@maxbsosa

JSPS Postdoctoral Fellow with Ikuro Abe | @MChangGroup + UC Berkeley alum | biosynthesis

 Tokyo-to, Japan
Joined October 2018
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Proud to share my first author publication from my PhD work in @ACSPublications ! Vitamin B2 is essential for the survival of all organisms. We show how bacteria can completely break down this important molecule. If you love vitamins, this is a must read! tinyurl.com/2tw6jjw8

Vitamin B2 Catabolism: Nature’s Route from Riboflavin to Acetoacetate and Pyruvate

Abstract. Here we report the cloning and complete in vitro reconstitution of the enzymes of the riboflavin catabolic pathway. The pathway begins with the o

pubs.acs.org
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New research in Science represents a notable step forward in designing enzymes from scratch. With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. Learn more: scim.ag/4hU7O1H
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Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide Expands the Mechanistic Competence of Diiron Oxidases by @sanjoyadak90, Logan Calderone, @august_krueger, Maria-Eirini Pandelia, @BradMoore_SIO @moorelabsio @Scripps_Ocean in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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JNP誌に第一著者のレビューが掲載されました!天然物の特殊アミノ酸生合成に関わるPLP依存置換反応をまとめました。pubs.acs.org/doi/full/10.102…

Pyridoxal 5′-Phosphate (PLP)-Dependent β- and γ‑Substitution Reactions Forming Nonproteinogenic...

Abstract. Living organisms synthesize various nonproteinogenic amino acids (NPAAs) as the building blocks of natural products. These NPAAs are often biosyn

pubs.acs.org
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I'm finally on my way! After a long, relaxing summer, I'm finally headed to Tokyo as a @jsps_sns Postdoctoral Fellowship. I'll spend the next few years working with Prof. Abe and the many talented scientists @UTokyo_News Lab of Natural Products Chemistry.
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I'm very grateful to my PhD advisor @MChangGroup and a long-time mentor @hanzyduzit for their support in helping me get here! Of course, I'm grateful to Prof. Abe for taking this chance on me.
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I'm ready to get back in the lab and continue to discover some interesting things about natural products and biosynthesis, as well as enjoy my new Tokyo life! 🧫🧬🧪👨🏻‍🔬🗼🏙️🗻
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My PhD work studying the biosynthesis of medicinal natural products in plants is now published. Check it out!
Cell@CellCellPress14 Sep 2024
Now online! A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes dlvr.it/TDDhQ3

A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes

The biosynthetic pathways in plants that yield important and clinically relevant toxins are complicated and difficult to elucidate. Through combined metabolomics, the biosynthetic pathways of a...

cell.com
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We should make "Very GMO" plant snacks. Like, bespoke, artisanal GMO. Limited edition glowing apples etc. Tie dye banana chips. Kombucha with yfp served in uv lit bottles.
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Very happy to share the final chapter of my postdoc time in the Abe group @UTokyo_News . Wondering how a PLP-dependent enzyme utilizes NAD and SAM as substrates for a (3+2)cycloaddition to construct azaindane natural products? nature.com/articles/s41929-0…

The structural basis of pyridoxal-5′-phosphate-dependent β-NAD-alkylating enzymes

Nature Catalysis - Recently, the pyridoxal-5′-phosphate-dependent enzyme SbzP was reported to catalyse a [3+2]-annulation reaction yielding β-NAD-derived antibiotics. Now, cryo-electron...

nature.com
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Unique highly hetero-substituted benzenes are defence compounds from tiny springtails. The minute amounts available needed the combination of GC/MS, GC/IR, DFT-calculation, and synthesis to arrive at the structures. Chem. Sci. doi.org/10.1039/D4SC03182B
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A Manic Monday? We are excited to bring you the first PLP enzyme catalyzing intermolecular Mannich reaction @J_A_C_S pubs.acs.org/doi/10.1021/jac… This work is led by the amazing postdoc @shaonan_liu and supported by @ACSGCI

Enzymatic Synthesis of Unprotected α,β-Diamino Acids via Direct Asymmetric Mannich Reactions

Abstract. α,β-Diamino acids are important structural motifs and building blocks for numerous bioactive natural products, peptidomimetics, and pharmaceutica

pubs.acs.org
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Interesting how unrelated Fe-S clusters with different cluster geometries both facilitate LA-catalyzed DA reaction in biosynthesis. Would be cool to see how various ferredoxins fare against panels of inter/intramolecular DA substrates nature.com/articles/s41467-0…

Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis

Nature Communications - Native enzymes using Lewis acid catalysis in intramolecular [4+2] cycloaddition remain unreported. Herein, the authors report the ferredoxins catalyzed [4+2] cycloaddition...

nature.com
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Check out our review on the current state of biocatalysis. Congrats to the authors. nature.com/articles/s41586-0…

Expanding chemistry through in vitro and in vivo biocatalysis

Nature - This Review considers developments in enzymes, biosynthetic pathways and cellular engineering that enable their use in catalysis for new chemistry and beyond.

nature.com
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What an unexpected strategy for making enediyne scaffolds!
Shen Lab@lab_shen3 Jun 2024
We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio nature.com/articles/s41589-0…
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Big congratulations to our newly minted doctors, Dr. Max Sosa (@maxbsosa), Dr. Elijah Kissman, and Dr. Douglas Millar (@_PhDoug ).
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We got the published version out! During review, we re-examined our stereochemical assignment of absolute configuration. Thanks to @biotools we were able to use vibrational circular dichroism to confidently assign the abs. config. of pazamide :)
MChangGroup@MChangGroup23 Mar 2024
Check out the published version in @angew_chem! onlinelibrary.wiley.com/doi/…

Biosynthesis of Strained Amino Acids by a PLP‐Dependent Enzyme through Cryptic Halogenation

Halogenases enable organisms to alter the reactivity of a biological substrate by enzymatically installing a leaving group. In this communication, we discover a bacterial gene cluster which uses a...

onlinelibrary.wiley.com
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And we began thinking about how these metabolites *could* facilitate plant-bacteria interactions! Much work is needed to make definitive claims, but I'm glad we could take even a small stab at the "raison d'etre" of this biochemical pathway, a too-often overlooked question
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Anyways, biology has so many unusual phenotypes and my favorite are chemical! Discovering interesting (bio)chemical phenotypes and how they interact with the world around them hopefully will lead me to long, exciting, and engaging career.
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