macmylo retweeted
The pace of walking is another important factor of exercise w/r to a link with cardiovascular and all-cause mortality
Summary of findings from @uk_biobank large cohort study bjsm.bmj.com/content/early/2…
macmylo retweeted
Discovery of a 14-protein biomarker that predicts lung cancer 5.6 years before it is diagnosed, even in non-smokers, and an anti-inflammatory medicine that prevents its progression. And, challenging dogma, the proteins are not coming from cancerous cells!
macmylo retweeted
The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer.
✓ out the new Ground Truths (link in profile)
🤖 Made with AI
macmylo retweeted
We've written about AI-induced physician deskilling that has already surfaced
thelancet.com/journals/lance… @tberzin
AI-induced never-skilling among newly trained doctors, while not yet proven, is a serious concern that needs to be addressed @NatureMedicine @nliulab
nature.com/articles/s41591-0…
macmylo retweeted
The world’s most popular weight-loss and diabetes drugs are linked to a powerful new possible benefit: better outcomes for cancer patients. on.wsj.com/3RBfcXO
macmylo retweeted
ok so the rosie story was even more insane than it looked
> be the australian tech guy who made a cancer vaccine for his dog
> first try: genetic algorithms to design a new drug from scratch
> works in simulation but would take years to test
> second try: screen 1 million existing compounds against the mutation
> two weeks of computation. find a perfect match
> it's patented
> patent holder says no to compassionate use
> what_did_you_expect.jpg
> spend two weeks just being with the dog
> 2am idea: what if i just make a vaccine
> chatgpt for pipeline, gemini for construct, grok for validation
> 300 gigabytes of raw sequencing data to half a page of vaccine construct
> university ethics approval would take until mid-2026
> dog doesn't have that long
> panik
> canine cancer expert connects him to a lab in queensland with existing approval
> drive 14 hours to get there
> inject
> three weeks later the tumors swell. immune system swarming
> six weeks later shrinking
> two months later legs returning to normal
> one mass doesn't respond
> sequence it again
> different cancer. the vaccine worked. the body grew a new tumor
he's now building a company so every dog owner can do this
he had the technology the whole time. he spent 18 months fighting for permission to use it
macmylo retweeted
🚨BREAKING: MIT hooked people up to brain scanners while they used ChatGPT.
What they found should concern every single person reading this.
ChatGPT users showed 55% weaker brain connectivity than people who didn't use it. Not after years. After just four months.
Here's how they tested it. 54 people were split into three groups: one used ChatGPT to write essays, one used Google, and one used nothing but their own brain. They wore EEG monitors that tracked their brain activity in real time across four sessions over four months.
The brain-only group built the strongest, most widespread neural networks. Google users were in the middle. ChatGPT users had the weakest brains in the room. Every time.
Then the memory test hit. Participants were asked to recall what they'd just written minutes earlier. 83% of ChatGPT users couldn't quote a single line from their own essay. They wrote it. They couldn't remember it. The words passed through them like they were never there.
It gets worse. In the final session, ChatGPT users were told to write without AI. Their brains were measurably weaker than people who never used AI at all. 78% still couldn't recall their own writing. The damage didn't go away when the tool was removed.
Meanwhile, brain-only users who tried ChatGPT for the first time? Their brains lit up. They wrote better prompts. They retained more. Their brains were already strong enough to use AI as a tool instead of a crutch.
The researchers also found that every ChatGPT essay on the same topic looked almost identical. More facts, more dates, more names. But less original thinking. Everyone using ChatGPT produced the same generic output while believing it was their own.
MIT gave this a name: cognitive debt. Like financial debt, you borrow convenience now and pay with your thinking ability later. Except there's no way to pay it back.
The question isn't whether ChatGPT is useful. It's whether the price is your ability to think without it.
macmylo retweeted
Regular exercise is linked to substantially less time sick
In 1002 adults tracked for 12 weeks, exercisers ≥5 days/week had 43% fewer URTI days
Severity and symptoms were ~32-41% lower too.
macmylo retweeted
Daily use & high-THC cannabis are strong predictors of developing schizophrenia.
Cannabis from the 2000s is not the same as in 2026.
41.3% of young males with cannabis-induced psychosis develop schizophrenia within 3 years.
Readers added context they thought people might want to know
Misrepresents the findings. The findings are conditional on emergency room visit.
jamanetwork.com/journals/jamap…
macmylo retweeted
Exercise improves brain health, but can it also delay brain aging? In a randomized controlled trial, we show that moderate- and heavy-resistance training significantly reduced accelerated aging in brain clocks (estimated with fMRI). The effect is global and distributed, not confined to single brain hubs. Simple, scalable interventions can meaningfully shape brain clock trajectories in healthy aging. Move the body to slow the brain’s tick-tock. Congrats @rglezgz and the full team: Naiara Demnitz, Carlos Coronel, @TheilGates Michael Kjaer, @HSiebner & Carl-Johan Boraxbekk. #LISA team @GBHI_Fellows Paper: doi.org/10.1007/s11357-026-0…
Like to drink soda?) well... U heard it..;)
Common Sweetener May Damage Critical Brain Barrier, Risking Stroke : ScienceAlert share.google/vOeVhhw8Z9FaGrf…
macmylo retweeted
Coffee and improved cognition, reduced dementia
>130,000 people followed 37 years
Benefit seen only with caffeinated coffee or tea and most pronounced ~2 cups/day
@JAMA_current ☕️☕️jamanetwork.com/journals/jam…
macmylo retweeted
2 weeks without smartphone internet significantly improved sustained attention.
The effects were similar to being a decade younger.
macmylo retweeted
A review of the new trial results (below) along with all the other evidence and conclude it's time to move to AI-support for all mammography (with no cost to patients) erictopol.substack.com/p/why…
The largest randomized trial of medical A.I.
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lance…
macmylo retweeted
A success story for a physician with Alzheimer's which, in spite of the obstacles outlined, is a precursor for our enhanced ability to prevent the disease in the future
gift link
wsj.com/opinion/i-caught-my-…
macmylo retweeted
Repetitive negative thinking is associated with cognitive decline.
Repetition rewires the brain.
macmylo retweeted
The largest randomized trial of medical A.I.
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lance…
macmylo retweeted
Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts
1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below
macmylo retweeted
A randomized trial of using an LLM by primary care physicians for referral to specialists (vs no AI) provided substantial improvements in workflow, patient experience and less test ordering @NatureMedicine
nature.com/articles/s41591-0…

































