@mcstitzer

Interested in transposable elements. NSF postdoc at Cornell. @PopBioUCD alum. she/her.

mcstitzer.github.io/
Joined September 2014
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The maize genome is bursting with TEs, jumping genes that can move to new positions - but do TEs matter for maize fitness?
bioRxiv@biorxivpreprint19 Sep 2023
Transposable element abundance subtly contributes to lower fitness in maize biorxiv.org/cgi/content/shor… #bioRxiv
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Fun to bring along current (@MerKhaiBurch, Arcadio) and former (Asher, @baoxing_song, @GuillRamstein) labmates into the world of TEs, their help on quantitative genetics and genomics was a*maiz*ing, as well as @CedricFeschotte and @EdBuckler for all their support
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Let us know what you think! We're excited about further characterizing the evolutionary forces that interact to give rise to the highly polymorphic, absolutely beautiful TE landscape of the maize genome🌽
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Really excited about AnchorWave! @baoxing_song taught me so much about alignment, and put together an approach that works for the real life messy stuff about genomes - like lots of TEs and paleopolyploidy
Baoxing Song@baoxing_song22 Dec 2021
Our genome alignment tool - AnchorWave has published online at: pnas.org/content/119/1/e2113… It has a big improvement for plant genome comparison.

AnchorWave: Sensitive alignment of genomes with high sequence diversity, extensive structural...

Millions of species are currently being sequenced, and their genomes are being compared. Many of them have more complex genomes than model systems ...

pnas.org
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It works by finding conserved gene anchors between assemblies, then uses an implementation of the wavefront algorithm that allows for two gap penalties to perform a global alignment of each anchor and interanchor region
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We've tested it out on lots of plant species (and even a goldfish!) and recover not only large scale structural variation, but also base pair resolution of conserved regulatory sequence, and gapped alignment across TE-rich regions
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Michelle Stitzer retweeted
PLOS Genetics@PLOSGenetics18 Dec 2021
Transposable elements (TEs) are #DNA pieces that move around the #genome Stitzer et al model the roles of TEs & reveal a diversity of survival strategies of TE families in the #maize genome 🔎: doi.org/10.1371/journal.pgen… @mcstitzer @sna8 @SpringerNathan @jrossibarra
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It’s out! A natural history of the MANY transposable elements found in the maize genome journals.plos.org/plosgeneti…

The genomic ecosystem of transposable elements in maize

Author summary Transposable elements (TEs) are pieces of DNA that can jump to new positions in the genome. When they land at a new location, they generate a mutation. Such mutations in genes affect...

journals.plos.org
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So absolutely honored! Thanks to @PopBioUCD and the whole evolution and ecology community at UC Davis
Graham Coop@Graham_Coop7 Apr 2020
Congratulating to Michelle Stitzer (@mcstitzer) this year's winner of the @ucdavis Outstanding Dissertation in Ecology and Evolution Merton Love Award. She'll give her seminar "The Genomic Ecosystem of Transposable Elements in Maize." on May 28th.
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The maize genome is an ecosystem, full of transposable elements! With @sna8 @SpringerNathan and @jrossibarra biorxiv.org/content/10.1101/…
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Replying to @jrossibarra @sna8 @mcstitzer @abrohamm1 @SpringerNathan @HirschCandice
In only four maize genomes we find 100's of thousands of variable TEs, more than an order of magnitude more TEs that vary among lines than were found in 3,000 rice lines! That's about 1.5Gb of variable TE DNA in FOUR HAPLOID GENOMES. 2/6
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Happy birthday Darwin! 210 never looked so delicious. #cookiedarwin @PopBioUCD #butterfest
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Had such a great time at #UppTransposon2018 and so excited to now have the complete Mobile DNA trilogy on my shelf! Thanks again to organizers Patric Jern, @ClaudiaKutter, and @alexander_suh.
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Michelle Stitzer retweeted
New Phytologist@NewPhyt24 Sep 2018
Maize domestication and gene interaction @mcstitzer @jrossibarra #Tansleyreview ow.ly/N3Vp30lUOU3
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Nice @ucdavis news piece on my work on transposable elements in maize. ucdavis.edu/news/tracking-do…
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