@level3defless

NIG, Microbiology

Joined November 2015
  • Tweets1.6K
  • Following234
  • Followers364
92Media
Koichi Higashi retweeted
Kazuhiro Maeshima@kazu_maeshimaSep 18
🧬 Our “Behind the Paper” is now online at Springer Nature Communities: “Active chromatin is not simply open—it forms compact domains that cohesin keeps from mixing.” 📖 A short story behind our recent @NatureGenet paper. communities.springernature.c… nature.com/articles/s41588-0…
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Koichi Higashi retweeted
Kazuhiro Maeshima@kazu_maeshimaSep 8
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @NatureGenet reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗nature.com/articles/s41588-0… (1/2)
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Is euchromatin really “open”? 🧬Our new study @bioRxiv suggests otherwise. Using super-resolution imaging🔬　@shiori_iida @MasaAShimazoe reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. 🔗biorxiv.org/cgi/content/shor… (1/3)
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Our new paper is out @ScienceAdvances👇 science.org/doi/10.1126/scia… 🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells. 🔍@katsu_s_minami et al.have developed a chromatin behavior atlas within the nucleus. 1/2
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Excited to share our new paper @HCB special issue celebrating the Centennial of the Feulgen Reaction. bit.ly/3WDhiah My Ph.D. students @semeygazin @shiori_iida revealed behaviors of nucleosomes with mutated H4 in living human cells using single-nucleosome imaging. (1/2)
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Our new paper is out @Chromosoma_EB bit.ly/3TdIeeF My Ph.D. students @Aoi_Otsuka_ @katsu_s_minami studied chromatin organization/behavior in an oncogenic RAS-transformed mouse cell line. They found nucleosomes are more constrained in the transformed cells. Congrats!(1/2)
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Our new preprint is out @researchsquare: bit.ly/48z46FP My Ph.D. students @semeygazin @shiori_iida revealed behaviors of nucleosomes with mutated H4 (H4K16 point, H4K5,8,12,16 quadruple, tailless H4) in living human cells using single-nucleosome imaging. (1/2)

Behaviors of nucleosomes with mutant histone H4s in euchromatic domains of living human cells

Since Robert Feulgen first stained DNA in the cell, visualizing genome chromatin has been a central issue in cell biology to uncover how chromatin is organized and behaves in the cell. To approach...

researchsquare.com
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【研究成果】新しい研究成果を発表しました。■前島研究室（ゲノムダイナミクス研究室）/黒川研究室（ゲノム進化研究室）「ユークロマチンも凝縮した「塊」をつくっていた！」 👇論文（英語）はこちら doi.org/10.1126/sciadv.adf14… 👇解説記事（日本語）はこちら nig.ac.jp/nig/ja/2023/04/res…
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Excited to share our new paper @ScienceAdvances: bit.ly/3m6GG8y Dual-color imaging of two neighbor nucleosomes reveals that nucleosomes in euchromatin form condensed domains with ~150 nm diameter. Nucleosomes locally fluctuate in the condensed domain like a liquid. 1/
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Koichi Higashi retweeted
Chris Mason
@mason_lab27 May 2021
I'm elated to release four @metasub papers today, with new species, data interfaces, & online resources. The first is in @CellCellPress, "A global metagenomic map of urban microbiomes and antimicrobial resistance" led by @dcdanko @Daniela_Bezdan cell.com/cell/fulltext/S0092…" a 🧵 /1

A global metagenomic map of urban microbiomes and antimicrobial resistance

This systematic, worldwide catalog of urban microbiomes represents a metagenomic atlas important for understanding the ecology, virulence, and antibiotic resistance of city-specific microbial...

cell.com
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Inner workings of infant gut naturemicrobiologycommunity.… #behindthepaper #ismej #ismejournal #microbiology
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ゲノム進化研究室の東光一研究員、森宙史助教、黒川顕教授と共同研究を進めるトヨタ自動車未来創生センターから、研究成果の一端を紹介する記事が掲載されました。 toyota.co.jp/jpn/tech/partne… nig.ac.jp/nig/ja/research/or…

第2回Genki空間®研究の取り組み（後編）～新しい世界を切りひらく 空気質 研究～ | トヨタ | 未来につながる研究

トヨタの未来創生センターでは、パートナーロボットなど、新しい価値創造に取り組んでいます。その取り組み内容をご覧ください。

toyota.co.jp
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【研究成果】新しい記事を公開しました。■黒川研究室(ゲノム進化研究室)「乳幼児期の腸内代謝産物(短鎖脂肪酸)の産生に関与する腸内細菌と産生経路を確認」 nig.ac.jp/nig/ja/2021/03/res… doi.org/10.1038/s41396-021-0…
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This paper beautifully presents the dynamics of the gut microbiota and SCFAs in breastfed infants. Again confirming the dominant role of breast milk (HMOs) in dictating the development of microbiota and key metabolites in the gut👌🏻 nature.com/articles/s41396-0…

Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early...

The ISME Journal - Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early life

nature.com
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Social networks strongly predict the gut microbiota of wild mice @ISMEJournal by @AuraRaulo et al @sclknowles nature.com/articles/s41396-0…
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【お知らせ】5/22大学院一日体験会をオンラインで開催します。〆切：5/20(木)。各研究室フラッシュトーク、研究室見学(最大3)、現役院生との座談会を実施します。対象は学部生、高専専攻科生、修士院生など。大学院進学に興味をお持ちの方、気軽にご参加ください。 nig.ac.jp/nig-daigakuin/nig-…
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Bioinformatics over the years: 1990s: doing a BLAST search 2000s: analysing 30 microarrays 2010s: nalysing 6Tb of NGS 2020s: creating a cloud the size of Netflix to reanalyse the whole of SRA for one figure
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【お知らせ】TOKAIケーブルテレビさんに遺伝研の桜について取材いただいた内容が、ウェブで見られるようになりました。ドローンを使った上空からの映像もあります。ぜひご覧ください。 youtube.com/watch?v=BMWSphRj…
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【お知らせ】染井吉野が美しい”遺伝坂”から研究所の構内を探索する動画「国立遺伝学研究所 桜の旅」を作成しました。遺伝研の春を私たちと楽しんでいただけましたら幸いです。nig.ac.jp/koukai/koukai2020/ サイトでは桜などを順次公開の予定。たまにどうぞお立ち寄りください。 #国立遺伝学研究所桜の旅
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Bad News Wrapped in Protein: Inside the Coronavirus Genome NYT 🦠 ニューヨークタイムズ　新型コロナウイルスゲノム上の遺伝子配列(RNAなのでACGU)とコードされるタンパク質の構造と機能。まだ機能未知のものも。米ニュースメディアの科学リテラシーの高さに感銘　 nyti.ms/3bOm369

Bad News Wrapped in Protein: Inside the Coronavirus Genome (Published 2020)

The virus injects a tiny but remarkably complex strand of RNA into infected cells.

nytimes.com
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