Neuroscientist, Geneticist/Genomicist and Computational Biologist

New York, NY
Joined March 2008
Las pruebas estadísticas clásicas son representaciones simplificadas de problemas de modelización. Si aprendea a especificar modelos estadísticos será más sencillo comprender qué está haciendo cada prueba, cuáles son sus supuestos y cómo extenderla cuando el diseño se complica.
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Edoardo Marcora retweeted
MIT published a brutally honest report on what AI is doing to students. A committee of professors and students spent five months studying how AI changed learning on campus, and the findings read like a warning to every university on the planet. Study groups are disappearing. Office hours are emptying out. Problem sets and take-home exams no longer prove anything, because AI can produce credible solutions to almost any written assignment in the undergraduate curriculum. Students who lean on chatbots lose mastery and confidence, and some slip into what the report calls cognitive surrender, reaching for AI at the first hint of struggle. The numbers are rough. 46 percent of surveyed MIT undergrads use LLMs daily. 90 percent worry about their own overreliance. Undergrads who feel AI makes them replaceable now outnumber those who feel it makes them capable. The committee's answer surprised me. They refused to fight AI with surveillance. The report calls AI detectors unreliable, says lockdown browsers feel like spying, and warns that policing students builds a classroom atmosphere of mutual distrust. Instead, MIT wants to rebuild education around the things AI can't replace. That means oral exams, semester portfolios, in-person project work, and a required social component in every subject. The report even floats the idea of rethinking grades entirely, since without a GPA to optimize, much of the incentive to cheat with AI evaporates. The committee warns professors against replacing undergrad research assistants with AI agents just because they're cheaper, because a university exists to grow people, not output. The most famous tech school on earth admitted the machines broke its way of teaching. Its answer is more humans, not more software.
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Edoardo Marcora retweeted
組織常在マクロファージのEP2受容体を阻害するだけで、心・脳・筋肉など複数臓器の老化指標が若返る 好中球は体内で最も数が多く、かつ最も短命な免疫細胞であり、通常は組織常在マクロファージ(Tissue-Resident Macrophages: TRMs)によって速やかに除去される。 しかし、この「掃除」の仕組みが加齢によってどのように変化するのかは明らかになっていなかった。老化は多くの臓器において並行して進行することが知られているが、その共通の引き金となる細胞メカニズムはこれまで特定されていなかった。 Tan、Andreassonらの研究チームは、老齢マウスにおいて組織常在マクロファージのプロスタグランジンE2受容体EP2のシグナルが活性化し、老化した好中球を捕食・処理する能力(Efferocytosis)が低下していることを見出した。 EP2を遺伝的あるいは薬理学的に阻害したところ、ミトコンドリア機能、認知機能、フレイル、筋肉量、心機能、全身性炎症といった幅広い老化指標が若返りの方向へ改善した。ヒトの加齢組織および疾患組織でも、同様のEP2発現上昇と老化好中球の蓄積が確認されている。 EP2はGタンパク質共役型受容体(Gs共役)であり、アデニル酸シクラーゼ-PKA経路を介してマクロファージのインテグリン依存的な老化好中球への接着とファゴリソソームでの分解処理を抑制する。 研究チームは組織常在マクロファージ特異的なCre-lox遺伝学的欠失と、選択的EP2拮抗薬PF-04418948の薬理学的投与という独立した2手法で同じ表現型改善を再現し、血漿プロテオミクス解析からは肝臓が加齢に伴う免疫変化の主要な発信源として浮かび上がった。 単一の分子標的によって複数臓器の老化指標を同時に改善できたという事実は極めてインパクトが大きく、老化を「受動的な劣化」ではなく「治療可能な細胞掃除の不全」として捉え直す新しい治療パラダイムを提示するものである。 science.org/doi/10.1126/scie…
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Have you gotten your FREE (for non-commercial uses, including Butlerian Jihad) PDF of Bayesian Workflow? The second half of the book is detailed case studies. avehtari.github.io/Bayesian-…
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Edoardo Marcora retweeted
#DAMPsPower!! Excited to share the 💥new 💥 @SciImmunology review that @marcodigioia & I wrote about the immunological activities played by host-derived oxidized lipids in controlling infections & tumorigenesis! doi.org/10.1126/sciimmunol.a…
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We've added to the website a free PDF of the Bayesian Workflow book (for non-commercial purposes, like research and exorcism). We put so much work into this book, hope you all find value in it. avehtari.github.io/Bayesian-…
The Bayesian Workflow book is out in print now, just in time to distract you from *gestures all around*. Some links below to code and other resources:
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🎉 Huge Congratulations to 2026 Mount Sinai Graduate Teaching Innovator Award Recipients @marcora, @angelaradulescu & Evan Schaffer! We can't wait for your project to come to fruition and to see the lasting impact it will have on graduate and medical education at #MountSinai! 👏
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Edoardo Marcora retweeted
Nel frattempo al confine tra Italia e Spagna. #ceuta
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Edoardo Marcora retweeted
🚨 Rep. Sarah Jacobs just left Pete Hegseth STUNNED in this hearing. With 2,500 Marines from her district off the coast of Iran and military families calling her office in panic, she asked the question no one else would : “Do you believe the president is mentally stable enough to be Commander-in-Chief?” Hegseth deflected hard. She didn’t flinch. Then she dropped this : “If you think this is what winning looks like… maybe we should be questioning your mental stability.” Pure accountability. No notes. It takes a woman to say what needs to be said when lives and billions of dollars are on the line. This clip is everything.
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Edoardo Marcora retweeted
Machines still don’t speak biology. A new Cell Perspective argues that bigger datasets, larger models, and more GPUs won’t automatically produce a universal model of life. The missing piece: process-aligned, causal world models connecting molecules, cells, tissues, space, and time. Biology is not just sequence. It is history, dynamics, and emergence. cell.com/cell/fulltext/S0092…
🤖 Made with AI
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Edoardo Marcora retweeted
I'm excited to announce that our study, Transcriptional regulation of disease-relevant microglial activation programs, has been published this morning in Neuron: cell.com/neuron/fulltext/S08…. We discovered functional regulators of six microglia activation states!
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Edoardo Marcora retweeted
Così parlò Zarathustra
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