MD-PhD candidate @uoftmdphd | Researching childhood cancers | Genomics, Writing & Donut enthusiast | Learning and Unlearning
Scarborough, Ontario
Joined October 2020
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4yrs ago,@rmkhokha asked me to study the #metabolism of normal mammary epithelial cells for my MSc. Today, I share with you my 1st first-author pub in @NatMetabolism (tinyurl.com/emnk5tw).Below a thread on how studying normal cells helps us better understand #breastcancer. /1
In 2021, I tagged @KarlDeisseroth in a tweet about his book. To my surprise, he replied and we held 2 writing workshops
Despite being so busy, Karl has gone out of his way to be an incredible mentor for physician-scientist trainees!
Congrats on the well-deserved Nobel!
Mathepan Mahendralingam retweeted
Thanks to everyone sharing in this moment!
I’m so grateful to my trainees & collaborators…
dlab.stanford.edu/group-memb…
(pic: optogenetics conference chairs, Tuscany)
Reading for all those asking:
for technical details: dlab.stanford.edu
for everyone: deisseroth.org/projections
Mathepan Mahendralingam retweeted
Congratulations to our first #NobelPrize laureate of 2026 🎉
Early this morning Karl Deisseroth found out he was awarded this year's Nobel Prize in Physiology or Medicine.
He seems very happy with the news!
ALT Karl Deisseroth on the phone looking happy
Mathepan Mahendralingam retweeted
BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
Mathepan Mahendralingam retweeted
Transcription Factors are central to cellular identity and function. The human genome currently contains ~1600 of them. But could there be productive human transcription factors that have not evolved? Out today in Cell, a tremendously talented graduate student Oliver Takacsi-Nagy @Oli_TN, together with the @Satpathology Lab, determined to find out. (1/10)
authors.elsevier.com/sd/arti…
Mathepan Mahendralingam retweeted
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote
1/n
Check out the amazing paper by Mehdi! The genomes of relapsed pediatric cancers are shaped by the cancer therapy that was once used to eradicate them!
Watching the story unfold over the years has been a honour!
Our paper out today in @Nature:
How does prior therapy shape childhood cancer at the genomic level? 🧬
nature.com/articles/s41586-0…
rdcu.be/fvdNz
#Nature #CancerGenomics #MutationalSignatures #PrecisionMedicine #PediatricCancer #Resistance
Mathepan Mahendralingam retweeted
Our paper out today in @Nature:
How does prior therapy shape childhood cancer at the genomic level? 🧬
nature.com/articles/s41586-0…
rdcu.be/fvdNz
#Nature #CancerGenomics #MutationalSignatures #PrecisionMedicine #PediatricCancer #Resistance
Mathepan Mahendralingam retweeted
Nature research paper: Prior therapy defines mutation profiles in childhood cancer at relapse
go.nature.com/3Rw3fDd
Mathepan Mahendralingam retweeted
Mutagenic effects of chemotherapy on relapsed childhood tumours cataloguing each major drug’s associated mutational signatures & how this shapes disease at relapse or metastasis @Nature @mlayeghi @SickKidsNews 🇨🇦
nature.com/articles/s41586-0…
Mathepan Mahendralingam retweeted
WEMBY JUST DROPPED A BAR:
"The lack of experience is a strength of us...because we could do impossible stuff because we don't know it's impossible" 🥶
(h/t @ohnohedidnt24)
Mathepan Mahendralingam retweeted
Thank you @KarlDeisseroth! Getting a glimpse into your thinking process and philosophy behind your writing was very inspiring. It encourages us to work with vigour, treat with humanity, and reflectively express ourselves.
5yrs later, our 2nd @uoftmdphd bookclub ft @KarlDeisseroth! @kao_jenn and I asked KD how to write for papers and for prose. We revisited Projections and students shared their writing. Thank you Karl for your mentorship of physician-scientists & reminding us of the power of words
Today’s talk hosted @uoftmdphd and moderated by @mathepan and I, once again proved @KarlDeisseroth as a pioneer - this time, in bridging the gap between basic science, psychiatry, and literature. (1/4)
Mathepan Mahendralingam retweeted
What protects some people from leukemia?
Thrilled to share work from the @bloodgenes lab, now published in @Science.
We identify an inherited genetic variant that protects stem cells from blood cancers by reducing risk of CHIP.
science.org/doi/10.1126/scie…
🧵👇 (1/n)
Delighted to have our work on 🧬 resilience to 🩸cancer led by @GauravA_UK & amazing collaborators, including @KharasLab, published in @ScienceMagazine: science.org/doi/10.1126/scie… 🧵
Mathepan Mahendralingam retweeted
How did the devastation of the atomic bombings 80 years ago ultimately help give rise to bone marrow transplantation and modern #stemcell biology? Our historical commentary with @JGudera in @NatureCellBio explores these unappreciated connections: nature.com/articles/s41556-0…
Mathepan Mahendralingam retweeted
This went live today, on Thanksgiving, which feels quietly special.
This article is about one of my favorite topics: how human genetics is being used to shape drug development. It’s a synthesis of ideas and lessons that have emerged over many years, brought together into a single narrative.
I’m grateful for the opportunity to give structure to these thoughts — and excited about where human genetics–driven drug development is headed next. The future here feels genuinely promising.
Many thanks to the editors at @WorksInProgMag — @bswud and @salonium — for the opportunity and for helping edit this article into its best possible version.
Hope you enjoy this light read on Thanksgiving Day :)
🧬 Nature’s laboratory
worksinprogress.co/issue/nat…
Mathepan Mahendralingam retweeted
The separation of immunodeficiency and rheumatology is a relic of history in modern medicine. It is all immunology in the end - Excellent new reminder by Megan Cooper & Joshua Tobin @jhumimmunity rupress.org/jhi/article/1/3/…
After years of trying to convince Maaz not to drop out of the MD/PhD program, I’ve accepted that math is his singular passion
All the best at @AnthropicAI ! Claude Maaz 5.1 coming soon to a browser near you 👀🖥️
Wild that the same autoantibodies to IFN-I found in life-threatening COVID-19...might actually improve response to checkpoint immunotherapy 🤯
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too?
That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below
nature.com/articles/s41586-0…
