@locusbearico

Researcher at @nyulangone @nyugrossman @NYUGSOM_Path | PhD at @IGBMC | MSc at @BtBsUNIMIB | 3D chromatin & melanoma. @locusbearico.bsky.social

 New York
Joined July 2023
  • Tweets125
  • Following172
  • Followers82
6Media
New preprint from the Hernando lab! biorxiv.org/content/10.64898… Combining 3D genome profiling and high resolution imaging we demonstrate how chromatin architecture cooperate with mechanical confinement in conferring melanoma mesenchymal cells high migratory capacities.
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Northwestern@NorthwesternUAug 29
The @NSF has awarded Northwestern $30 million to launch a center aimed at uncovering a hidden layer of information within the human genome. Scientists at the new center will harness cellular memory to combat injury, disease, aging and more. spr.ly/6016B1Fw3K

Northwestern to launch $30 million center to unlock genome’s hidden code

Scientists will harness cellular memory to combat injury, disease, aging and more

news.northwestern.edu
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nature
@NatureJul 10
Preprints don’t change much after peer review — and are rarely retracted. go.nature.com/3R05ZZj

Think preprints are unreliable? Analysis of 70,000 studies might change your mind

Nature - Central conclusions rarely change when biomedical preprints go on to be published in journals.

nature.com
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Our preprint describing the adaptation of the PIP-seq platform for scalable, inexpensive multiomics is now live on BioRxiv! Congrats to Zhifei Luo (@LuoZhifei)! biorxiv.org/content/10.64898…

A Simple, Cost-Effective, High-Throughput Method for Measuring Chromatin Accessibility and Gene...

We describe microfluidic-free, droplet-based methods for single-nucleus epigenomic measurements: Particle-templated Instant Partition single-nucleus assay for transposase-accessible chromatin using...

biorxiv.org
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Karreth Lab@KarrethLabJun 29
Check out our lab's latest preprint on a circRNA that promotes melanoma metastasis through cytoskeletal remodeling. Led by PhD student @NicolMecozzi circPMS1-mediated LIM protein scaffolding promotes cytoskeletal remodeling and melanoma metastasis biorxiv.org/content/10.64898…

circPMS1-mediated LIM protein scaffolding promotes cytoskeletal remodeling and melanoma metastasis

Circular RNAs (circRNAs) have been implicated in diverse biological processes and diseases such as cancer; however, their functional roles in tumor biology remain incompletely understood. Here, we...

biorxiv.org
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Our preprint was selected as top 1% by AI tool @qedScience among 57,455 @biorxivpreprint ! In some ways, it provides an objective measure of scientific merit than impact factors or other human-biased metrics. the-one-percent.qedscience.c…
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Richard Scolyer’s “final goodbye”, an open letter to all Australians smh.com.au/national/i-d-be-d…

I’d be delighted to be remembered as a proud everyday Aussie who ‘gave it a crack’

It was Richard Scolyer’s final wish that his passing be announced in his own words. This is his “final goodbye”, an open letter to all Australians that he penned before his final stages of illness....

smh.com.au
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David Adams@David_J_AdamsJun 7
A total legend and the nicest guy you could ever meet. We will miss you Rich. smh.com.au/culture/celebrity…

Former Australian of the Year Professor Richard Scolyer dies

The world-recognised pathologist survived for three years after being diagnosed with a savage form of brain cancer.

smh.com.au
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Dan Landau@landau_labJun 4
Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
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Elizabeth McKenna@ElizSMcKennaMay 21
ICYMI in @CD_AACR: A Targetable Developmental Program Co-Regulates Angiogenesis and Immune Evasion in Melanoma - by @locusbearico, Eva Hernando-Monge, and colleagues @nyulangone @nyugrossman @NYUGSOM_Path
Cancer Discovery@CD_AACRMay 15
Now online: A Targetable Developmental Program Coregulates Angiogenesis and Immune Evasion in Melanoma doi.org/10.1158/2159-8290.CD…
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I couldn’t be more proud of @FloresYanke, a super talented scientist freshly graduated in biomedical informatics @nyugrossman, which I have the privilege to co-mentor with Eva Hernando. Kudos Amanda!
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Elizabeth McKenna@ElizSMcKennaApr 21
For more on advances in basic science melanoma research by #AACR26 speaker Eva Hernando-Monge, check out her recent @CD_AACR paper: A Targetable Developmental Program Co-Regulates Angiogenesis and Immune Evasion in Melanoma doi.org/10.1158/2159-8290.CD… @nyulangone @NYUGSOM_Path
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Longzhi Tan@tanlongzhiApr 18
3D genome architecture underlies health & disease, but its biochemical basis is hard to study at scale. We present Plate-C: a screening platform that profiles thousands of whole-genome 3D maps in a day ($4 each), discovering many pathways that rewire DNA: biorxiv.org/content/10.64898…
Plate-C measures whole-genome architecture at scale

ALT Plate-C measures whole-genome architecture at scale

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Effie Apostolou@efapostolou29Apr 13
Excited to share our new paper in @NatureGenet led by the incredible @6jinLee! We uncover how cohesin loss impairs postmitotic refolding of 3D chromatin topology with limited context-specific effects on gene activation—especially during differentiation. nature.com/articles/s41588-0…

Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific...

Nature Genetics - Lee et al. deplete the cohesin component RAD21 in mouse embryonic stem cells. Most but not all chromatin loops fail to reform after mitosis, and transcriptional changes were...

nature.com
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What makes melanoma metastasize and can we predict it? Dr. Eva Hernando-Monge at NYU Langone's @Perlmutter_CC, is tracing the molecular signals and what they reveal about metastatic risk. Read more: nyulangone.org/news/investig… @locusbearico @NYUGSOMimcg @CD_AACR
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Support my DGR fundraising journey! I will be riding my Indian Chieftain with hundreds of others bikers to rise awarness on men's mental health and prostate cancer! gentlemansride.com/fundraise…

Pietro Berico | The Distinguished Gentleman's Ride

Support Pietro Berico's fundraising campaign. They've raised $416 so far!

gentlemansride.com
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Muchas gracias Oscar y @mtzsaid, @AlethiaAlvarez, @DorianGarciaMD del INCan por su gran apoyo,y @patydesu, @EstefVazque, @Christian_moli_ del @LIIGH_UNAM por liderar este proyecto!!! #cienciamexicana – at Querétaro, Querétaro Arteaga
Oscar Arrieta
@ogarrietaFeb 18
Publicación histórica 🇲🇽 en @Nature de @daniela_oaks y de su grupo de investigación en la @unam, en colaboración con diferentes instituciones como el @incanMX @mtzsaid, @CCINSHAE_mx @SSalud_mx felicidades a todos los autores e instituciones @inmegen #melanoma #Cancer
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Karreth Lab@KarrethLabFeb 10
Very excited that our new mouse model of #uveal #melanoma is now published at @CR_AACR. This model recapitulates the genetics and biology of human UM progression and will be a powerful tool for preclinical UM research.
Cancer Research@CR_AACRFeb 10
Now online: A Multi-Step Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma doi.org/10.1158/0008-5472.CA…
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Last but not least, thanks to our fundings from @NIH, @theNCI, @MelanomaReAlli, @CureMelanoma and @NCC_Org
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Thanks to our neighbors collaborators at @nyulangone, @Perlmutter_CC, @nyugrossman, @NYUGSOM_Path, particularly @jane_skok and @iannisaifantis1
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Thanks to the Backman Lab, our main collaborator from the @PhysGenCenter at @NorthwesternU!
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