@mulecc
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Interested in Acinetobacter baumannii insertion sequences 🧬🦠🧫
London, England
Joined August 2009
- Tweets171
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So much for a short project… but our work over the last few years has seen the light of day!
Turned into a nice project that taught me a lot, in particular about DNA supercoiling.
In our most recent work David Forrest has discovered a widespread mechanisms linking transcription initiation to DNA supercoiling...
nature.com/articles/s41467-0…
Charles Cooper retweeted
Well done @mulecc - your PhD work just published 😀nature.com/articles/s41467-0…
I think we've only scratched the surface with this... H-NS allowing bacteria to direct their own evolution. Exciting times ahead...
After finally recovering from celebrations, a big thank you to all of @GraingerLab for helping me get my PhD, and thank you to Carsten Kröger and @JessicaMABlair for examining ☺️
Charles Cooper retweeted
Really excited to share this. A massive effort from @mulecc.
We find that H-NS isn't just for gene silencing. All this time it's been busy capturing transposons, and inserting them into bound DNA.
We think there are some big implications (1/4)
biorxiv.org/content/10.1101/…
Charles Cooper retweeted
It was decided this would have been so not Rainbow Rhythms, so Peep Show will remain on Netflix.
hi @NetflixUK - the date warning badge has now been removed from Peep Show...can you confirm??
Charles Cooper retweeted
Excited to be doing some public engagement on Saturday at #CoCoMAD with the @Micro_Mad team! Please retweet and give us a follow to keep up with us over the weekend!
Very excited to be attending CoCoMad '23 @CotteridgePark this Saturday representing @IMIBirmingham 🧫Come and say hi to our team @pRobM91 @LillyCummins_ @freyaallen__ @roscobacterium @IzziePotterill
Charles Cooper retweeted
The @GraingerLab is finally back from the GRC Mechanisms of Microbial Transcription conference. Learned loads, met some great folk and saw abit of Boston. – at Birmingham, England
Charles Cooper retweeted
Catch me tomorrow at 12:00 at the Tuberculosis session talking about arabinose, phage, and and new GHs!
@MicrobioSoc
Charles Cooper retweeted
Happy to announce my first, first author paper has been published in @OUPBioinfo. Our software, ChemGAPP, is a comprehensive analytic package for chemical genomics datasets. Check it out! Thanks to @BanzhafLab, @DaneshMoradi and @mgalactus. academic.oup.com/bioinformat…
Charles Cooper retweeted
Latest paper from the lab, this one's the culmination of @lucas_walker92's PhD. He describes how two TFs can bind the same DNA site to regulate in V. cholerae.
A simple mechanism for integration of quorum sensing and cAMP signalling in V. cholerae biorxiv.org/content/10.1101/…
Charles Cooper retweeted
@Hannahmayyd suffered that we don't have to! ChemGAPP is a very easy to use software package that people without sophisticated programming skills can analyse their chemical genomics data. Check it out.
ChemGAPP; A Package for Chemical Genomics Analysis and Phenotypic Profiling. biorxiv.org/content/10.1101/…
Charles Cooper retweeted
Went n won a poster prize at the Molecular Microbiology conference. So answered a couple of questions about it: – at Birmingham, England
Next up for our interview with recent poster award winners at the 7th Molecular Microbiology conference is David Forrest @fozzz21 for their work ‘No non-sense: Prevention of non-specific transcription in Bacillus subtilis’ @GraingerLab
Read it below 👇
onlinelibrary.wiley.com/do/1…
Charles Cooper retweeted
Hypertension is a risk factor for neurodegeneration, and the choroid plexus may play a critical role in this process. But how can we use MRI to look at the damage non-invasively? Find out more today: doi.org/10.3389/fnmol.2022.9…
#AD #MRI @CABI_UCL 🧠🧲
Charles Cooper retweeted
🧵on the latest @DETECTIVE_AMR manuscript, which might be my favourite so far. It's about a quirky group of plasmids that accumulate and disseminate all sorts of accessory genes in Acinetobacter... 1/20 microbiologyresearch.org/con…
Charles Cooper retweeted
I mis-clicked on one of my 150 open tabs and it happened to be a tab that's been open since 2019 with a paper that has a solution to the exact research problem I've been puzzling over today. This is the moment I've been waiting for and I've decided to never close any tabs again
Charles Cooper retweeted
First bit of work from my PhD looking at sequence type pangenomes and how they vary in structure and content - very pleased to have this out! 🥳 @alanmcn1 @DrRebeccaJHall @jomcinerney @chris_h_connor
biorxiv.org/content/10.1101/…
Charles Cooper retweeted
E. coli packs a genome into cell 1/1000th of its length, duplicates it, and sends a copy to each daughter cell every twenty minutes. It's humiliating.
Charles Cooper retweeted
I learnt so much writing this review with @AnnSnaith @DrRebeccaJHall @alanmcn1 🤓 Spoiler: enhanced colonisation capabilities may be key for MDR clone evolution link.springer.com/article/10…
