Biosatistician and Health Researcher at @MiKTMC @umichmedicine
Joined January 2019
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Margaret Helmuth retweeted
For patients with the rare kidney condition FSGS without nephrotic syndrome, treatment options have been limited. A new approval offers hope. fda.gov/drugs/drug-alerts-an…
Margaret Helmuth retweeted
🎉🎉🎉Historic day for the #FSGS community— the FDA has fully approved Sparsentan as the first drug for patients with FSGS!! And in addition to adults, it’s approved for children ages 8 and over too 🙌
Special shout out to the #PARASOL ☂️ project that played a pivotal role in defining endpoints for FSGS trials!
So proud to be a part of this amazing community (& former investigator for the DUPLEX trial). And grateful my patients now have a therapy to treat a devastating kidney disease 🙏🏼 @ISGDtweets @nephcure @LauraMarianiMD @ASmith_Stats @mehelmuth @KretzlerM @rheault_m @kirkcampbell
streetinsider.com/Business+W…
I am so proud of this community and proud to be a part of this historic moment ❤️
More than 100 years after #FSGS was first described, we have the first FDA-approved treatment. A proud day for the collaborative #ParasolProject led by ISGD, @nephcure, @KidneyHealthIn and @nkf! This is what happens when the global community unites to transform glomerular health, and it's only the beginning. ⛱️ eu1.hubs.ly/H0tsdJ_0
@LauraMarianiMD @KretzlerM @Tobias_B_Huber @ASmith_Stats @mehelmuth @MiKTMC
Margaret Helmuth retweeted
PARASOL biostats leads Abigail Smith and @mehelmuth gave a guest lecture in @HamiltonCollege BIO 202: Biostatistics class - Nice examples to learn about statistical methods & considerations in longitudinal studies and clinical trials & highlight real life impact of biostats work
This is huge! I'm so proud to have been a part of making this happen!!!
✅ Major milestone: FDA confirms proteinuria as an acceptable primary endpoint for full marketing approval of DMX-200 in the US.
A significant step forward for Dimerix and #FSGS patients.
Learn more: bit.ly/4lQS56k
I'm proud to be a part of this work and team! @ASmith_Stats @LauraMarianiMD ajkd.org/content/mostread
Association of #COVID19 vs COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease
bit.ly/452z7jx (FREE temporarily)
@mehelmuth @asbomback @IqtidarMyda @KatherineTuttl8 @RBouMatarMD @Larrypedkid @brurobinson1 @rheault_m @CureGn
Margaret Helmuth retweeted
A small subgroup of the PARASOL team celebrating with our well-traveled banner
Margaret Helmuth retweeted
PARASOL biostats all-stars Abigail Smith and @mehelmuth with the poster! #KidneyWk
Margaret Helmuth retweeted
A little stroll post-PARASOL workshop took us to the place where the magic happens @NIH @Moinsaleem @Tobias_B_Huber @DannyGale_1
Margaret Helmuth retweeted
The fantastic @LauraMarianiMD revealing data-derived trial endpoint proposals to allow feasible clinical trials in #FSGS #ParasolProject @ISGDtweets
Margaret Helmuth retweeted
Excited to announce our recent paper "Natural History and Clinicopathological Associations of TRPC6-Associated Podocytopathy" appearing today as pre-print in @JASN_News
A great collaboration across the world to put together 64 cases for 39 families segregating TRPC6 missense variants and describe their course of disease and clinicopatological features!
#FSGS #RareDisease #HumanGenetics #TRPC6 #rFSGS #nephroticsyndrome
@GlomCon @ISGDtweets @GbadegesinLab @TheSampsonLab @actiobiosci @CUIMCGlomCenter @asbomback @Martinelli_Elen @ASNKidney @the_asci @tzeyinlim @JMartinoActual @SlavePetrovski @AstraZeneca @mehelmuth @kidneyomicsamps @KretzlerM @CureGn @Moinsaleem @nephcure @ASPNeph @NephroticSyn @NephroticF @ESPNSociety @IPNA_PedNeph @thePNRC @AmerAcadPeds @rFSGSInitiative
journals.lww.com/jasn/abstra…
Margaret Helmuth retweeted
Increased risk of kidney failure in patients with genetic kidney disorders @CureGN pubmed.ncbi.nlm.nih.gov/3922…
Margaret Helmuth retweeted
Thank you for reporting!
More to come on this, stay tuned :)
#APOL1 #FSGS
@GbadegesinLab @kidneyomicsamps @TheSampsonLab @OpeyemiOlabisi8 @H3Africa @goKDIGO @PrAniang @CUIMCGlomCenter @ApolloNetwork13 @GuptaYask @ilori_titi @AfricanAFRAN @dhekidney @NephJC @MegSise @mehelmuth @CureGn @kirkcampbell @GlomCon @LauraMarianiMD
"Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease"
nature.com/articles/s41467-0…
Margaret Helmuth retweeted
Racial & Ethnic Disparities in Acute Care Utilization Among Patients with Glomerular Disease
bit.ly/3rnjkKR (FREE temporarily)
@JKrissberg @MichelleOShaug3 @mehelmuth @SalemAlmaani @KayeBrathwaite @DoreyGlenn @CureGn
Margaret Helmuth retweeted
Just out. Proud to work with these folks from @UMichKidney , @UNCKidney @nationwidekids and @CureGn and @nephcure
“Elevated Exposure To Air Pollutants Accelerates Primary Glomerular Disease Progression”
kireports.org/article/S2468-…
Margaret Helmuth retweeted
"Predicting Patient Response to Standard-of-care Therapies in Glomerular Diseases" by @mehelmuth @LauraMarianiMD, et al, is presented at WCN'24 in Buenos Aires. Their work was transformed into a visual abstract by #ISNWCN Social Media Team member @goldenglom
Margaret Helmuth retweeted
ISGD reunión during the WCN’24:
✅ Members from around the 🌎
✅ GN in ten
✅ Parasol project
✅ Defining MCD and idiopathic nephrotic syndrome
✅ Hot topics in GN session webinar May 10 2024
Margaret Helmuth retweeted
😊Thank you to everyone who came to this morning's breakfast! Wonderful to meet so many members in person and especially to connect w/ the outstanding neph community here in Argentina and Latin America. We're looking forward to future collaborations! 🎉
-Laurel and Tobias
Margaret Helmuth retweeted
⛱️ You can now access a replay of last week's webinar about the PARASOL Project: eu1.hubs.ly/H08dVm80 @nephcure @nkf @ASNKidney @MiKTMC