Massimaux

Among pre-exposure, when you take it to prevent contagion, or post-exposure, when you take it after having contact with an infected person to try to avoid the disease, there are 18 studies. ~@filipe_rafaeli What Would a Brutally Honest Man Look Like? brownstone.org/articles/what…

RCT 923 adults in the USA showing 38% lower COVID-19 risk with 4,000 IU/day vitamin D compared with 400 IU/day, aHR 0.62, p=0.045, logrank p=0.029. They study tested 400, 4,000, and 10,000 IU. A priori 4,000 is expected to be most effective of the doses tested. 400 IU is below the RDA and only raises levels by ~5 ng/mL. The IOM/National Academies UL for adults is 4,000 IU/day which produces levels in the 40-50 ng/mL range without a hypercalcemia signal. 10,000 IU is 2.5x the UL, and several mechanisms predict worse results with excessive dosage. No benefit was seen for 10,000 IU, and the pooled arms lose significance (aHR 0.73, p=0.1). c19early.org/meltzer3.html There are now 138 treatment studies, 41 RCTs, and very high confidence in efficacy with meta-analysis, p < 0.000001. Results across studies match the biological mechanisms: efficacy gradient across outcomes (p = 0.03), calcitriol/calcifediol vs. cholecalciferol (p = 0.03), continuous vs. bolus treatment (p = 0.00004), and acute treatment vs. chronic prophylaxis (p = 0.004). This is not possible without a real treatment effect. c19early.org/dmeta.html NIH claims there is "insufficient evidence" but they reference only 5 of the 138 studies, with no updates since 2023. ncbi.nlm.nih.gov/books/NBK57… There was no real-time proactive analysis of COVID-19 treatment research, which guarantees delayed recognition of efficacy or harm. By that time, moral, legal, career, and reputational liabilities strongly disincentivize any admission of error. If authorities ever get around to analyzing the studies, there will be a strong disincentive for reporting efficacy. ❤️‍🩹 A key reform, applicable to current and future diseases, is for authorities to implement real-time proactive analysis of clinical evidence.

There was a study that conducted a head-to-head comparison of remdesivir and ivermectin showing that ivermectin had 69% lower mortality than remdesivir. Authors used propensity score matching and adjustment for potential confounders and yet self-retracted it. Self-censorship.

In mid-2021, as Israel expanded vaccine eligibility to adolescents and the campaign was in full force, nearly 295,000 adverse event reports remained buried in the national surveillance system. They were not analyzed in real time. They were not publicly reported during the adolescent vaccination campaign. We are publishing them now. Our study, published today in the International Journal of Cardiovascular Research & Innovation (led by @YaakovOphir, with @david_shuldman @NicHulscher and with @P_McCulloughMD), analyzes official Israeli adverse event reports that were not processed in real time. Using a deliberately conservative methodology, we identified at least 277 unique cardiovascular events among minors in 2021. 271 of these occurred in adolescents aged 12–16 — almost all within six weeks of eligibility expansion. Even under conservative assumptions, this corresponds to approximately one cardiac event per 939 vaccinated adolescents. This magnitude is orders of magnitude higher than established background rates of severe cardiac events in this age group, and markedly higher than the reassuring risk estimates presented to the public while the adolescent vaccination campaign was being promoted. The full paper is available here: reseaprojournals.com/journal…

INFARTOS: DADOS OFICIAIS DO SUS (AGORA COM 2025) Infartos EXPLODIRAM em jovens após as vacinas COVID-19. Internações até 50 anos. Com linha de tendência, para que não reste dúvidas. 2025 explodiu MAIS ainda. Mas não acredite em mim! Vou te ensinar a conferir. Segue o fio 🧶

📢 Vitamin C against septic acute kidney injury: randomized trial ✅ 64% reduction in acute kidney injury among vitamin C patients Vitamin C helps septic patients! imrpress.com/journal/IJVNR/9…