We focus on molecular and epigenetic mechanisms that regulate human stem cells, particularly hematopoietic, mesenchymal and induced pluripotent stem cells.
Aachen, Germany
Joined July 2018
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Aging is more than just a line. Instead of multivariate models epigenetic clocks can also be trained as a probablistic model on 2D-kernel density estimation: doi.org/10.1101/2024.06.10.5…
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There is a network between epigenetic clock sites! I am happy to share this preprint on our recent study: doi.org/10.1101/2024.06.04.5…
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Cancer shapes it microenvironment. Cancer associated fibroblasts #CAF become activated and reprogrammed and this is even reflected in their epigenome. We observed very similar changes in their DNA methylation pattern across different types of cancer.
biorxiv.org/content/10.1101/…
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Substrate elasticity impacts differentiation and the epigenetics of iPSCs? It does apparent not...
biorxiv.org/content/10.1101/…
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Proud to share this new preprint on cellular aging in myeloproliferative neoplasms. Our results indicate that cellular aging is accelerated in malignant MPN clones and this can provide a target for treatment with senolytic drugs or telomerase inhibitors.
medrxiv.org/content/10.1101/…
This week, our Institute for Stem Cell Biology had a Lab-Retreat in Trier. We had very stimulating discussions about science and future perspectives for research and lab-organization. IT REALLY IS A PRIVILEGE TO WORK WITH SUCH A FANTASTIC TEAM!!!
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YAP! It is essential!
It is a pleasure to share this work of Kira and coworkers demonstrating that YAP1 is essential for self-organized differentiation of pluripotent stem cells.
doi.org/10.1016/j.bioadv.202…
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We have an open PhD position on epigenetics in leukemia (myeloproliferative neoplasms). It rocks - please share @MPN @stemcells @leukemia @EpiExperts ukaachen.de/fuer-bewerber/st…
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Are your iPSC realy pluripotent? GermLayerTracker is a new biomarker to track differentiation toward endoderm, mesoderm, and ectoderm. This work was driven by three fantastic PhD students. cell.com/stem-cell-reports/f…
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If you are interested YAP, please have a look at our preprint. biorxiv.org/cgi/content/shor…
Hematopoietic differentiation remains possible in iPSC with #DNMT3A knockouts. We collected this data for more than 4 years and we are glad to now see it published at BMC Biology. Congratulations to Olivia and everybody involved.
bmcbiol.biomedcentral.com/ar…
Our new study on age-associated DNA methylation in mice was just published. There are marked differences between mouse strains.
frontiersin.org/articles/10.…
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Between murine mouse strains the methylome and age-associated DNA methylation may differ almost as much as between wild type individuals. biorxiv.org/cgi/content/shor…
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A brief review on how to translate DNA methylation biomarkers into clinical practice. doi.org/10.3389/fcell.2022.8…
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Imagine leukocyte counts with a simple finger prick. #EpiBloodCount can provide standardized analysis of leukocyte subsets from dried or frozen blood. academic.oup.com/clinchem/ad…
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Please check our new Biomaterials article. Congratulations Mohamed :)
doi.org/10.1016/j.biomateria…
DNMT3A knockouts in human iPSCs prevent de novo DNA methylation and reveal growth advantage during hematopoietic differentiation biorxiv.org/content/10.1101/…
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Stemcellbiology Aachen retweeted
We are looking for Ph.D. candidates to work on (1) bioinformatics for multi-modal single cell/spatial omics on kidney disease with @KuppeChristoph and (2) impact of age related DNA methylation on gene regulation with @lab_wagner . Details tinyurl.com/a9x47pjp . Please RT
In our latest publication we investigated if #DNAmethylation changes during in vitro cell culture are caused by epigenetic drift. Check out our new #epigenetics paper in @CommsBio
nature.com/articles/s42003-0…
We are proud to present our small contribution to the global efforts on #COVID19 research: our results indicate that #epigenetic #ageing is not accelerated in patients infected by #SARSCoV2. Check our new preprint here:
medrxiv.org/content/10.1101/…
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