@m_mschaefer

PhD student @miriammerad @icahnmountsinai | BIF fellow | alumni @eth_en @sallustolab @becherlab @fu_berlin

 New York, USA
Joined August 2022
  • Tweets81
  • Following449
  • Followers127
3Media
Maximilian Schaefer retweeted
Florian Ingelfinger@FlorianIngelfi1Sep 30
CytoVI is finally out in @naturemethods! We introduce our first deep generative model built for immunologists working with cytometry data to mitigate some of the most pressing limitations of the technology! Grateful for the fantastic collaboration with @YosefLab & @IdoAmitLab
IdoAmitLab@IdoAmitLabSep 30
Different panels. Different technologies. Can we bring flow cytometry into biology’s AI revolution? Introducing CytoVI in @NatureMethods: linking cytometry & single-cell genomics to predict missing markers and reveal disease-associated cell states.🧵(1/15) doi.org/10.1038/s41592-026-0…
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Maximilian Schaefer retweeted
nature
@NatureSep 14
Nature research paper: A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion go.nature.com/4r3Zwdv

A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion

Nature - SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal...

nature.com
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I was such a blast to work on this project and I learned so much! Thank you to all the coauthors especially @ChiaraFalcomata and Bhavya Singh and Divya Chhamalwan! (3/n)
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A lot of cool tech went into this one, including Perturb-Map Multi-modal—a spatial CRISPR screen with dual Xenium-CyCIF readout, linking genetic perturbations directly to spatial immune phenotypes. (2/n)
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Excited to share our story on how SERPINs orchestrate local immunosuppressive niches in PDAC. Now out @Nature ! Spearheaded by @ChiaraFalcomata @Brown_lab1 @MiriamMerad @IcahnMountSinai @SinaiImmunol nature.com/articles/s41586-0… (1/n)

A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion

Nature - SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal...

nature.com
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Chiara Falcomatà@ChiaraFalcomataSep 9
Pancreatic tumors are highly heterogeneous and immunosuppressive. But is immune resistance imposed across the whole tumor - or built locally by distinct cancer-cell states? I’m incredibly excited to share our new paper, now out in @Nature! 🎉 doi.org/10.1038/s41586-026-1… (1/7)

A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion

Nature - SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal...

nature.com
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Maximilian Schaefer retweeted
Waggoner Lab@LabWaggonerSep 9
Cancer-derived SERPINE1 and SERPINB2 are local spatial organizers of immune suppression @Nature @IcahnMountSinai @ChiaraFalcomata @SinaiImmunol nature.com/articles/s41586-0…
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How do dendritic cells control tertiary lymphoid structures in cancer? Raphaël Mattiuz and @jboumelha just showed us how–just out in @ScienceMagazine. Happy I could contribute to this important piece. @MiriamMerad science.org/doi/10.1126/scie…

Dendritic cells control tertiary lymphoid structure development and maintenance in cancer

Tertiary lymphoid structures (TLSs) are associated with immunotherapy response, yet the mechanisms controlling their formation and maintenance remain unclear. Using spatial transcriptomics and...

science.org
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Maximilian Schaefer retweeted
Miriam Merad, MD, PhD@MiriamMeradJul 16
Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) science.org/doi/10.1126/scie…
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Congrats Flo 🎉 So exciting for the science that will come out of your lab!!
Ingelfinger Lab@ingelfingerlabJun 8
hello world. Excited to launch the Ingelfinger Lab account! We’re a young lab in Germany’s Black Forest tackling key questions in immunology with innovative single-cell technologies. Follow us for updates on systems immunology, machine learning & translational oncology. fi
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Maximilian Schaefer retweeted
Ingelfinger Lab@ingelfingerlabJun 8
hello world. Excited to launch the Ingelfinger Lab account! We’re a young lab in Germany’s Black Forest tackling key questions in immunology with innovative single-cell technologies. Follow us for updates on systems immunology, machine learning & translational oncology. fi
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