@mutatoni

Group leader at @ibv_csic. Mutating proteins to understand their language and how it goes wrong in genetic diseases. Previously PD at @CRGenomica, PhD @MRC_LMS.

 València
mutationalscanning.ibv.csic.es/
Joined February 2018
  • Tweets131
  • Following627
  • Followers269
4Media
Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by @BenLehner and Toni Beltran @mutatoni is out in @Nature. ✍️ Illustration by @QueraltTolosa
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Ben Lehner@BenLehner
26 Sep 2024
The genetic architecture of protein stability by @aj4re @ainamartiaranda @cristonah @ToniBeltran13 @JoernSchmiedel nature.com/articles/s41586-0… @CRGenomica @sangerinstitute @ALLOXbio

The genetic architecture of protein stability

Nature - By experimentally sampling from sequence spaces larger than 1010 and using thermodynamic models, the genetic structure of at least some proteins can be well described, indicating that...

nature.com
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Ben Lehner@BenLehner
13 May 2024
Excited to share @AlbertIltirda's randomisation of protein cores at scale: Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution with @aj4re @CRGenomica @sangerinstitute biorxiv.org/content/10.1101/…

Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution

Protein folding is driven by the burial of hydrophobic amino acids in a tightly-packed core that excludes water. The genetics, biophysics and evolution of hydrophobic cores are not well understood,...

biorxiv.org
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Jamie Hackett@hackettlab
9 May 2024
How do chromatin modifications quantitatively impact gene expression? How do sequence variants or combinatorial marks influence relationships? We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵… nature.com/articles/s41588-0…
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Jamie Hackett@hackettlab
1 May 2024
The gut microbiome influences metabolites, hormones and immune function Perturbing gut microbiota therefore impacts homeostasis across somatic tissues Could it also affect the reproductive system - and even offspring? See our results👇& tweetorial🧵 rdcu.be/dGpoc
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AEMET
@AEMET_Esp
30 Apr 2024
Replying to @AEMET_Esp
A falta de los datos definitivos de abril, el año 2024 es uno de los dos más cálidos de la serie histórica, con unos valores muy similares a los de 1997, cuyo primer cuatrimestre es el más cálido de la serie. Por detrás de 2024 quedarían 2020 y 2023.
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Ben Lehner@BenLehner
30 Apr 2024
Replying to @BenLehner @CRGenomica @sangerinstitute
That's the Src kinase domain alone. Here's the allosteric map of the kinase domain in the context of the full-length protein (+ SH2, SH3, SH4 etc).
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Ben Lehner@BenLehner
30 Apr 2024
Thread by @ToniBeltran13 about the Src kinase allosteric map. And here is one view of the map. @CRGenomica @sangerinstitute
Toni Beltran@mutatoni
30 Apr 2024
I’m super happy to finally share what I have been up to the last few years at the @BenLehner lab in Barcelona! We made lots of double mutants on the kinase domain of Src to study allosteric communication.
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I’m super happy to finally share what I have been up to the last few years at the @BenLehner lab in Barcelona! We made lots of double mutants on the kinase domain of Src to study allosteric communication.
Ben Lehner@BenLehner
30 Apr 2024
The allosteric landscape of the Src kinase. Amazing work from @ToniBeltran13 with @aj4re biorxiv.org/content/10.1101/… @CRGenomica @sangerinstitute

The allosteric landscape of the Src kinase

Enzymes catalyze the reactions of life and are the targets of most small molecule drugs. Most drugs target conserved enzyme active sites, often causing problems of specificity and toxicity. Targeting...

biorxiv.org
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This complete allosteric map also allows us to take an unbiased look at the surface of the kinase. Many surface pockets are enriched in inactivating allosteric mutations, and we think these might be interesting sites to target with drugs in the future! 💊
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I'm super grateful to have had the support of all the Lehner lab members, and of course of @aj4re and @BenLehner. We are super excited to expand this approach to other kinases and enzymes next! 🧬🧑‍🔬💻
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Excited to share a new, MUCH IMPROVED version of our deep indel mutagenesis (DIM) manuscript: biorxiv.org/content/10.1101/… See the thread below for details.

Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein...

Amino acid insertions and deletions (indels) are an abundant class of genetic variants. However, compared to substitutions, the effects of indels on protein stability are not well understood and are...

biorxiv.org
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Taraneh@taraneh_z
26 Apr 2024
Very happy to share what I've been working on in Barcelona with @BenLehner ! We made many (>400k) mutations in a disordered peptide and the globular domain it interacts with to gain a comprehensive map of how specificity is encoded in a partially fuzzy protein interaction (1/n)
Ben Lehner@BenLehner
26 Apr 2024
Excited to share @taraneh_z's preprint: A complete map of specificity encoding for a partially fuzzy protein interaction biorxiv.org/content/10.1101/…

A complete map of specificity encoding for a partially fuzzy protein interaction

Thousands of human proteins function by binding short linear motifs embedded in intrinsically disordered regions. How affinity and specificity are encoded in these binding domains and the motifs...

biorxiv.org
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Toni Beltran retweeted
Ben Lehner@BenLehner
26 Apr 2024
Excited to share @taraneh_z's preprint: A complete map of specificity encoding for a partially fuzzy protein interaction biorxiv.org/content/10.1101/…

A complete map of specificity encoding for a partially fuzzy protein interaction

Thousands of human proteins function by binding short linear motifs embedded in intrinsically disordered regions. How affinity and specificity are encoded in these binding domains and the motifs...

biorxiv.org
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Excited to finally share some of my PhD work on quantifying the effects of indel mutations on protein stability and function using deep mutational scanning. From sunny @CRGenomica together with @ToniBeltran13 and guidance from @BenLehner biorxiv.org/content/10.1101/…

Deep indel mutagenesis reveals the impact of insertions and deletions on protein stability and...

Amino acid insertions and deletions (indels) are an abundant class of genetic variants. However, compared to substitutions, the effects of indels are not well understood and poorly predicted. Here we...

biorxiv.org
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Ben Lehner@BenLehner
9 Oct 2023
New preprint from the lab: Deep indel mutagenesis reveals the impact of insertions and deletions on protein stability and function. First paper from Magda with @ToniBeltran13 biorxiv.org/content/10.1101/…

Deep indel mutagenesis reveals the impact of insertions and deletions on protein stability and...

Amino acid insertions and deletions (indels) are an abundant class of genetic variants. However, compared to substitutions, the effects of indels are not well understood and poorly predicted. Here we...

biorxiv.org
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Niccolò Arecco@NccAcc
1 Dec 2022
Interested in spending 5 months in @CRGenomica Barcelona 🌊and learning how to CRISPR ✂️🧬? We @mirimiam are looking for a paid 💸 intern that will work on genome engineering using stem cells. Salary & relocation flights covered. More details here: crg.eu/en/content/training/u… 1/2
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