Research scientist, MRSN @WRAIR AMR genomic surveillance. MSc & PhD @LSHTM @SangerInstitute, PostDoc @MassEyeandEar @HarvardMed, @KlebClub fan!
Maryland
Joined April 2009
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Many years in the making - thrilled this is submitted! Convergence is driven by the acquisition of iuc and rarely results in phenotypic virulence. Complete with a one of a kind global Kpn plasmidome landscape and collection !
New preprint out! @AnjaliSapre @luluScience and co. mapped the evolutionary routes of convergence in K pneumo. Pop analysis of >1,400 global genomes & 7,500 closed plasmids to see how #AMR & virulence genes come together and impact phenotypes. researchsquare.com/article/r…
Thank you, Dr. Lee. It was great to share our work with the kleb community!
Brilliant talk from .@luluScience on profiling plasmids of global collection of Klebsiella pneumoniae to understand how resistance and virulence genes converge in a strain. #KLEBS2024
melissa j martin retweeted
Starting day 3 of #KLEBS2024 with a session on Genomics and Evolution with excellent presentations given by @daanensen , @OlayaRendueles , @luluScience , @bananabenana , Anna Weber
melissa j martin retweeted
Really excited to meet the #Klebsiella community in person! Thanks @sylvainbrisse & co for making this happen!
Dear #Klebsiella community: only one month to go before #KLEBS2024 We are looking forward to hosting you in Paris @institutpasteur . **Please do not forget to complete your registration very soon**. A très bientôt !
melissa j martin retweeted
Training workshop for our collaborators @NMRL Zimbabwe funded by @gatesfoundation to investigate the association of #typhoid with protists in wastewater but will have a positive impact for surveillance including #AMR Thanks to @tapfumamashe, @tweakyaustin, Michaela and Petros
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Our new paper with Tom Russo’s lab is out in @eBioMedicine We took out individual genes, combinations, or the whole virulence plasmid to measure their relative contribution in K. pneumoniae hypervirulence #hvkp @KlebClub sciencedirect.com/science/ar…
melissa j martin retweeted
New review article
WHO global research priorities for antimicrobial resistance in human health
thelancet.com/journals/lanmi…
#AMR #OpenAccess #OA
Looking forward to this one!!
Plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria dlvr.it/TBhYQS
Fantastic course, networking opportunity, and location! Highly recommend !!
Registration for the 2024 (Oct 19-27) ICARe course icarecourse.org is open until July 28. Be 1 of 40 selected participants and join Patrice Courvalin, @Faecal_flora, Heinz Moser and 30+ experts on #AMR and #drugdiscovery for a full week in #Annecy
icarecourse.org
melissa j martin retweeted
This is great paper and but I got to admit (though I am biased of course) not a single mention of the work done by DoD within the National Action Plan CARB program is a bit disappointing…
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I am very excited to share my newest article on virulence of #Klebsiella pneumoniae clinical isolates published today in @NatureComms. A big thank you to all of my co authors for their hard work! Including 5 grad students and 4 undergrads. #Microbiology
nature.com/articles/s41467-0…
melissa j martin retweeted
Fully funded PhD opportunity in my team; part of
@LSHTM, @NU_kouhou collaboration with Dr Daniel Inaoka and Prof. Toshio Kodama at Nagasaki Uni (tinyurl.com/yceavn38) dissecting the functions of the Campylobacter jejuni Type VI Secretion System (T6SS) effectors 🦠☕️🥼🧫👩🏾🔬🧑🔬
melissa j martin retweeted
Our latest paper is out in preprint! biorxiv.org/content/10.1101/… With routine WGS we detected an outbreak of MDR Pseudomonas with cases spanning > 10 years! Turns out contaminated sinks in ICU rooms were part of the problem. Cases are slowing down now.
SIX extensively drug resistant isolates recovered from an injured Ukrainian soldier including ST-395 K. pneumoniae that was non-susceptible to all antibiotics tested. Long read sequencing underway!! @Fr_Lebreton @Brendan67357746 Ting Luo Patrick McGann
wwwnc.cdc.gov/eid/article/29…
As of May 2023, our panel of 100 diverse Klebsiella pneumoniae clinical isolates have been requested and shipped to 151 academic and industry labs in 21 countries! @Fr_Lebreton @wrair (1/3)
Our paper describing these isolates/genomes for the research community was recently published in Microbial Genomics: microbiologyresearch.org/con… @Fr_Lebreton @wrair (2/3)
All isolates are FREE and can be requested from BEI Resources under catalogue #NR-55604 (beiresources.org). We are having fun seeing where they go! Stay tuned for more data on this panel! @Fr_Lebreton (3/3)
melissa j martin retweeted
Thrilled!
The #Klebsiella Diversity Panel ordered last weeek is already paying off .. the shipping costs!
We mined the genomes searching for a specific mutation which results in an interesting colony morphotype -similar to👇🏼👇🏼
from @schauflerlab 1/2
mdpi.com/2076-2607/10/10/206…
