@markbrandonlab

Associate Professor and Neuroscientist at McGill University https://xitter.cf/t.co/xjzOfSHwLN https://xitter.cf/t.co/DmMYVJkUCP

 Montréal, Québec
markbrandonlab.com
Joined April 2017
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Now published @Nature, we used miniscopes to study the thalamic head direction system during drift and reorientation. Paper: nature.com/articles/s41586-0… Summary: douglas.research.mcgill.ca/n… There’s a lot in the paper, but my favorite piece to share/highlight is in figure 2:
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Changliang Guo@GuoChangliangOct 16
1/3 We built COMET (Cortex-wide Observational Miniature Epifluorescence Technique), a 3.75-g head-mounted mesoscope for cortex-wide, cellular-resolution calcium imaging in freely moving mice. φ10-mm FOV, single-cell resolution. biorxiv.org/content/10.64898… #neuroscience #miniscope
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Pleased to announce our new paper in @NatureNeuro, led by Robert Rozeske (former postdoc, now faculty at U of Toronto) and Léonie Runtz (former PhD student in the lab). Proud of both of them. nature.com/articles/s41593-0…

Overlapping representations in the ventral hippocampus support rapid fear memory retrieval

Nature Neuroscience - Fear learning increases the similarity of threatening and neutral context representations in ventral CA1, which may enable faster reinstatement of threat memories, compared to...

nature.com
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We imaged dorsal and ventral CA1 with miniscopes during a context fear "teleportation" task. After conditioning, vCA1 retrieved the threatening context faster than dCA1, and the balance between the threatening and neutral representations predicted freezing.
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To our surprise, conditioning also pulled the two context representations closer together in vCA1. That overlap may be what makes the switch to the threatening context so fast. Thanks to @McGill_VPRI @DouglasResearch @FondationDouglas @CIHR_IRSC for their support.
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Murayama lab, RIKEN CBS@mlab_cbsSep 15
Large-scale neural activity data across wakefulness, sleep, and anesthesia are now open. Includes EEG/EMG, brain states, Ca²⁺ traces, and spikes. Please download and play with the data! Cell Reports: doi.org/10.1016/j.celrep.202… Scientific Data: doi.org/10.1038/s41597-026-0…
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Takuya SASATANI
@takuyasasataniSep 14
Miniscope Zero, the first fully wireless Miniscope, is on @biorxivpreprint! Wireless power + data enable neural recordings in enclosed mazes, 3D environments & from two animals at once! @BroschMarcel @MiniscopeTeam Paper: doi.org/10.64898/2026.09.05.… Wiki: miniscope.org/wiki/Miniscope…
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Denise J. Cai, Ph.D.@denisejcaiJun 26
🎉 Congratulations to Zach Pennington on receiving this year's @BantingResearch Discovery Award! I worked closely with Zach when he was a postdoc in my lab and I know he is incredibly deserving of this award. Read more about his award here: psych.ubc.ca/news/zachary-pe…
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Julio Martinez@JulioMTNeuroJun 24
Not all neurons were created equal. Our marmoset cell type V1-LPFC resource is available and ready to serve the community. We used the same stimulation protocols as @AllenInstitute celltypes.brain-map.org/expe…, so the data can be compared to mice and humans primatedatabase.com/ephysCT.…
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A partial list of speakers for our 2027 Gordon Conference on Entorhinal-Hippocampal Memory Circuit in California is up! grc.org/entorhinal-hippocamp… Speakers, please retweet!! @brainrhythms @Serenadudette @pgolshani @Franklandlab @mazen_kheirbek @MacAskillAF @aa_fenton @LMPrida
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Denise J. Cai, Ph.D.@denisejcaiJun 8
🌎 Check out the new GLOBE tool that uses protein tape recorders to measure single-cell activity on a brain-wide scale. Congratulations to Changyang and team on developing and sharing this platform. Let us know what you think! biorxiv.org/content/10.64898…

Simultaneous brain-wide single-cell recording resolves spatiotemporal memory architecture

Many fundamental mammalian brain functions emerge from the coordinated activity of cells distributed across large, brain-wide networks. To understand these processes in healthy and diseased states,...

biorxiv.org
Changyang Linghu@ChangyangLinghuMay 22
Introducing GLOBE—a new technology for brain-wide, single-cell recording of cellular activity in vivo. GLOBE can continuously record from nearly a quarter million individual neurons simultaneously across a mouse brain. Preprint out on bioRxiv: doi.org/10.64898/2026.05.21.… 🧵(1/6)
Recording scalability in vivo

ALT Recording scalability in vivo

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St-Pierre Lab@StPierreLabMay 5
#MayThe4th be with you! Meet FORCE1s, a new positive‑going, ultrasensitive voltage indicator. Optimized for 2P imaging at slower acquisition speeds, FORCE1s is easy to use on almost any microscope. Bonus: it even powers 2P miniscope experiments!📄Preprint: biorxiv.org/content/10.64898…
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Sohan
@HiSohanMay 5
computational neuroscience has always known that real computation is spatial, temporal, and deeply non-linear. but for 30 years, simulating that reality meant relying on CPU-bound, non-differentiable tools. we built the engine to break that bottleneck.
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Paul Frankland@FranklandlabMay 4
Sharing the latest from the lab. Led by Yunlong Liu, this work explores how microglia and engram neurons interact during fear extinction in the hippocampus. rdcu.be/fgNH7
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Andrea Castegnaro@AndrCastegnaroApr 21
🧵 Our new review is out in @AnnualReviews of Neuroscience. We examine path integration in Alzheimer’s disease and ask what early navigational changes can reveal about the underlying brain circuits. Co-first-authored with Misun Kim and senior-authored by @NeilBurgess10 /1
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Attila Losonczy@attila_losonczyApr 14
New preprint from our lab on 3‑photon microscopy with deep, fast, Ca-imaiging on a large field of view. It started with @a_negrean and @tgeiller and was led by an outstanding student, Tiberiu Mihaila, with major collaboration with @DarcyPeterka. biorxiv.org/content/10.64898…
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Functional neuromics in 3D... honored to be part of this team!
Attila Losonczy@attila_losonczyApr 9
Excited about this project combining 2-photon imaging & spatial transcriptomics: biorxiv.org/content/10.64898… Lead scientist: @jason_hc_yong Collaborator: @erdem___varol Video: memorylongevity.org Website: memorylongevity.org/merscope…
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This is really incredible work, and opens up so many possibilities! Congrats @attila_losonczy @jason_hyun_yong and co-authors!
Attila Losonczy@attila_losonczyApr 9
Excited about this project combining 2-photon imaging & spatial transcriptomics: biorxiv.org/content/10.64898… Lead scientist: @jason_hc_yong Collaborator: @erdem___varol Video: memorylongevity.org Website: memorylongevity.org/merscope…
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Attila Losonczy@attila_losonczyApr 9
Excited about this project combining 2-photon imaging & spatial transcriptomics: biorxiv.org/content/10.64898… Lead scientist: @jason_hc_yong Collaborator: @erdem___varol Video: memorylongevity.org Website: memorylongevity.org/merscope…
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Giordano Lippi@LippiLabApr 7
The Lippi lab is hiring a postdoctoral associate! We built new technologies to study post-transcriptional regulation in the healthy and diseased brain. We are recruiting motivated and talented scientists who will use these tools to discover new biology and new therapies.
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Lisa Giocomo
@lisa_giocomoApr 1
New paper out @NatureNeuro! Congrats to @EmilyAeryJones & team! The brain doesn’t just map where you are, it maps where it matters. Entorhinal cortex represents important, distant reward locations. A step toward understanding how experiences are linked across space. rdcu.be/fbcS4
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