in the Journal of Chemical Education!
Link: doi.org/10.1021/acs.jchemed.…
Another summer, another amazing intern! Great to work with David and can’t wait to share what he has been up to!
Max Palkowitz retweeted
Congrats to Zi and team on the publication of our study on a redox mediator strategy to electroreductively harness Fe(I) in alkyne semi-hydrogenation! This work is now published in @ACSCatalysis - stay tuned for more from #TeamFe. #chemtwitter #newPI
pubs.acs.org/doi/10.1021/acs…
Max Palkowitz retweeted
Thank you @mx_million for the generous comments! We’re thrilled to see such excitement from the community!
This is how you enable uptake of a new method! Hats off to the Knight Chemicals team for making a hydrazides coupling starter kit tailor made for medicinal chemists! Obviously I’m biased since I adore @BaranLabReads chemistry and the folks that develop it but dang what a product.
This is how you enable uptake of a new method! Hats off to the Knight Chemicals team for making a hydrazides coupling starter kit tailor made for medicinal chemists! Obviously I’m biased since I adore @BaranLabReads chemistry and the folks that develop it but dang what a product.
Max Palkowitz retweeted
A small step for @NoelGroupUvA, one giant leap for the community.
Inspiring work for all the chemistry automation field. Always #GoWithTheFlow
New @ChemRxiv preprint!
RoboChem-Flex is a powerful, low-cost (<5k EUR), modular self-driving lab for chemical synthesis
We showcase 6 studies (photochemistry, biocatalysis, electrochemistry & more), all optimized with different configurations & ML
🔗chemrxiv.org/engage/chemrxiv…
Max Palkowitz retweeted
New Paper Alert! 🚨
Check out the latest work from @JPosz, @AnaghaVNair1, and @RVanHoveln, @KBrownLab on @J_A_C_S! Synthesis of Borylated Orphaned Cyclopropanes through a Boron-Enabled Cycloisomerization Reaction #TeamEnT @indianastate @IUBChemistry
pubs.acs.org/doi/10.1021/jac…
Max Palkowitz retweeted
One Ligand three CH birds. Temporal control is key for activating three CH on different sites, just like symphony, otherwise will be a mess instead of structure oriented CH reaction: pubs.acs.org/articlesonreque…
Max Palkowitz retweeted
Simplifying Synthesis with Radical Cross-Coupling | drughunters.com/44dDB9V
The recording of Phil Baran's (@BaranLabReads) Flash Talk, "Simplifying Synthesis with Radical Cross-Coupling" is now available on our YouTube Channel.
Phil highlights how his group combines biocatalysis and decarboxylative cross-coupling reactions to rapidly construct complex saturated heterocycles, structural motifs of high value in drug discovery, yet traditionally challenging to synthesize.
He also discussed the wide application of sulfonyl hydrazides as versatile radical precursors for redox-neutral cross-coupling reactions. These reagents, easily prepared from common ketones and alcohols and commercially available, can be used to generate diverse radical intermediates without needing external oxidants or reductants.
Watch the full Flash Talk now and don't forget to share it with a colleague who'd enjoy learning more about how radical chemistry could reshape approaches to complex molecule synthesis: drughunters.com/44dDB9V
Mayones 40th anniversary Hydra #12/40. One of the most spectacular builds ever…
@MayonesGuitars
