Data Rule Everything Around Me.
San Francisco, CA
Joined May 2018
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Exciting Inhibitory Neurons!
Our paper from @Lab_Pollen @brainevodevo @yimmieg @LabNowakowski @UCSF is out today in @Nature! nature.com/articles/s41586-0…
Also a less technical blog about the findings: medium.com/@matthew.schmitz/…
If you have questions, I'm happy to GABAbout it!
We're extremely excited to dive deep on whale brains! Thank to the Keck Foundation for believing in a project that isn't traditionally "fundable". Also thank you to @brainevodevo, Robin Baird from Cascadia and Barbie Halaska from @TMMC , without whom we wouldn't have even begun!
Allen Institute and @UCSF researchers are working with marine mammal conservation organizations to demystify the cetacean brain thanks to funding by the Keck Foundation.
Read the research abstract: wmkeck.org/wp-content/upload…
@mtvector1 @brainevodevo
Matthew Schmitz retweeted
We investigate cellular differences between humans and chimpanzees using CRISPRi-based genetic screens sciencedirect.com/science/ar…
Matthew Schmitz retweeted
A short review/opinion I wrote with @brainevodevo, "identifying large-effect mutations–should they exist–and defining the effect size distribution for a measurable phenotype are central challenges facing genetic studies of human evolution” sciencedirect.com/science/ar…
Matthew Schmitz retweeted
Excited to finally release the @biorxivpreprint of my first ever first author paper! 🚨🥳🥳🚨biorxiv.org/content/10.1101/… Any enhancer lovers in the feed!?! You know what time it is-- We're going deep! ./tweetorial.sh👇🧵
Matthew Schmitz retweeted
Scoop: Stanford biology professor Hunter Fraser was arrested and charged with domestic violence.
Fraser allegedly threw a woman on the ground and later slammed a door into her, court records show. Fraser pleaded not guilty. @StanfordDaily
stanforddaily.com/2022/10/04…
Matthew Schmitz retweeted
Big presence from my grad program at #ISSCR2022. Couldnt even wrangle them all together for a pic. Best Developmental and Stem Cell Program in the world, might be biased though. #ucsf #ISSCR2022 #stemcell #gradschool #phdlife
Matthew Schmitz retweeted
My second PhD paper is out! Check it out to learn about some cool human development and astrocyte biology 🥳
Pleased to share the latest study by @InBay01 @crcadwell @sohallab @mattgkeefe @DavidSh90791209 and Kevin Donohue revealing complex developmental origins of human astrocytes science.org/doi/10.1126/scie…
People don't realize how important it is to have a mantra to whisper while doing bioinformatics. Here's mine:
Matthew Schmitz retweeted
Canonical Ubuntu 22.04 LTS Jammy Jellyfish is here!
Download it here now!
ubuntu.com/download/desktop
I've learned many things in the last year, but einsum is hands down the most important coding tool I've picked up recently
youtube.com/watch?v=pkVwUVEH…
Matthew Schmitz retweeted
In 2018, we developed mux-seq and demuxlet to enable population-scale single-cell sequencing. Today, excited to share our paper in @ScienceMagazine where we deployed mux-seq to profile 1.2M immune cells from 162 lupus patients and 99 healthy controls: science.org/doi/full/10.1126…. 1/n
Cool new bioRxiv from friend and fellow UCSF graduate student @marsh_bp on everyone's favorite alien pancake, the #placenta! Glad someone's taking a stand and not dismissing the smooth chorion :) biorxiv.org/content/10.1101/…
3/ We use RNA velocity to link initial to terminal classes, largely recapitulating known relationships and also suggesting a number of new developmental relationships, like a link between OB PGCs and "eccentric spiny neurons" @your_arpy
9/ Primate decreased reliance on smell -> Smaller olfactory bulb -> Excess OB neurons go to the cortex to be "reused" in white matter <- Expanded cortex means expanded regions where OB neurons are born. <- Primate expanded cortex for thinking with a long development for learning