@labgenex

🔬Neurobiology and Developmental Biology | 🧬Single-cell and Spatial Transcriptomics | @KubistaMikael | @IBT_CAS @BIOCEV_science @CzechAcademy 🇨🇿🇪🇺

 Biocev, Prumyslova 595, Vestec
labgenexp.eu
Joined November 2019
  • Tweets92
  • Following229
  • Followers236
28Media
Laboratory of Gene Expression retweeted
Zuzana Matúšová@ZMatusova17 May 2023
Happy to present our results at the Interdisciplinary meeting of young life scientists 2023 in the beautiful region of Žďárské vrchy! #milovy #science #conference
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We did a thing! "Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity" 👉 jci.org/articles/view/162253 Exciting data published in @jclinicalinvest Swedish-German-Czech collaboration🥂 @CzechAcademy @IBT_CAS
Lukas Valihrach@LukasValihrach17 May 2023
So happy to see this published in @jclinicalinvest!🥳🥂 Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity 👉jci.org/articles/view/162253 @uniofgothenburg @UKKoeln @CzechAcademy @IBT_CAS 🇸🇪🇩🇪🇨🇿 🧵1/8
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New paper published in our lab! ➡️ Cortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology ➡️ nature.com/articles/s41598-0… Great collaboration with Mirka Anderova group from IEM CAS🧠 Congrats to @ZMatusova @LukasValihrach and all authors involved👍
Lukas Valihrach@LukasValihrach21 Apr 2023
Happy to share our latest contribution to #ALS research🥳 Cortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology🧠 👉 nature.com/articles/s41598-0… #scRNAseq #astrocytes #microglia #oligodendrocytes @labgenex @IBT_CAS @BIOCEV_science 🧵1/5

Cortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology

Scientific Reports - Cortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology

nature.com
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Laboratory of Gene Expression retweeted
Microgenomics-2023@Microgenomics222 Apr 2023
Would you like to participate in @KubistaMikael workshop course on #methods & #strategies for #biomarker analysis? Take a look at the program & register today! microgenomics.symposium.inra…
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👇Happy to share our new review 👇 Reactive astrogliosis in the era of single-cell transcriptomics ➡️ frontiersin.org/articles/10.… Nice collaborative effort with @elly_hol🇳🇱 and Milos Pekny🇸🇪 #astrocytes #scRNAseq @IBT_CAS @BIOCEV_science

Frontiers | Reactive astrogliosis in the era of single-cell transcriptomics

Reactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central nervous system (CNS), accompanied by changes in astrocyte numbers, ...

frontiersin.org
Lukas Valihrach@LukasValihrach20 Apr 2023
Analyzing reactive astrocytes with scRNA-seq and need help with annotation and interpretation? Check our new minireview 👉frontiersin.org/articles/10.… Together with leading experts in astrocyte biology, we reviewed signatures of reactive astrogliosis across multiple CNS disorders🧵1/4

Frontiers | Reactive astrogliosis in the era of single-cell transcriptomics

Reactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central nervous system (CNS), accompanied by changes in astrocyte numbers, ...

frontiersin.org
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Congratulation to our teammates @ZMatusova and @DanielZucha for outstanding representation of our lab! 👏👏🥳 Also big thanks to the organizers for preparing such great event👍👍 Looking forward to the next one😉 @IBT_CAS @BIOCEV_science
Lukas Valihrach@LukasValihrach19 Apr 2023
Super-super proud of my two excellent PhD students, who received BEST TALK and BEST POSTER AWARDS at the first PhD student conference at @IBT_CAS and @BIOCEV_science 🥳👏🥳 Congrats and big applause for @ZMatusova and @DanielZucha from @labgenex 1/2🧵
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Another successful project between @PavlinkovaLab and @labgenex just published in Cardiovascular Diabetology👇 Dysregulation of hypoxia-inducible factor 1α in the sympathetic nervous system accelerates diabetic cardiomyopathy cardiab.biomedcentral.com/ar… @IBT_CAS @BIOCEV_science
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Back to Basics... Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action 👉 febs.onlinelibrary.wiley.com… @KubistaMikael @IBT_CAS @BIOCEV_science

FEBS Press

Evaluation of data reproducibility is a growing concern in many research areas. This is especially relevant when examining quantification methods of RNA profiling. The HEROIC consortium members...

febs.onlinelibrary.wiley.com
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🚨Preprint alert🚨 Proud to present this new study from our lab😆 Characterization of regeneration initiating cells during Xenopus laevis tail regeneration🐸 👉 biorxiv.org/content/10.1101/… @IBT_CAS @BIOCEV_science #scRNAseq #spatialtranscriptomics #Xenopus #regeneration #RICs
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🚨Preprint alert🚨 Very excited to share a new piece from our lab 🧠 Spatiotemporal transcriptomic map of ischemic brain injury 👉 biorxiv.org/content/10.1101/… @DanielZucha @LukasValihrach @AbaffyPali @kirdajka @IBT_CAS @BIOCEV_science

Spatiotemporal transcriptomic map of ischemic brain injury

The role of non-neuronal cells in the resolution of cerebral ischemia remains to be fully understood. To decode key cellular processes that occur after ischemia, we performed spatial and single-cell...

biorxiv.org
Daniel Žucha@DanielZucha29 Mar 2023
Dear Twitter, We are thrilled to share with you our most recent work - Spatiotemporal transcriptomic map of ischemic brain injury 🧠🤯 We looked at the first week of the injury, and we invite you to join us. A short thread🧵on what we found… 👇 biorxiv.org/content/10.1101/…

Spatiotemporal transcriptomic map of ischemic brain injury

The role of non-neuronal cells in the resolution of cerebral ischemia remains to be fully understood. To decode key cellular processes that occur after ischemia, we performed spatial and single-cell...

biorxiv.org
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Laboratory of Gene Expression retweeted
Lukas Valihrach@LukasValihrach28 Feb 2023
Thanks @IBT_CAS for highlighting our research😉 ....and stay tuned. We are just drafting our flagship manuscript providing brand new perspective on #AlexanderDisease pathology. More coming soon😉 @labgenex @rarediseaseday
Institute of Biotechnology
@IBT_CAS28 Feb 2023
Replying to @IBT_CAS
...and we are proud that some of the research on rare diseases is happening with us as well!👇 biocev.eu/en/about/news/an-i… @labgenex @KubistaMikael @LukasValihrach @ZMatusova 🧵2/2
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Laboratory of Gene Expression retweeted
Lukas Valihrach@LukasValihrach3 Mar 2023
👇happy to contribute to this study👇 β‐Lactoglobulin affects the oxidative status and viability of equine endometrial progenitor cells via lncRNA‐mRNA‐miRNA regulatory associations onlinelibrary.wiley.com/doi/… Congrats to authors and special thanks to Agnieszka😉@labgenex @IBT_CAS
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Laboratory of Gene Expression retweeted
Mikael Kubista@KubistaMikael14 Mar 2023
linkedin.com/posts/activity-…

Join my session in Freising on Next Generation sequencing! | Mikael Kubista

Join my session in Freising on Next Generation sequencing!

linkedin.com
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Laboratory of Gene Expression retweeted
Mikael Kubista@KubistaMikael14 Mar 2023
linkedin.com/posts/activity-…

Neogap and Simsen Diagnostics enter collaboration to improve personalised cancer diagnostics |...

Congratulations SimSen to new collaboration! Tour technology rocks!

linkedin.com
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Laboratory of Gene Expression retweeted
Elly Hol@elly_hol14 Mar 2023
There is an open call for post-doc fellowships (ZonMW dementia research). If you are interested in astrocyte-neuron interactions in dementia, have defended your thesis less than 5 years ago, and would like to work in my lab for 3 years...see tinyurl.com/yp534fvm or DM me.
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Well done👍 Congrats to all authors👏
Lukas Valihrach@LukasValihrach14 Mar 2023
👇So proud and happy to see this published 👇 ISL1 controls pancreatic alpha cell fate and beta cell maturation cellandbioscience.biomedcent… Great collaboration with @PavlinkovaLab and our first experience with CUT&Tag-seq🧬🥳 @labgenex @IBT_CAS @BIOCEV_science
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Laboratory of Gene Expression retweeted
Lukas Valihrach@LukasValihrach17 Feb 2023
Happy to contribute to this wonderful study “Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration” febs.onlinelibrary.wiley.com… and looking forward to next joint projects with Dasa Bohaciakova lab febs.onlinelibrary.wiley.com… 🧵1/3

FEBS Press

Modeling glioblastoma in vitro remains a major challenge. This study established a protocol for coculturing cerebral organoids and glioblastoma spheroids that allows studying the glioblastoma under...

febs.onlinelibrary.wiley.com
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Laboratory of Gene Expression retweeted
Institute of Biotechnology
@IBT_CAS13 Feb 2023
📝Still time to register for free @TATAA_CRO webinar on #qPCR and #dPCR led by @KubistaMikael @BIOCEV_science @CzechAcademy @labgenex #cellandgenetherapy #scienceeducation ⬇️⬇️⬇️
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Laboratory of Gene Expression retweeted
Lukas Valihrach@LukasValihrach10 Dec 2022
Thanks to @BIOCEV_science to highlight our work😊👍 Also thanks for all the support from @IBT_CAS and #GACR👏 @labgenex #miRNA #SCI 👇Scientists are looking for new ways to regenerate nerve tissue using microRNA molecules👇 biocev.eu/en/about/news/scie…
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Laboratory of Gene Expression retweeted
Lukas Valihrach@LukasValihrach2 Dec 2022
Very excited and happy to be awarded two #GACR grants to study experimental ischemic brain injury with #singlecell and #spatial #transcriptomics🥳🥂 @labgenex @IBT_CAS @BIOCEV_science gacr.cz/ga-cr-podpori-od-led…

GA ČR podpoří od ledna přes 500 nových vědeckých projektů - Grantová agentura České republiky

Ve své největší grantové soutěži Grantová agentura České republiky (GA ČR) od příštího roku podpoří 459 nových projektů ze všech oblastí výzkumu. Na tyto

gacr.cz
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