
Biosecurity & AI @PerimeterBio. Following rationalists, biotech entrepreneurs, scientists & designers
New York
Joined January 2009
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Zachary Kurtz retweeted
Biosecurity global infra.
Beam is now available across platforms, with open weights under the Apache 2.0 license - in collaboration with an ecosystem of 40+ partners.
We're releasing:
- Weights, tokenizer, and reference implementation
- BF16, FP8 and NVFP4 weights and a DFlash2 drafter
- The open source harness we built and trained Beam on: Mirror CLI
Weights and model card on Hugging Face: huggingface.co/reflection
Zachary Kurtz retweeted
Replying to @StevenRianto @AndrewCurran_
If AIs figure out how to wirehead than humanity might survive this
Zachary Kurtz retweeted
Replying to @DeryaTR_
I get and agree with the argument at AI will lift prevention and cures as well as threats, but covid showed us already that - even with warp speed development- this is not symmetric and it lands in favor of threats
Zachary Kurtz retweeted
Replying to @Aizkmusic
People are now submitting artisanal, entirely human-driven proofs to arxiv and passing it off as an LLM
Zachary Kurtz retweeted
All in all -- to acquire and later via NBA sanctions -- Kawhi Leonard cost the Clippers:
2021 first round pick
2022 first round pick
2023 first round pick
2023 first round pick swap
2024 first round pick
2025 first round pick swap
2026 first round pick
2029 first round pick
2030 first round pick
2031 first round pick
2032 first round pick
2033 first round pick
Shai Gilgeous-Alexander, two time reigning NBA MVP
Danilo Gallinari
$30 million fine
Steve Ballmer suspended for one year
Lawrence Frank suspended six months
Gillian Zucker suspended one year
Leonard averaged 47 games in his seven seasons with the club.
Zachary Kurtz retweeted
our AI accelerator course starts on Saturday and I am really really excited for kickoff!
Day 1 is crazy, here's a quick summary of everything we're going to cover, I'd be happy to explain anything in the comments if you have questions!
Zachary Kurtz retweeted
There are only 15 true load-bearing stone triumphal arches the world. Rome built its last in 360 AD and another wasn't built for 1,000 years.
If triumphal arches are a sign of a civilization's peak, then Rome peaked in 117 AD, France in 1806, Prussia 1791, Russia 1814, Britain 1830, and the United States in 1915.
America built three in New York. It was the rise of the American Century. Then we stopped. 111 years ago.
Here's why: True triumphal arches are hard on purpose. Purely symbolic, they are a test of will to see if you can pull them off.
Take the Arch de Triomphe. Napoleon commissioned it in 1806. It took 30 years to build. Four monarchs and three architects passed before it was finished. Napoleon died in 1821 and never saw it completed.
The arch requires load-bearing stone. Typically limestone or granite which are easiest to cut. To build the arch, Napoleon opened a limestone quarry 100km south of Paris. It required 20,000 blocks, each weighing a ton to be extracted with hand chisels.
Each block must be chiseled to precision... by hand. A mason, who trained for 20 years, used mallets, chisels, and rasps to shape each block to millimeter tolerance. An arch, which is a physics trick and works by compression, will fail if a stone is just a few millimeters off. The force fails to flow evenly, pressure concentrates to a point, a stone cracks, and it fails.
America could still build a real one. The engineering exists. The stone exists. But we don't want open a quarry for a single monument. Stake 20,00 blocks by hand. We don't want to wait three decades while a project outlives the presidency that started it.
The Memorial Circle arch will cost $100M. It will be made of reinforced concrete and steel.
Is it emblematic of the United States today to build a symbolic triumphal arch, representing a 2,000-year-old test of will, only to fake it with steel rods and concrete?
one thing that really differentiates NYC from other cities is that you have lots of parts of the city where residents are high income but a majority don't own cars - almost all of which have a lot of transplants
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Zachary Kurtz retweeted
Today we’re launching American Wetware, a design studio for building with biology 🇺🇸💧
I’m doing this together with @thisischristina and @p_maverick_b
Our mission is to learn the design language of biology
Zachary Kurtz retweeted
We are looking for more hiring partners to join our internship program this semester!
Our students are engineers, CS majors, PMs, designers, data scientists, and consultants who use frontier AI tools every day. DM me or message me here if your company is interested.
I used to cover food and agriculture on Wall Street and I predicated this almost 10 years ago. Precise targeting of weeds and pests — making the use of chemicals unnecessary. Incredible to see it becoming reality.
Zachary Kurtz retweeted

Zvi Mowshowitz@TheZviMar 1
United States
United StatesConnected via United States Android AppAccount-level information, not a live location or per-post device.
Replying to @sama
I have a lot of Qs about this so please answer as much as you can, in priority order.
1) What forms of surveillance if any would your terms forbid, if the DoW determined they were legal? What is your definition of it that you believe is unconstitutional as per another Q? In particular, are you willing to do unlimited analysis of third-party or public information, which AIUI is considered legal? Of nominally 'constrained' private information? Is there an actual exception to 'all legal use' other than enshrining current law?
2) Can we see the rest of the contract, or at least the parts you claim tie it specifically to current law, or other parts of the defense in depth that you feel are key components?
3) What legal opinions did you get on your contract language before you agreed to it? Can you share any details? Did you consult with Anthropic's team to learn what their true objections were and why they felt they couldn't accept similar terms, and what particular language they were objecting to?
4) What is the enforceability mechanism? How will you know if DoW violates your redlines or does something illegal? If you do think so, what can you do about it? Does the safety stack include monitoring for patterns of activity like it would with another user? How much leeway does OpenAI have in designing its safety stack?
5) You said that this is more restrictive than Anthropic's previous contract, but that previous contract AIUI contained many more restrictions that they were offering to remove. How can you be confident you're right about this and if so why would DoW agree?
Zachary Kurtz retweeted
We are excited to partner with @Ginkgo Datapoints to demonstrate how Biomni can accelerate functional genomics analysis.
Biomni Lab analyzed 10+ transcriptomic and Cell Painting datasets from the Ginkgo Datapoints (GDPx) collection in hours instead of weeks, with results validated by Ginkgo scientists.
Try it today at biomni.phylo.bio and learn more at: phylo.bio/blog/ginkgo-biomni…
@jrkelly
Zachary Kurtz retweeted
35 protocols running simultaneously right now on our autonomous lab at @Ginkgo -- most we've done yet and RACs are the only lab automation stack in the world that can do this.
Especially love lots of protocols running as people go home for the night -- this is the future of lab work -- the lab runs while scientists sleep.
Really proud of the team for pushing the limits of hardware software and wetware to make this happen. Giving tours next week in boston if you want to see it in person, link below 👇
Zachary Kurtz retweeted
biotech-ml meetup on feb 11th in williamsburg!!! come!!! only a few spots left!!! quickly!!!!
Our Biotech x ML meetup (co-hosting with
@owl_posting and space donated by @fractaltechnyc)
has been featured on Luma's NYC's calendar. We had to cap registration and spots are going fast!
luma.com/jl9guyun
I might need a few extra volunteers to help set up, DM me!

































