Henry Lester (@lesterha) profile picture

Biophysics, neuroscience, #inside-out pharmacology. Recruiting students & postdocs at Caltech. Nicotine addiction. Pubmed: “lester ha”

Joined August 2011
I’m on IG also, leaterhahaha. Had nice 11-yr run here
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Going to mstdn in a week, due to the former guy. Uncertain where I’ll land on mstdn. Any advice?
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Allopregnanolone approved as rapidly acting antidepressant for post-partum depression. Congrats to friends JH Steinach, SR Grady, MJ Marks and AC Collins for leading early research showing allopregnanolone action on GABA-a and nicotinic receptors.
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Congrats to my brilliant, hardworking co-authors at Caltech, Janelia, and the University of Wisconsin.
Nicotine permeates into the ER where it begins an “inside-out” pathway that leads to addiction. Shivange et al. develop genetically encoded nicotine biosensors and show that nicotine and varenicline equilibrate in the ER within seconds of application bit.ly/2BiU7HS
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Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors jgp.rupress.org/content/earl…
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Neuroscience represents the wave of the future in many states and provinces, including several of Montana's neighbors. What a great investment! Surely Montana State would like to reconsider its decision to close this source of excitement, Federal funding, and medical advances.
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Henry's first tweet: I will teach "Drugs and the Brain" on Coursera in November.