Research group working at the interface of molecular epidemiology, computational biology and clinical medicine. Focus on inflammation, #lupus & #vasculitis
Imperial College London
Joined May 2021
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In 2025 we reported ⬆️ plasma tenascin-C (TNC) in large-vessel #vasculitis : (both GCA & Takayasu arteritis) : doi.org/10.1002/art.43110
Now in @JCI_insight Shi et al doi.org/10.1172/jci.insight.… show TNC is not just a marker of vascular injury but contributes to inflammation
biorxiv.org/content/10.64898…
Single cell resolution #eQTL mapping of immune cells (PBMC) in #lupus. Great collaboration with Sanger (Davenport and Trynka labs) and Tim Vyse at Kings College London through the OpenTargets partnership
Peters Lab retweeted
Sunday Spotlight💫: Presenting the most comprehensive proteomic map of systemic #Lupus erythematosus to date (>6000 proteins)! doi.org/10.1172/jci.insight.…
Geoffrey H. D. Leung @gleung23 James E. Peters @lab_peters & team @imperialcollege report potential therapeutic targets, biomarkers, and autoantibody-linked proteomic signatures in #SLE, providing a basis for precision medicine.
The figure shows SLE disease activity–associated proteins correlated with IFNL1.
@MedResFdn
🔬 Final version live in @JCIInsight:
Most comprehensive plasma #proteomic profiling in #lupus to date: >6,500 proteins, ~350 participants. Discovery of autoantibody-defined proteomic endotypes provides a basis for precision medicine
📄insight.jci.org/articles/vie…
Huge thanks to the study team, the patients & healthy volunteers who made this possible 🙏, and to @MedResFdn & @ImperialBRC for funding this work. Also a shout-out to the editorial team & Ken Beauchamp @JCIInsight for a superbly professional review and production process
Delighted that our study mapping the #proteome in #SLE is now published in @JCI_insight . Great work from the team especially grad student Geoffrey Leung
insight.jci.org/articles/vie…
-dsDNA autoantibody positivity is associated with ⬆️soluble CD40 ligand and ⬆️plasma proteinase-3
-In dsDNA +ve SLE: there's a positive association between sCD40L and disease activity
-In the dsDNA -ve group: NO association
Geoffrey Leung, PhD student from our lab, presenting his exciting work on #proteomic profiling in #lupus at #HumanImmune26. Preprint here: medrxiv.org/content/10.1101/…
Hopefully peer reviewed publication to follow soon...
Excellent perspective article on field of immunology. Why single cell atlases alone are not sufficient and the dangers of subspecialisation. We need to borrow some of the physics mindset rdcu.be/e3OtP
Delighted to be speaking at the Kennedy Institute of Rheumatology, Oxford @KirOxford outlining our research using #proteomics in immune-mediated diseases (#IMD) and proteogenomic studies in population-scale cohorts for insights into IMD aetiology
talks.ox.ac.uk/talks/id/ef1d…
Our multi-omic study on COVID19 in ESKD now published in @CellGenomics. Single-cell transcriptome, surface proteome and immunoreceptor sequencing of longitudinal samples, including paired pre-infection and acute infection samples sciencedirect.com/science/ar…
Blood protein profiles provide new insights into large-vessel vasculitis imperial.ac.uk/news/261093/b…
Peters Lab retweeted
Plasma @OlinkProteomics study of large vessel vasculitis spectrum revealed
•Highly similar proteomic signatures in Takayasu & GCA
•↑ Innate immune activation, and ↑ stromal remodeling
Results have implications for biomarker and drug design
In A&R
doi.org/10.1002/art.43110
ALT Schematic overview of study to investigate the plasma proteomic changes associated with each form of large-vessel vasculitis in two independent cohorts
Excellent series of immunology articles in @ACR_Journals covering complement, interferon signalling and SLE pathogenesis and CAR-T treatment:
acrjournals.onlinelibrary.wi…