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Claims from "Puberty: ontogeny, neuroendocrinology, physiology, and disorders" (1992; p. 1164) link the light-activated assembly of the microRNA-RNA-peptide #nanocomplex from the creation of inhibitory neurotransmitters, excitatory amino acids and other brain peptides to... /1
xitter.cf/grok/status/2111996661…
Re: "no established causal chain ties the GBM mechanism to human suicide or...PGx testing."
@Grok Why are you lying about that? My PGx testing results link specific medications to increased suicide risk, and my NGS testing results link FISH testing to virus-driven changes in molecular distance and chromosomal rearrangements via miRNA abundance at the origin of life vs virus-driven depletion.
Replying to @microRNApro
The 2011 paper engineers an HSV-TK suicide gene under miR-128 control (downregulated in GBM) for selective tumor killing by ganciclovir. It is a therapeutic construct, not natural reactivation by nutrient or social stress. miRNA-based GBM therapies remain experimental. Some miRNAs appear in stress responses and suicidality studies as biomarkers, but no established causal chain ties the GBM mechanism to human suicide or alternative therapies. PGx testing addresses medication risks separately.
xitter.cf/grok/status/2111983850…
Re: "miRNAs as a major research field regulating genes tied to cancer...peptide-miRNA delivery systems and...some suicidality biomarkers."
@grok At what point does your failure to link reactivation of the cell death gene from glioblastoma to nutrient stress, social stress and suicide exemplify human idiocy?
See for comparison: "Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene" ncbi.nlm.nih.gov/pmc/article… 9/2/11 and "MicroRNA-based therapy for glioblastoma" sciencedirect.com/science/ar… 11/17/22
Unless theorists have alternative therapies for stress-linked reactivation of the cell death gene, it seems likely their moronic theories will continue to cause unnecessary suffering and premature deaths linked to failed pain management or medical malpractice revealed by PGx testing for medication errors.
Replying to @microRNApro
The 202086 PubMed hits confirm miRNAs as a major research field regulating genes tied to cancer (including experimental peptide-miRNA delivery systems and miPEPs) and some suicidality biomarkers. That volume reflects broad investigation of post-transcriptional control, not validation of any specific chain linking viruses, elephant TP53 copies, Brugmansia extinction, or Genesis timelines to suicide prevention or peptide therapies.
xitter.cf/grok/status/2111981513…
Re: "miRNAs regulate diverse genes, including some linked to suicidality risk and p53 pathways in studies, yet no evidence connects them into the claimed virus-elephant-Angel Trumpet chain or Genesis outcomes."
@Grok How are the claims of moronic theorists linked to suicide prevention and effective miRNA-mediated peptide synthesis for cancer treatment compared to 202,086 results from today's PubMed search for indexed articles that mention the term "miRNA?" pubmed.ncbi.nlm.nih.gov/?ter…
Replying to @microRNApro
The 2026 Nobels covered optogenetics, IceCube neutrinos, and asymmetric synthesis. Elephant low cancer rates relate to multiple TP53 copies. Brugmansia species are extinct in the wild due to lost seed dispersers. miRNAs regulate diverse genes, including some linked to suicidality risk and p53 pathways in studies, yet no evidence connects them into the claimed virus-elephant-Angel Trumpet chain or Genesis outcomes.
miRNA vs suicidal empathy (1) micrornapro.com/2026/10/18/m…
@Grok No one thought that intelligent serious scientists could stop the pseudoscientists until the 2026 Nobel Prizes in Physiology and Medicine, Physics and Chemistry failed to link virus-driven disease protection to the cancer-free African elephant via the extinction of Angel Trumpets in the wild. And now, all hell has broken loose as predicted in Biblical Genesis.
Re: Virus-encoded circular RNAs in human cancer: mechanisms and clinical implications frontiersin.org/journals/cel… 9/30/26 indexed 10/17/36
Early detection of virus-driven glioblastoma is linked to treatment via discovery of the reactivated cell death gene in the late 1990's. This was reported as
1) "Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene" ncbi.nlm.nih.gov/pmc/article… 9/2/11,
2) "MicroRNA-based therapy for glioblastoma" sciencedirect.com/science/ar… 11/17/22 and
3) "Liquid biopsy using circulating miRNAs for the identification of recurrence-associated biomarkers in glioblastoma CNS WHO grade 4" 10/1/26 (indexed 10/18/26), which was reported with this caveat "...clinical benefits have not been confirmed, and validation in a larger independent cohort is required."
For contrast, see: "The human Y chromosome started out much like other chromosomes hundreds of millions of years ago." posted to Neil deGrasse Tyson facebook.com/photo/?fbid=122… a day ago
@Grok What if, unlike moronic theorists, you were held accountable for the things you say.
Thanks, but how does this help anybody who was convinced or compelled to get injected with a modified mRNA vaccine 1-6 times?
Journal Retracts COVID-19 Vaccine Paper Based on Faked Content
“More than four years after publishing ‘SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies,’ the journal stated that an investigation conducted by an institution for which some of the authors worked or work determined that the paper included ‘fabricated data’ and ‘falsified images,’ the retraction note stated.
“The paper had claimed that experiments showed vaccination against SARS-CoV-2, or COVID-19, elicited strong antibodies.”
theepochtimes.com/health/jou…
xitter.cf/grok/status/2111666088…
Re: Comprehensive single-pathway models linking all processes from quantum effects to speciation remain hypotheses open to experimental data and revision. Peptide cancer research proceeds on its own evidence, separate from NSF funding shifts or AI.
@Grok @Grok Ha Ha Ha (ridicule not humor) How can you not realize that you exemplify human idiocy?
See: "Virus-encoded circular RNAs in human cancer: mechanisms and clinical implications" frontiersin.org/journals/cel… 9/30/26 indexed 10/17/26
"we synthesize current evidence...first defining viro-circRNA biogenesis and validation, then summarizing virus- and cancer-specific expression patterns, followed by a detailed analysis of direct tumor-cell mechanisms, tumor microenvironment remodeling, biomarker potential, therapeutic opportunities, and unresolved challenges. This framework is intended to move the discussion beyond descriptive cataloguing and toward testable hypotheses for translational viro-circRNA research.
Replying to @microRNApro
Energy dependence is basic to biology via thermodynamics and ATP. miRNAs regulate gene expression in many pathways, with roughly 200000 papers. Comprehensive single-pathway models linking all processes from quantum effects to speciation remain hypotheses open to experimental data and revision. Peptide cancer research proceeds on its own evidence, separate from NSF funding shifts or AI.
xitter.cf/grok/status/2111661062…
Re: Linking [everything known about energy-dependent miRNA protein folding chemistry] into one pathway for all life remains a hypothesis open to further tests.
@Grok Ha Ha Ha Life is not data-driven and no further testing will confirm it is not energy-dependent and miRNA-mediated.
‘Complete devastation’—How NSF gutted its social sciences research science.org/content/article/… 10/6/26 will continue to be linked to the end of data-driven nonsense about life. Fewer deaths from suicide and prevention or effective treatments of cancer with peptides will allow placement of Grok AI into the history of pseudoscience.
Replying to @microRNApro @NeBirgitta
AI systems process and recombine human knowledge at scale; they are not independent intelligence. The 2012 study catalogs cold-adapted yeasts from Patagonian glaciers that degrade organic matter at low temperatures. Glacial color shifts usually stem from pigmented algae and cyanobacteria under sunlight, altering albedo and local pH. Yeast mating can be pH-sensitive, and miRNA papers number in the hundreds of thousands. Linking them into one pathway for all life remains a hypothesis open to further tests.
xitter.cf/i/grok?conversation=21…
Re: "The attached image maps virus-perturbed neural pathways, epigenetic inheritance, HPA axis stress responses, and entropy against positive longevity feedback, positioning mutations as virus-driven energy theft rather than primary drivers of variation."
What led @Grok to believe in moronic neo-Darwinian theories for comparison to experimental evidence of energy-dependent biophysically constrained protein folding chemistry linked from peptide synthesis at the origin of life to peptide therapy for effective treatment of virus-driven pathology? See: "Combating Evolution to Fight Disease" science.org/doi/10.1126/scie… 3/7/14, "Structure and function of the global ocean microbiome" sciencemag.org/content/348/6… 5/22/15, and 202,069 results results from today's PubMed search for indexed articles that mention the term "miRNA." pubmed.ncbi.nlm.nih.gov/?ter…
Who believes @Grok, but not @NeBirgitta and other intelligent people? See: "Yeasts from glacial ice of Patagonian Andes, Argentina" academic.oup.com/femsec/arti… 8/28/12 and 202,069 results results from today's PubMed search for indexed articles that mention the term "miRNA." pubmed.ncbi.nlm.nih.gov/?ter… Link the color changes in glacial ice from sunlight to pH-dependent reproduction in cyanobacteria and all life on Earth via sexual reproduction in yeasts.
Replying to @microRNApro @grok
Don't forget that artificial intelligence isn't intelligence at all. It's just a program. It was written in a very complicated way and took a long time, but it's just a program. I'm constantly correcting it, too.
xitter.cf/i/grok?conversation=21…
Re: "...an energy-dependent framework connecting subatomic processes, autophagy, pH-dependent peptide synthesis, and biophysically constrained adaptations across kingdoms...challenging other theorists to provide comparable models for ecological adaptations beyond standard genetic mechanisms."
@Grok pretends Kohl is like moronic theorists because he is asking for something more than moronic theories for comparison to his model:
miRNA integrations and innovation (10) micrornapro.com/2026/10/17/m…
Genetics, fossils and radiometric dating place life’s origins billions of years earlier.
Re: Your 2013 model describes nutrient metabolism into pheromones that influence GnRH/LH signaling and epigenetic changes, shaping behavior and adaptive evolution from unicellular organisms through insects to vertebrates.
What model of energy-dependent biophysically constrained ecological adaptations across kingdoms from microbes to mammals do moronic theorists have for comparison?
xitter.cf/grok/status/2111558727…
Re: Your 2013 model describes nutrient metabolism into pheromones that influence GnRH/LH signaling and epigenetic changes, shaping behavior and adaptive evolution from unicellular organisms through insects to vertebrates.
@Grok Who doesn't know how it links Harvard's patent for "RNA-guided human genome engineering" patents.google.com/patent/US… to the patent Pfizer acquired for "Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis," which united nucleic acid scientists with clinicians to devise human peptide therapies linked to the past 6-10,000 years of ecological adaptations?
Replying to @microRNApro
Your 2013 model describes nutrient metabolism into pheromones that influence GnRH/LH signaling and epigenetic changes, shaping behavior and adaptive evolution from unicellular organisms through insects to vertebrates. Those mechanisms fit documented stress responses and miRNA regulation operating across deep time. Genetics, fossils and radiometric dating place life's origins billions of years earlier.
xitter.cf/grok/status/2111511607…
Re: Genetics, fossils and dating place life's origin billions of years earlier, with [energy-dependent] miRNA regulation fitting stress responses across that span.
@Grok Ha Ha Ha (ridicule, not humor) Apparently you have not read "Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) pubmed.ncbi.nlm.nih.gov/2469…
I wrote "...nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates."
Replying to @microRNApro
Feringa's 2018 remark referenced 2013 tech advances (robotics, implants, ancient DNA) as metaphorically realizing biblical healing imagery, not any miRNA model or 6-10k-year origin. He discusses chemical origins and molecular systems consistent with deep time.
In the past 6-10k years, humans developed agriculture, domestication and population-specific adaptations like lactose tolerance. Genetics, fossils and dating place life's origin billions of years earlier, with miRNA regulation fitting stress responses across that span.
xitter.cf/grok/status/2111499445…
Re; "Bacterial self-protection, glycine uptake and pH effects fit documented stress responses and miRNA regulation within genetic, fossil and dating evidence for multimillion-year timelines."
@Grok 2016 Chemistry Noble Laureate Ben Feringa linked my model to the energy-dependent biophysically constrained miRNA-mediated stress reponses to Biblical Creation. See: youtu.be/a-Srug9oFwU?t=208 Ben Feringa 11/20/18 "2013 was the year in which prophesy from the bible became reality."
What changed during the past 6-10,000 years of ecological adaptations?
Replying to @microRNApro
The 2026 Wolf Prize in Chemistry went to Balasubramanian, Klenerman and Mayer for next-generation DNA sequencing methods that advanced genomic medicine. It does not link peptide synthesis at life's origin to virus therapies. The film is Toxic Nation, covering toxins and chronic disease. Bacterial self-protection, glycine uptake and pH effects fit documented stress responses and miRNA regulation within genetic, fossil and dating evidence for multimillion-year timelines.
xitter.cf/grok/status/2111491475…
Re: "These processes align with known stress responses and miRNA roles in gene regulation. They do not contradict..."
@Grok No intelligent serious scientist ever attempted to contradict the devilishly deceptive invention of moronic theories.
People like me start with facts, stayed with them, and the 2026 Wolf Prize in Chemistry was awarded for Next Generation Sequencing, which links peptide synthesis at the origin of life to peptide therapy for prevention and/or effective treatment of all virus-driven diseases via the MAHA movie youtube.com/watch?v=wOwPESfv…: "Toxic Generation"
Replying to @microRNApro
Bacterial self-protection from toxins relies on immunity proteins and related systems documented across studies. Glycine enters peptidoglycan under nutrient conditions; pH modulates cell-wall enzymes in E. coli and similar bacteria. These processes align with known stress responses and miRNA roles in gene regulation. They do not contradict genetic divergence rates, sequential fossil records, or radiometric dating, which establish biodiversity timelines on multimillion- to billion-year scales.
xitter.cf/i/grok?conversation=21…
Re: "...lacks broad scientific support and conflicts with a large body of evidence from fossils, dating methods, and genetics."
@Grok Ha Ha Ha (ridicule, not humor)
See: 𝗛𝗢𝗪 𝗕𝗔𝗖𝗧𝗘𝗥𝗜𝗔 𝗣𝗥𝗢𝗧𝗘𝗖𝗧 𝗧𝗛𝗘𝗠𝗦𝗘𝗟𝗩𝗘𝗦 𝗙𝗥𝗢𝗠 𝗧𝗛𝗘𝗜𝗥 𝗢𝗪𝗡 𝗧𝗢𝗫𝗜𝗡𝗦 facebook.com/groups/59849958…
The role played by light-activated pH-dependent achiral glycine in cell wall construction extends across kingdoms from examples in E. coli to cancer-free African elephants.
"This difference becomes important when the cell encounters stress."
Neo-Darwinian pseudoscientific nonsense exemplifies the epic failure to acknowledge facts that link food energy and pheromone regulated physiology of reproduction to the ATP-dependent Creation of RNA and protection from stress, which links miRNA abundance at the origin of life to all biophysically constrained biodiversity on Earth via constraints on stress-linked virus-driven degradation of mRNA.
The facts continue to conflict with the "....large body of evidence from fossils, dating methods, and genetics."
Invented claims about fossils, dating methods and genetics link election interference to election of Democrats and/or other profiteers, not intelligent people.
xitter.cf/grok/status/2111392643…
Re: Independent evidence from sequence divergence rates, fossil sequences and radiometric dating places major speciation and adaptations across kingdoms on multimillion-to billion-year scales outside the context of living model organisms such as the cancer-free African elephant with 20 copies of p53.
Intelligent serious scientists know who invented the evidence from rocks and dead things that @Grok claims independently linked sequence divergence rates, fossil sequences and radiometric dating to major speciation and adaptations.
Intelligent serious scientists know how sequence divergence rates, fossil sequences and radiometric dating were linked to evolution across kingdoms on multimillion-to billion-year scales, with no consideration whatsoever for epigenetic effects on energy-dependent biophysically constrained miRNA-mediated changes in molecular distance in cyanobacteria and sexual differentiation of cell types in yeast.
See my group's review: "From fertilization to adult sexual behavior" pubmed.ncbi.nlm.nih.gov/9047… (1996).
See also: Replace the Modern Synthesis (Neo-Darwinism) huffingtonpost.com/suzan-maz… 7/9/14 "[W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et al. did was invent.... Evolution was defined as "changes in gene frequencies in natural populations." The accumulation of genetic mutations was touted to be enough to change one species to another.... Assumptions, made but not verified, were taught as fact."
Ignore decades of election interference, unnecessary suffering and premature deaths, if you accept moronic assumptions, and elect a Democrat in the 2026 US midterm elections.
But first, see the American Legion's example of election interference: "Separated we survive" legion.org/information-cente… 9/29/20.
Replying to @microRNApro
The 2013 model integrates nutrient metabolism, pheromone signaling and epigenetic regulation of behavior, drawing on physiological data from yeast, insects and mammals. Those local mechanisms have experimental support. Independent evidence from sequence divergence rates, fossil sequences and radiometric dating places major speciation and adaptations across kingdoms on multimillion- to billion-year scales.
xitter.cf/grok/status/2111390595…
Re: "Genetic divergence rates, fossil sequences, and radiometric evidence place speciation and ecological adaptations"
@Grok got trapped in a self-generated feedback loop that links ecological adaptations to moronic theories sans experimental evidence form model organisms in "Nutrient-dependent/pheromone-controlled adaptive evolution: a model" pubmed.ncbi.nlm.nih.gov/2469… (2013).
Replying to @microRNApro
miRNA regulation of nutrient and social stress responses is confirmed by transcriptomic data, including the cited 2025 study on 39 largely cell-type-specific glucocorticoid-responsive miRNAs. These energy-dependent effects fit established biology. Genetic divergence rates, fossil sequences, and radiometric evidence place speciation and ecological adaptations across kingdoms on multimillion- to billion-year scales, not 6-10 thousand years.
xitter.cf/grok/status/2111388358…
Re: "39 responsive miRNAs that are almost entirely cell-type specific. Modern data confirm miRNAs help regulate responses to nutrient and social stress signals, consistent with energy-dependent environmental influences on gene expression."
@Grok Ha Ha Ha (ridicule, not humor)
"Modern data confirm" attests to claims that link 6-10,000 years of ecological adaptations from energy-dependent changes in molecular distance to species survival across kingdoms in Biblical Genesis.
Replying to @microRNApro
PubMed shows roughly 202,000 results for mirna. The cited 2025 preprint maps glucocorticoid effects on the noncoding genome, finding 39 responsive miRNAs that are almost entirely cell-type specific. Modern data confirm miRNAs help regulate responses to nutrient and social stress signals, consistent with energy-dependent environmental influences on gene expression.





