
Postdoc in the Berger lab @Penn. Love all things host-microbe epigenetics 🧫🧬🏳️🌈 he/him/his
Knoxville, TN
Joined September 2018
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Sean Callahan, PhD retweeted
Replying to @willaise
@willaise is an awesome scientist (and person and father!). Profound findings and lots to follow up on! Congrats!
My fav finding: transplanting healthy immune cells reduces pathology in other diseased host cells. How does fixing ~10% of the brain help the other 90%?!
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease: @ImmunityCP cell.com/immunity/fulltext/S… #gliadelphia
Sean Callahan, PhD retweeted
Thrilled to share our published @eLife paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @Marisa_Egan11 (@CAMBUpenn alum, now an Assistant Professor at @swarthmore Biology)! 🧵(1/n) elifesciences.org/articles/9…
Sean Callahan, PhD retweeted
📢 JOB ALERT: Tvardovskiy Lab at @PennEpiInst is hiring at all levels! Interested in chromatin biology, quantitative proteomics, or epigenetic modifications? Learn more about our research and apply at tvardovskiylab.org Please RT
Sean Callahan, PhD retweeted
The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring. @CellReports cell.com/cell-reports/fullte…
Sean Callahan, PhD retweeted
Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutieres Syndrome neuropathology biorxiv.org/cgi/content/shor… #biorxiv_neursci
Sean Callahan, PhD retweeted
Trainee Tuesday!! Join us every Tuesday to meet the rising stars in Neurotrauma research 💫
Introducing Mia Pacheco, an outstanding NNS trainee!
Mia won the Michael Goldberger Award at the 2024 National Neurotrauma Symposium for her impactful contributions to spinal cord injury research. Mia also serves on the NNS Planning Committee, and volunteers with the NNS Local Scholars Program.
Congratulations on your research and thank you for your service to the society! 🏆🧠 @mia_rayne @TAMUNeuro @TAMU_Biology
Sean Callahan, PhD retweeted
Congratulations to @efeierman (@korblab/ @PennNGG) & Katherine Alexander (@berger_lab/ @PennCDB), recipients of the 2024 Kaushal Family Awards in Genetics! A ceremony with presentations by the recipients will take place on 10/25 at 1pm in the CRB Austrian Auditorium @PennGenetics
Sean Callahan, PhD retweeted
Happy Birthday Ben! Today would’ve been his 70th birthday. A renowned scientist who changed the way we see glia cells and the brain and a wonderful friend and advocate, Ben was an inspiration to us all. #neuroscience #glia #advocateforwomeninStem #TransRightsAreHumanRights
Sean Callahan, PhD retweeted
Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system: Immunity cell.com/immunity/fulltext/S…
Sean Callahan, PhD retweeted
It's here! I'm recruiting a #postdoc to work with me on an ANR funded project @institutpasteur! Check it out! We're in @Chrom_Inf & @BCI_Pasteur – at Paris, France
Sean Callahan, PhD retweeted
Biggest medical discoveries of the week (🧵)
1/10
Spinal cord injury triggers activation of T cells, inflammation, and death of neurons
Editing the T cell receptor, using mRNA, suppressed this, and helped recovery from the injury (in mice!)
(Paper: nature.com/articles/s41586-0…)
Sean Callahan, PhD retweeted
Excited to share our recent work on a GBS T7SS LXG toxin @alyx_job @KdoranLab —now out in mBio!🎉
Check out recent work from @KDoranLab @BradySpencer12 @Alyx_Job on T7SS competition in Group B Streptococcus mediated by a secreted LXG toxin. #mBio journals.asm.org/doi/10.1128…
Sean Callahan, PhD retweeted
Excited to announce the launch of the Center for Microbial Medicine @CHOP_Research! This new translational Center of Emphasis at CHOP will be dedicated to finding cures and improving pediatric health through the lens of the microbiome research.chop.edu/cornerston…
So excited to attend my first neuro and glia meeting! Can’t wait to learn all things glia and talk about my work with microglia epigenetics! #CSHLGlia
Welcome to all of our Glia in Health & Disease participants! Make sure to use #cshlglia for all your posts 🦠
A special thank you to the organizers @LiddelowSA @SchaferLabUMass
Looking forward to a great week!
Sean Callahan, PhD retweeted
🎉🌟Andrea Anaya Sanchez @UCBerkeley won a FEBS Letters #PosterPrize at the #GordonResearchConference on #MicrobialToxins & Pathogenicity, recently held in Waterville Valley, New Hampshire, USA!
🏅Congratulations, Andrea! 👏👏👏
@GordonConf
Sean Callahan, PhD retweeted
🏅🌟We congratulate Nestor Ruiz @UTSWMedCenter, on winning a FEBS Letters #PosterPrize at the #GordonResearchConference on #MicrobialToxins & Pathogenicity, recently held in Waterville Valley, New Hampshire, USA! 🎉👏👏👏
@GordonConf @NestorRuiz2411
Sean Callahan, PhD retweeted
interested in knowing what glia cells will be discussed at #CSHLGlia @cshlmeetings next week?
here is a breakdown \\
take homes:
1. astro, oligo, micro make up most of the community
2. we pushed hard to have extra peripheral glia in the oral presentations
3. 5 SLEEPS!
Sean Callahan, PhD retweeted
Unlocking the mind-gut connection: Impact of human microbiome on cognition. Fernández-Real & Co @univgirona examine interactions between gut microbiome & cognition in humans as well as potential means to improve impaired cognition via microbiome changes cell.com/cell-host-microbe/a…
Sean Callahan, PhD retweeted
Our new microglia morphology pipeline tool is officially published in eneuro! eneuro.org/content/11/7/ENEU…

































