Associate Professor, Biochemistry and Biophysics, @urochestermed. RNA-targeting CRISPR / RNA acetylation. An Aussie in 'the land of the free'. Music Nerd.
Rochester, NY
Joined December 2015
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1/n After an arduous but constructive peer review process, we’re excited to share the published version of this work. Lots of added goodies: science.org/doi/10.1126/scie…
1/8: Super excited to share our latest pre-print from the lab, where in close collaboration with @kellogg_liz lab we show that through some pore behavior, the CRISPR-Cas13-activated membrane protein CRISPR-Csx28 pulls the plug on bacteriophage infection. biorxiv.org/content/10.1101/…
Mitchell O'Connell retweeted
New post-doctoral research position available in my Phage-host interactions (Phi) laboratory at the @otago in the Department of Microbiology and Immunology. The project is focused on defences against jumbo phages. Please share and if interested apply using the link below.
Woo hoo @Wagnerlab_RNA! Awesome news and well deserved!
Congratulations to RNA biologist Eric Wagner for achieving the rank of #AAASFellow by @AAAS!
Thank you for your extraordinary contributions to science and mentoring the next generation of biomedical researchers.
Read more about Dr. Wagner’s work: urmc.rochester.edu/news/stor…
My department is hiring! We’re looking for faculty in the department of Biochemistry and Biophysics at the University of Rochester. As I can attest, Rochester provides a highly supportive and collaborative environment and is a great place to work/live: jobs.sciencecareers.org/job/…
Mitchell O'Connell retweeted
Excited about phage functional genomics, phage engineering, & microbiome editing? The Cress Lab @UCBerkeley @igisci is hiring postdocs in these areas! Come chat w/ me @VoM_2024 & don't miss my presentation w/ @ben_a_adler in the SynBio session Fri @ 11:20am. Retweets appreciated!
Mitchell O'Connell retweeted
Keep watch… plenty starting to happen with the #CRISPR conference in NZ next February.
Get ready for #CRISPR2025 in #NewZealand. We are fortunate to have Malcolm White @mfwhite2 as our Keynote speaker.
Big congratulations to @ammolinavargas graduating with his PhD, not to mention all the accolades along the way including the Leadership Award for Excellence in Equity and Inclusion bestowed at graduation. We're all very proud of all your accomplishments and we're gonna miss you!
Mitchell O'Connell retweeted
Join us in April in Boston for the 2024 symposium on the immune system of bacteria ! 🧫🧬🥳
Registration now open: kranzuschlab.med.harvard.edu…
Abstract deadline March 4th.
The first FDA approval for CRISPR! A historic milestone! Thanks @URochester_SMD for getting a chance on riff on about this special occasion (unrehearsed and unscripted as you might be able to tell!). #URochesterResearch
.@mitchellrayoco1, asst prof of Biochem and Biophysics, who trained w/ Nobel Prize winner Jennifer Doudna, one of the inventors of the revolutionary gene-editing technology CRISPR, weighs in on today's approval for using CRISPR to treat sickle cell patients. #URochesterResearch
Mitchell O'Connell retweeted
Now @NAR_Open our two back-to-back papers with @mitchellrayoco1 lab! Our #chemcomp paper unravels the #RNA-mediated allosteric regulation in #CRISPR-Cas13a and discloses functional mutations.
academic.oup.com/nar/advance…
@sou_svk @pablitoarantes @ammolinavargas & Amun Patel
Now @NAR_Open our two back-to-back papers with @palermo_lab lab! 1) We show that MD-directed point mutations select against #offtargets in #Cas13a, paving the way for new SNP-detecting #RNA-diagnostics. academic.oup.com/nar/article…
@ammolinavargas @sou_svk @pablitoarantes Amun Patel
And 2) Back-to-back, with @palermo_lab our #chemcomp paper unravels the #RNA-mediated allosteric regulation in #CRISPR-Cas13a and discloses functional mutations.
academic.oup.com/nar/advance…
Love this! Eric has been instrumental helping me stay afloat starting a lab at Rochester. Sitting down almost high school English teacher style going line by line, pen and paper through a grant application has been transformative about how i think to communicate. A true gift!
We are delighted to announce our next RNA Society Member Spotlight!
rnasociety.org/dr--eric-phiz…
Dr. Eric Phizicky has been a Professor in the Department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry in the USA for over 35 years. In this month’s RNA spotlight, written by Dr. Isha Verma, Dr. Phizicky talks about his research, shares his advice to trainees, and also recounts his role as the Senior Editor of the RNA Society’s flagship journal.
Mitchell O'Connell retweeted
The Bio Dept at University of Rochester is hiring a TT Assistant Professor in evolutionary genetics/genomics. Review begins 11/1. Come be our colleague! rochester.edu/faculty-recrui…
Congrats to @ammolinavargas on hitting his thesis defense out of the park yesterday. Very proud PI. We will miss you but excited for what is next!
My department is hiring! We’re looking for faculty in the department of Biochemistry and Biophysics at the University of Rochester. As I can attest, Rochester provides a highly supportive and collaborative environment and is a great place to work/live: jobs.sciencecareers.org/job/…
Excited for this! @ammolinavargas has built an impressive body of work that we're all really proud of!
Mitchell O'Connell retweeted
Cheers to RNA biologist Lynne Maquat for officially receiving the Gruber Genetics Prize @Genetics2023 in Australia for her work on nonsense-mediated mRNA decay. Proud to have you represent @UofR on an international stage! #URochesterResearch @MaquatLab urmc.info/15L
Mitchell O'Connell retweeted
Really great collaboration with @mitchellrayoco1 and his student @ammolinavargas , resulting in the development of new and more specific #crispr Cas13a systems !!
1/n Super excited to share our latest pre-print from the lab, where we reveal important considerations when designing Cas13a-based SNP-detection assays to ensure specificity and anticipate designs caveats. 🧵 biorxiv.org/content/10.1101/…
