With all of these biotechs getting funded and Anthropic and openAI and OpenEvidence getting into drug discovery, can someone tell me what the right “picks and shovels” play in biotech is ?
Even if Venture Capital funds are overvaluing everything and make no returns, at least they are taking money from the Middle East to fund the build out.
Middle East Oil > VC Funds > Tech employee Salaries, Founder Secondaries, Venture Capital Management Fees
Okay @david_protein and @PeterRahal you guys cooked with this. Better product than the bars. 10/10
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Everyone makes fun of Eight Sleep until it's 84º in SF and they don't have a liquid-cooled mattress. Suckers.
Yeah I’m sure they are really upset about the $12bn in gains @shaunmmaguire sourced from SpaceX
A massive miss for @sequoia who weren’t considered because @shaunmmaguire is a genocidal freak
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Replying to @Lewis_Bollard @Plinz
Also… it’s largely CHINESE interests that are pushing this. One of the biggest pro-gestation crate operators in the US is Smithfield foods, who are now China owned! It’s so nuts this has been allowed to get this far.
Timeline of Andrew’s journey through finance
Andrew Reed has quietly become one of the best growth investors of his generation. This is his first long form interview.
I talked to @andrew__reed about conviction under pressure, what great founders look like, and how humanity and competitiveness coexist inside @sequoia.
Andrew is a growth investor at Sequoia Capital, which he joined at 23. He led his first investment 4 years later into @RobinhoodApp, and he has partnered with @figma, @Klarna, @phantom, @VantaInc, @elevenlabs, @mubi, @Strava, and more.
We discuss:
- People over spreadsheets, every time
- Why great companies often have a few metrics screaming red and others screaming bright green
- Investing $200M into Robinhood during the first week of COVID
- How he developed conviction on Vanta in 14 seconds
- Why the hardest round to invest in is the one after you first invest
- Craft as a commercial input
- Writing memos through the night as a gut check on conviction
- why Sequoia's extreme performance culture is empowering
- What he's learned from Doug Leone, Mike Moritz, and Pat Grady
Timestamps:
0:00 - Opening Highlights
2:02 - Intro: Andrew Reed
3:50 - Thanks to Notion
5:23 - Start: Humanity, Spotting Weird, and Competitiveness
19:07 - Investing & Great Founders
37:53 - Andrew's Style, Pat Grady, and Continuous Learning
47:31 - Doubling Down and Not Flinching
56:09 - Empathy on Boards, Learning the Real Business, "Expensive" Prices, and Selling
1:07:18 - Managing Ego and Becoming a Leader
1:14:08 - Craft as a Commercial Input, Knowing vs. Feeling, Preparing for Big Days, Becoming a Great Closer
1:28:39 - Sequoia Capital
1:38:57 - Don Valentine, Mike Moritz, and Doug Leone
1:51:29 - Closing Questions
@DialecticPod Ep. 39: Andrew Reed - Don't Flinch - is out now, below and on all platforms.
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why not just raise income tax rates?
because your real intent is not to just “provide healthcare”.
you’re masking that you are proposing the creation of, for the first time in the 250 years of this American republic, an organized government seizure of private property from citizens.
you’re calling it a “wealth tax” or a “billionaires tax” or “millionaires tax” or whatever nom du jour polls well. but at the end of the day, it’s the seizure of private property from citizens by the government. citizens that earned money, paid their fair taxes on those earnings (53% if they live in California) and are now being told they need to hand over after-tax assets because the government has failed to provide promised services with the revenue it’s collected, and are now re-casting their own failure to be a socio-economic inequity that must be justly resolved... a slippery slope that has never gone anywhere good (see economic effects in USSR, Cuba, Venezuela, France and Norway wealth tax etc.)
the American founders fled tyranny in Europe and this amazing nation was populated by immigrants (myself and your parents) from around the world not just looking for a “better life” but for a place where they could have freedom from tyrannical governments that can take what they want from private citizens. a great nation borne of property rights, the rule of law, and endowed freedoms to believe, speak, or act. these principles led to the greatest run of innovations, successes, and widespread increase in prosperity, for all citizens, ever seen.
the citizens, the individuals, not the institutions, delivered this progress. those who invented, who toiled, who bled, who sacrificed, who took risk and persevered, who led, and who changed the world, are not charlatans, kleptocrats, or oligarchs. they’re what made us all better off. prosperity is a measure of america’s success, not its failure.
it is your principle that is so offensive, as evidenced by the broad disdain for your flippant flirtation with the darkest of human fantasy - socialism. you and other neo-socialists have led so many of us to reflect on America’s history and what it is becoming. that now leads so many to consider, so unnecessarily, leaving their homes for a place where everyone stands up to shout down the principle you suggest. because if your ideas are now considered moderate, it’s clear this titanic is sinking.
that a “simple tax” of taking assets that have been earned, through toil and tribulation, rightly taxed, and preserved, should now be unjustly seized, is your solution to a problem of obvious government mismanagement and outright fraud, tells us that your true motivation lies not in giving people healthcare but in cutting down success and deleting the system of prosperity and opportunity for all.
i don’t care, and neither should anyone else, what the sum total market value of a private citizens private assets might be. it is none of my business and should be none of yours. because, again, once you open that pandora’s box, we might as well study Lord of the Flies … there is literally nothing stopping 51% of citizens demanding that their government go out and seize 100% of the private property of the 49%.
want to give healthcare to people in need? do your job and fix healthcare. make it affordable. want to be lazy about it? then do your job lazily and raise income taxes.
want to take private property from private citizens who have paid their fair share of taxes and legally earned their property, then honestly declare that it is envy, not inequity, that you strive to resolve…
Okay I’ll admit it I just bought Christmas tickets for Marty Supreme. Generational run @RealChalamet e
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Please read the Count of Monte Cristo at least once in your lifetime.
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Tens of millions of people are turning to AI for health questions. Not because they think AI is smarter than a doctor—because it's a place they finally feel heard. It’s available 24/7, never rushed, and speaks plain language. But those conversations lack context and often go nowhere. They’re not connected to health history or to actual care.
General Medicine is changing that. Today we’re sharing a new way to connect feeling heard to getting care. We automatically gather your health history in one place where you can discuss with an AI chat that’s designed by our doctors to help summarize your health and figure out what should come next.
You can schedule exactly the care you need directly from your chat and your General Medicine doctor will review everything in advance. At your visit, they know exactly where to start.
You’ve almost certainly never seen your health story like this before. Try it, ask questions, get care you might be putting off, and share your feedback: Generalmedicine.co/ai
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Over the last year, we've 10X'd+ supply on our marketplace, powering tens of millions of dollars in bookings.
Today, we go a step further – enabling Wander to expand beyond the top 1% of vacation homes and service the entire industry (7M+ units) with the launch of Wander Sites.
Introducing Wander Sites
Today we're launching Wander Sites and putting our proven direct booking technology it in the hands of property managers around the world – empowering them to own their brand, bookings and guests.





















