University of Cambridge
Joined August 2010
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The effectiveness of BCG will be considerably reduced if there is a source of unmanaged infection in contact with herds - another reason the UK situation is much more nuanced. Benefits could take decades to see depending on rates of circulation between hosts.
Our result is important as infection with bTB is chronic, the direct protection is not enough to reduce transmission enough to eliminate infection- you need the reduction in infectiousness as well.
Vaccination could be effective in UK as well, but would be much slower than current controls and also pose risks of making situation worse depending on relative efficacy of DIVA tests: nitter.cf/monkeymyshkin/status/1…
This is only one small step on the path to deployment - particularly in managed populations such as the UK where vaccination depends more on validation of new diagnostic tests to differentiate vaccinated from infected animals than efficacy of the vaccine dx.plos.org/10.1371/journal.…
What we measure is the direct effect of BCG to reduce rates of transmission. This is what matters most to control disease in a population but individual protection infection is not great - most animals in study had some evidence of lesions.
Good moos about bovine TB with the naked scientists at 7.33 tinyurl.com/24kgaq7l
Particularly satisfying to finally address this question after developing the design with Mart de Jong at Wageningen @WUR to address the intractable challenge of carrying out such studies in the UK doi.org/10.7554/eLife.27694
Thanks to our fabulous colleagues at the Animal Health Institute and Addis Ababa University in Ethiopia, have the rare opportunity to share good news for the prospects of using cattle vaccination to control bovine Tuberculosis.
science.org/doi/10.1126/scie…
Very pleased to share a a small study a long time in the making:
Colonization and transmission of Staphylococcus aureus in schools: a citizen science project microbiologyresearch.org/con…
After a pandemic-sized hiatus, pleasure to be back in person teaching the latest regeneration of our course on mathematical modelling of infectious diseases for @vaccineimpact #mathspartylivesagain
We cover the whole process of modelling from the basics of calculus, an introduction to programming in R through to estimating dynamic models to data. Course is generously supported by VIMC, with a relatively short window so apply now!
Extremely pleased to resurrect our intensive short course on disease dynamic modelling. Slightly shorter, leaner and with a new focus on vaccination - this is an opportunity for biologists of all flavours to learn about the nuts and bolts of disease dynamic models.
Mathematical Modelling for Vaccine-preventable Diseases short course run by VIMC @vaccineimpact & University of Cambridge for participants from LMICs. Apply now (closing 8th July) forms.gle/AWrnX2yjMiXvjp5w8
Seems a lifetime since I worked on Campy, but super interesting and lovely to see this. In line with the lag phase being about transmission rather than dose-response? Also stoked to see your recent modelling paper - do still wish our earlier attempt had worked out better!
Key topic - not just for Covid-19, but epidemiological modelling more generally. Our research is both on and for the benefit of society. Open data and code needs to be the baseline we start from, rather than just an aspirational target.
Wishing we could all have met in person, first up Nik Cunniffe giving us a virtual refresher on our basic calculus!
Maths vs. Covid-19, with Prof Julia Gog gresham.ac.uk/lectures-and-e…
A very different group photo for our final Wellcome Trust Advanced Course on Disease Dynamics. Very sad to be moving on after 10 years, but many thanks to all the instructors and students over the years for making this course a success (and highlight of my year). #FinalMathsParty
Setting for final Wellcome Advanced Course for Mathematical Modelling of Infectious Diseases less salubrious than the Genome Campus (and dissappointedly cake free) but the Maths is still flowing digitally! #MMIDD2021 #FinalMathsParty
Final year of our course introducing modelling and disease dynamics for non-specialists goes virtual! Learn to think like a modeller, code your own models and link them to data @IDDjobs coursesandconferences.wellco…
Our final Wellcome course on mathematical modelling for infectious disease dynamics is going virtual in March 2021. What better time to learn how simple mathematical models can be used to understand and control epidemics? coursesandconferences.wellco…