@mo_brainer

Neuroscientist studying the circuits of perception and decision-making 🧠 🇦🇺 🇺🇸

 Melbourne, Australia
mo-laboratory.com/
Joined September 2012
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  • Following128
  • Followers132
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Our review on transthalamic pathways is now out in @CommsBio. We discuss emerging evidence they contribute to perception and decision-making, and why it remains so difficult to isolate their function behaving animals. Studying circuit function is hard. nature.com/articles/s42003-0…
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Baris Kurtkaya@bariskurtkaya
May 1
For years, neuroscientists faced a choice: record what a neuron does in a living animal, or read its molecular identity postmortem. Same cells, both readouts, at scale? Out of reach. TRU-FACT closes that gap. 🧵
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That’s a wrap on the 4th Optogenetics Australia conference 2025! Thank you to the speakers, sponsors, attendees, organising committee and everyone in between for an illuminating 💡conference. OptoAus 2027 is looking for a home so if you’re interested, get in touch on the website
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Inspiring Plenary Speech by A/Prof Jennifer Rodger on Repetitive TMS for sceptics at #ANS2024, Chaired by A/Prof Ann-Maree Vallence! ⁦@AusNeuroSoc⁩ ⁦@_hellewell_⁩
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🧠👂🫰Our paper on the limitations of other sensory modalities to influence a sensory cortex is out today! 🎉 cell.com/neuron/fulltext/S08…

Stability of cross-sensory input to primary somatosensory cortex across experience

Kato and Bruno show that, despite responding to sounds, rodent primary somatosensory cortex (S1) encodes neither the identity of pure auditory stimuli nor simultaneous auditory-tactile stimulus...

cell.com
Randy Bruno
@TheBrunoCortex
12 Aug 2024
Perception is multimodal—we recognize objects in the world by combining touch, sight, sound, smell, and taste. Primary sensory cortical areas (S1, V1, A1, …) respond to other modalities. Could a primary area bind together different modalities, like an association cortex? 🧵
genetics.utah.edu

ALT genetics.utah.edu

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Nice results. You can't understand cortex w/o the thalamus Primate thalamic nuclei select abstract rules and shape prefrontal dynamics biorxiv.org/content/10.1101/… #Neuroscience They also find a spectrolaminar cortical motif like this study: nature.com/articles/s41593-0…
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We're thrilled to introduce the #ANS2024 Plenary Lecture speaker, A/Prof Jenny Rodger of the @PerronInstitute. She will discuss repetitive transcranial magnetic stimulation for sceptics: how understanding mechanisms drives translation and innovation ⚡️
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Steffen Wolff@SBE_Wolff
27 Sep 2024
The Wolff Lab is looking for a #Postdoc for a NIH-funded project to study how distinct learning systems interact. Catch me at SfN or reach out via email if you are interested! #Neurojobs #AcademicJobs
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Sonja Hofer@SonjaBHofer
11 Sep 2024
Great paper describing brain-wide coordination of neural activity during decision making
SWC@SWC_Neuro
11 Sep 2024
Researchers at SWC have mapped how the brain transforms sensations into action. Read the story: sainsburywellcome.org/web/re… Full paper in @Nature: nature.com/articles/s41586-0…
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Academics will write "interestingly" and then impart the driest piece of information you have ever heard in your life
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What is the nature of sensory prediction error signals in the neocortex? Our research published in @Nature reveals that these error signals are amplified responses to unexpected inputs, mediated by a cooperative thalamocortical circuit mechanism! 1/4 nature.com/articles/s41586-0…

Cooperative thalamocortical circuit mechanism for sensory prediction errors

Nature - Experiments in mice show that a cortico-thalamic circuit generates prediction-error signals in primary visual cortex that amplify visual input that deviates from animals’ expectations.

nature.com
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Formatting guide: "use up to 4 modest display items (figures and tables)" The supplementary information:
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A study published in @Nature reveals that abstract representations in the human brain, particularly in the hippocampus, help us generalize from past experiences to new situations. go.nature.com/3TiAnfx
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We are excited to announce @DrLizzieManning as a speaker at the 4th Optogenetics Australia Meeting in 2025! Lizzie's groundbreaking research uses cutting-edge techniques like optogenetics and aims to bridge the gap between preclinical models and clinical practice. #OptoAus2025
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Graham Pluck@DrGPluck
8 Aug 2024
It's the cortical-subcortical circuits that matter, as always: nature.com/articles/s41467-0…

A transthalamic pathway crucial for perception

Nature Communications - Perceptual signaling is understood to involve direct cortical projections. Here, the authors show that cortical signaling via higher order thalamus is necessary for...

nature.com
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Nice dissection of feedforward cortico-thalamo-cortical pathways shows how they are distinct and influential routes of sensory processing.
CLaE
@leafs_s
8 Aug 2024
Nature Communications A transthalamic pathway crucial for perception nature.com/articles/s41467-0…

A transthalamic pathway crucial for perception

Nature Communications - Perceptual signaling is understood to involve direct cortical projections. Here, the authors show that cortical signaling via higher order thalamus is necessary for...

nature.com
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Jennifer Rodger of @PerronInstitute @UWAresearch is the ANS Plenary Lecturer. A/Prof Rodger's talk title is "repetitive transcranial magnetic stimulation for sceptics: how understanding mechanisms drives translation and innovation" #ANS2024
Sarah Hellewell@_hellewell_
8 Aug 2024
Have you seen the amazing plenary speakers announced for the Australasian Neuroscience Society @AusNeuroSoc Annual Meeting? #ANS2024 ans.org.au/ans-asm/plenary-s…
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Very nice work by @mo_brainer and colleagues,stressing once more the importance of the thalamus 👇
Christina Mo@mo_brainer
6 Aug 2024
Are we too cortex exclusive? 🧠 We found that perceptual decisions depend on a cortical pathway through thalamus (transthalamic), even though corticocortical projections are intact. Transthalamic pathways thus play a major but underappreciated role in perception. 1/5
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Dr Meming@Dr_Meming
7 Aug 2024
Me looking for typos before submitting my paper. Vs me finding them IMMEDIATELY after submitting
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Are we too cortex exclusive? 🧠 We found that perceptual decisions depend on a cortical pathway through thalamus (transthalamic), even though corticocortical projections are intact. Transthalamic pathways thus play a major but underappreciated role in perception. 1/5
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Big thanks to Claire McKinnon and Murray Sherman for seeing this through. This work was a collaboration between the @TheFlorey Institute and the University of Chicago. #cortex #transthalamic #thalamus #calciumimaging #neuroscience #optogenetics #perception #decisionmaking
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Link to paper: nature.com/articles/s41467-0…

A transthalamic pathway crucial for perception

Nature Communications - Perceptual signaling is understood to involve direct cortical projections. Here, the authors show that cortical signaling via higher order thalamus is necessary for...

nature.com
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