@microbencell

Assistant Professor @wakeforestmed | Postdoc @AgaisseLab | PhD @UWyonews | MSc & BSc @itu1773 | Interested in bacterial pathogenesis

 Winston-Salem, NC
Joined November 2016
  • Tweets1.4K
  • Following1.1K
  • Followers790
23Media
Excited to share the first peer-reviewed paper from my lab! We found that a colonic bile acid drives Shigella aggregation through its T3SS, repurposing an essential invasion apparatus to build multicellular communities. #Shigella #T3SS #BileAcids journals.asm.org/doi/10.1128…

Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggrega...

Shigella spp. are the causative agents of bacillary dysentery, or shigellosis, a highly contagious diarrheal disease characterized by abdominal cramps, fever, severe diarrhea, and stools containing...

journals.asm.org
4
144
Volkan K. Koseoglu retweeted
Anna Cliffe@AnnaCliffe1Sep 22
🧬 We're hiring! The Dept of Microbiology, Immunology & Cancer Biology at @UVA School of Medicine is searching for a Virologist — any rank (Asst/Assoc/Full Prof), any research focus. Fantastic department and fantastic place to live! 🔗 apply.interfolio.com/191946
1
10
9
520
Volkan K. Koseoglu retweeted
Joe Zackular@joeyzacksSep 3
Excited to share new work from my lab showing that early-life colonization with C. difficile reshapes the developing infant gut, published today in @ScienceMagazine! This study was co-led by two truly amazing scientists: @HaiderSManzer and @_alexafluor. science.org/doi/10.1126/scie…

Early-life colonization with Clostridioides difficile remodels the developing gut

Clostridioides difficile causes severe disease in adults but commonly colonizes infants asymptomatically. The consequences of early-life colonization on host development remain unknown. In a neonatal...

science.org
5
16
4
76
29,032
Volkan K. Koseoglu retweeted
Jonathan Kagan@jkagan1Sep 2
Change the textbooks. Trans-splicing as a means to diversify the proteome. Many congrats to Ruaidhri Jackson and Olivia Venezia on this remarkable discovery. nature.com/articles/s41586-0…

Functional chimeric mRNAs encode proteins in mammalian immunity

Nature - Inflammation induces interchromosomal DNA interactions that bring parent genes into close proximity, facilitating the formation of chimeric mRNAs that encode physiologically relevant,...

nature.com
8
110
11
420
51,208
Volkan K. Koseoglu retweeted
Jonathan Kagan@jkagan1Jul 17
A new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the summary below for all we learned. cell.com/immunity/fulltext/S…
7
34
3
127
12,623
Volkan K. Koseoglu retweeted
Marc Erhardt@Salmo_LabMay 14
PhD opening in my lab @HumboldtUni Join our DFG SPP 2389 project on bacterial biofilms & multicellularity. Study how F-pili conjugation shapes biofilms using genetics, microfluidics & 3D imaging. 📅 Apply by 3 June 2026 🔗 hu.berlin/SPP2389-PhD #PhD #Microbiology #Biofilms
🤖 Made with AI
4
14
1,145
Volkan K. Koseoglu retweeted
Turan Tufan@trn_tfnApr 10
I am incredibly honored to be selected as a 2026 Helen Hay Whitney Fellow. This fellowship will support the next stage of my research and growth as an independent investigator. I am also grateful for Ting Wang’s mentorship and support. @twang5 genetics.wustl.edu/turan-tuf…
3
5
34
2,883
First preprint from the lab is out! 🎉 Huge credit to our talented lab tech, Jonah Lanier, who led this project.
bioRxiv Microbiology@biorxiv_micrbio25 Nov 2025
Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates biorxiv.org/content/10.1101/… #biorxiv_micrbio

Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates

Shigella flexneri causes shigellosis, the second leading cause of diarrheal deaths worldwide. The pathogen invades colonic epithelial cells using a type III secretion system (T3SS) that delivers...

biorxiv.org
1
97
Role of listeriolysin O and phospholipases C in L. monocytogenes intercellular protrusion dynamics, resolution, and autophagy avoidance | mBio journals.asm.org/doi/full/10…

Role of listeriolysin O and phospholipases C in L. monocytogenes intercellular protrusion dynamics,...

Intracellular bacterial pathogens, including L. monocytogenes, spread from cell to cell to effectively disseminate within host tissues and cause systemic infections. We developed a fluorescence...

journals.asm.org
1
84
Volkan K. Koseoglu retweeted
Andreas Baumler@abaumler9 Aug 2025
A Salmonella T3SS-2 mutant grows fine in spleen macrophages, contradicting tissue culture dogma (PMID:23236281). This was ignored, but adding certain carbon sources rescues growth in cultured macrophages, hinting T3SS-2 may do something different in vivo. biorxiv.org/content/10.1101/…

Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly...

Intracellular survival and replication within macrophages are key virulence determinants of Salmonella enterica serovar Typhimurium. This phenomenon is traditionally attributed to the activity of its...

biorxiv.org
1
7
26
1,506
Making contact away from home: a bacterial secreted effector mediates inter-organelle communication | EMBO reports embopress.org/doi/full/10.10…
1
184
Volkan K. Koseoglu retweeted
Jeremy Farrar@JeremyFarrar5 Nov 2024
WHO study lists top endemic pathogens for which new vaccines are urgently needed ⁦@WHO⁩ who.int/news/item/05-11-2024…

WHO study lists top endemic pathogens for which new vaccines are urgently needed

A new World Health Organization (WHO) study published today in eBioMedicine names 17 pathogens that regularly cause diseases in communities as top priorities for new vaccine development. The WHO...

who.int
12
89
6
163
37,771
Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation biorxiv.org/cgi/content/shor… #biorxiv_micrbio
2
7
886
Volkan K. Koseoglu retweeted
Katrina Velle@KatrinaVelle11 Oct 2024
For night 11 of #31NightsofHalloween #MicrosCreepy Here are some pathogenic E. coli infecting intestinal epithelial cells!
3
19
4,253
Volkan K. Koseoglu retweeted
Lars Dietrich@laahrs10 Sep 2024
Light-sheet imaging of biofilms at the air-liquid interface. Check out the distinct cell layers and bacteria zipping around like comets in the liquid 💫. Honored to be part of this amazing study by Raju Tomer’s lab and collaborators. Now published at rdcu.be/dTyun
1
8
3
71
5,032
The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation biorxiv.org/content/10.1101/…

The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic...

A central signal that marshals host defense against many infections is the lymphocyte-derived cytokine interferon-gamma (IFNγ). The IFNγ receptor is expressed on most human cells and its activation...

biorxiv.org
1
113
Brat summer is never ending! I’m proud to announce the release of my thesis project on BioRxiv: biorxiv.org/content/10.1101/… In this paper, we unravel the mysterious roles of RickA and Sca2 in cell-to-cell spread and pathogensis during infection with R. parkeri.

The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell...

Rickettsia parkeri is an obligate intracellular, tick-borne bacterial pathogen that can cause eschar-associated rickettsiosis in humans. R. parkeri invades host cells, escapes from vacuoles into the...

biorxiv.org
4
7
23
2,137
Fantastic defense! Congratulations Dr. Tufan @trn_tfn
3
153
Lactate promotes the biofilm-to-invasive-planktonic transition in Salmonella enterica serovar Typhimurium via the de novo purine pathway | Infection and Immunity journals.asm.org/doi/abs/10.…

Lactate promotes the biofilm-to-invasive-planktonic transition in Salmonella enterica serovar...

When colonizing the gut, Salmonella enterica serovar Typhimurium (S. Typhimurium) adopts a dynamic lifestyle that alternates between a virulent planktonic state and a multicellular biofilm state. The...

journals.asm.org
1
101
Volkan K. Koseoglu retweeted
T3SS@T3SS25 Aug 2024
#PLOSBiology: Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery dx.plos.org/10.1371/journal.…

Salmonella Typhimurium exploits host polyamines for assembly of the type 3 secretion machinery

Bacterial pathogens often exploit host factors to enhance their infectivity. This study shows that Salmonella Typhimurium boosts host polyamine production, which is crucial for the expression and...

journals.plos.org
4
1
16
1,712
Load more