@mo5er
 The Netherlands
Joined July 2010
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30Media
Happy to share that I have been awarded the @ESICM Family Partnership Research Award! Our project will focus on investigating new-onset diabetes in ICU survivors. #LIVES2024 #ICU #diabetes #ESICM #umcg #umcgresearch #intensivecarevolwassenen
ESICM@ESICM8 Oct 2024
At #LIVES2024, we celebrate the winners of the 2024 Research Awards 👏 Congratulations to: Martin Dres, @rakiphd, Chantal Boly, @fblancha25, @MarliesOst, Inès Lakbar, @FuestKristina, Timothy Snow, @LouisBoutinMD, @mo5er, Dhupal Patel, Ruchi Gupta Singla (supported by ESICM);
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Why do Drs use treatments that do not work? For many reasons—including their inability to stand idle and do nothing ncbi.nlm.nih.gov/pmc/article… via @jadoust & Late Prof #ChrisDelMar & @bmj_latest
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Svetlana Mojsov helped discover the hormone GLP-1, which led to the development of blockbuster obesity drugs. Now, she’s fighting for recognition. #LongReads scim.ag/41U

Her work paved the way for blockbuster obesity drugs. Now, she’s fighting for recognition

Svetlana Mojsov helped discover the hormone GLP-1. Why has she been excluded from its history?

science.org
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New Review! Interorgan communication networks in the kidney–lung axis by Yohei Komaru, Yun Zhu Bai, Daniel Kreisel & Andreas Herrlich go.nature.com/45XYi7Q
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Online Now: Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue #trends #endocrinology #metabolism dlvr.it/Svg1h7

Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue

Obesity is an independent risk factor for severe COVID-19, yet there remains a lack of consensus on the mechanisms underlying this relationship. A hypothesis that has garnered considerable attention...

cell.com
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Excited to share our review out now in @Trends_Endo_Met Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose ... sciencedirect.com/science/ar… @VasculitisUMCG @Izabelarodenhu1 and Marloes Emous #umcg #mcl – at Groningen, Nederland
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An important, elegant study pinpointing mitochondrial dysfunction in the heart, kidney, liver & lymph nodes after #SARSCoV2 exposure and its clearance in 2 experimental models and people science.org/doi/10.1126/scit… Sets up potential for #LongCovid treatment that needs to be assessed
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Have you ever wondered why some #viruses circulate primarily in the winter and others are more prevalent in the summer? Although we don’t have a clear answer to this question, a combination of factors is likely responsible. A 🧵, also at virology blog. 1/
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Just published: Synopsis of 2023 updated #ARDS guidelines from @ESICM, including the guidelines’ methods, findings, and implications, along with reflections on next steps, by Derek C. Angus, MD, MPH; Christopher W. Seymour, MD, MSc; and @KBibbinsDomingo. ja.ma/3JfcIY8
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GPTKit(dot)ai is a brilliant tool to detect if a text is generated by ChatGPT or written by a human. Especially useful for teachers/educators:
A screenshot of the homepage of GPTKit.

ALT A screenshot of the homepage of GPTKit.

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Our comprehensive review of #LongCovid has just been published nature.com/articles/s41579-0… Phenomenal work by @ahandvanish @LisaAMcCorkell @juliamv @NatureRevMicro
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Delighted our #research on the relationship between circulating adipokines and COVID-19 hospitalization has now been published with @SpringerNature @IntJObesity-a fantastic collaborative effort between researchers @umcg, @AmphiaZKHuis, @MCLeeuwarden rdcu.be/c1qXA
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When kidneys hurt, remote organs also suffer, likely contributing to associated mortality/morbidity... Review focused on most documented/relevant interactions between #AKI & ➡️ immune system ➡️ heart ➡️ lung ➡️ gut ➡️ brain ➡️ liver #FOAMcc on @yourICM 📎 rdcu.be/c0fmq
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Nice work by ⁦@Tollgrinder2⁩, ⁦@Izabelarodenhu1⁩, ⁦@UmcgE⁩ and collaborators- TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to non-infectious immature dengue virus particles | ⁦⁦@PLOSPathogens⁩ journals.plos.org/plospathog…

TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to non-infectious...

Author summary We have previously demonstrated that Toll-like receptor 2 (TLR2), present on the surface of human monocytes, can sense DENV infection leading to the production of soluble inflammatory...

journals.plos.org
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An isolation period of 5 days after Covid is totally inadequate for most people. New report from >63,000 people. Negative rapid tests are an essential guide jamanetwork.com/journals/jam… @JAMANetworkOpen
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Multiplatform Single-Cell Analysis Identifies Immune Cell Types Enhanced in Pulmonary Fibrosis 🔗 bit.ly/3amqWrT
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New Research: Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro: Clinical observations have shown that obesity is associated with the severe outcome of… frontiersin.org/articles/10.… #immunology

Frontiers | Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary...

Clinical observations have shown that obesity is associated with the severe outcome of SARS-CoV-2 infection hallmarked by microvascular dysfunction in the lu...

frontiersin.org
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🦠 Great to see our work now online: Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells frontiersin.org/article/10.3… Great team work: Jelmer, @BramterEllen, @Izabelarodenhu1, @Peter_vd_Voort, @ZonMw, 🧵 1/4
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3/4 Whether ECs become infected by SARS-CoV-2 in vivo remains a topic of debate with many conflicting studies. Until now most studies conclude that ECs might become infected in vivo but that the endothelium is not likely to be the primary or main site of infection.
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4/4 Further in vivo studies are required to elucidate the mechanisms regulating EC dysfunction in COVID-19, and the mechanisms driving severe disease in obese individuals.
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