UVA based cardiovascular research lab, SMC enthusiasts
Charlottesville, VA
Joined June 2018
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- Following143
- Followers456
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Congratulations to @beccadeaton and coauthors!
Dual lineage tracing reveals how irradiation impairs reparative vascular cell responses in advanced atherosclerosis to promote plaque instability @beccadeaton
@AnitaSalamon_
ahajrnls.org/4wWvwSR
Gary Owens Lab UVA retweeted
Mouse Model of Spontaneous Heart Attack and Stroke @sohelszaman @beccadeaton @lab_owens @UVACVRC @AnitaSalamon_ ahajournals.org/doi/full/10.…
Excited to see our publication in press @CircAHA complete with a fantastic editorial by @Const_Delwarde @AikawaAikawaLab . Our study was featured in this week’s Circulation on the Run podcast. Congratulations @sohelszaman, @beccadeaton and co-authors! ahajournals.org/doi/full/10.…
Thanks for the excellent summary of our recent work @HaoYin20 ! Congratulations to @sohelszaman and @beccadeaton and all their coauthors for this fantastic study. @UVACVRC
A mouse model of #Atherosclerosis (SR-BI∆CT/∆CT;Ldlr−/− + #WesternDiet) mimics late-stage events of human disease😎
👉75% #MyocardialInfarction
👉38% #Stroke
👉31% #PlaqueRupture
Similar lipid & liver enzyme profile to Ldlr-/-🐭except for 45% low HDL-C & body weight
Does this mouse have distinct SMC lineage trajectories from Ldlr-/-🐭? 😁
+Therapeutic effects of AZM198, myeloperoxidase inhibitor
AZM198->
⏫Sox9+Col2a1+ SMC subset (~5-fold!😮Re-thinking the role of the osteochondrogenic SMCs?)
⏫Contractile SMC subset
⏬Klf4+Egr1+ modulated SMC subset
@lab_owens @CircAHA 2024
ahajournals.org/doi/abs/10.1…
Congratulations to Dr. Karnewar and co-authors!
IL-1β promotes atherosclerosis but paradoxically is also required for diet-induced regression of advanced lesions and maintenance of a protective fibrous cap @InnovatieHester @gamze_b_bulut
@beccadeaton @DiezBenavente
ahajrnls.org/3KnnkV7
Gary Owens Lab UVA retweeted
IL-1β promotes atherosclerosis but paradoxically is also required for diet-induced regression of advanced lesions and maintenance of a protective fibrous cap @InnovatieHester @gamze_b_bulut
@beccadeaton @DiezBenavente
ahajrnls.org/3KnnkV7
One of our two newly funded projects!
Gary Owens, PhD, was awarded a $3.2 million grant to study the role of IL-6 trans signaling in atherosclerosis development, which can cause heart attacks and strokes. @UVACVRC @uvahealthnews #UVASchoolofMedicine news.med.virginia.edu/resear…
Gary Owens Lab UVA retweeted
February Featured Article: A new autosomal Myh11-CreERT2 mouse allows inclusion of both sexes in SMC lineage-tracing and gene-knockout mouse studies @gamze_b_bulut @Anita_Salamon_ ahajrnls.org/3Y3ZIJT
Today we celebrate the amazing women in the Owens Lab in honor of International Day of Women and Girls in Science @Anita_Salamon_ , Victoria Milosek, @beccadeaton , Noelle Koo, Alex Krinsky, Rupa Tripathi, Laura Shankman #internationalwomenandgirlsinscienceday #whorunstheworld
Gary Owens Lab UVA retweeted
A new autosomal Myh11-CreERT2 mouse allows inclusion of both sexes in SMC lineage-tracing and gene-knockout mouse studies @gamze_b_bulut @Anita_Salamon_
ahajrnls.org/3FzJjFs
We are excited to share our new autosomal Myh11-CreERT2 mouse model to enable smooth muscle cell specific KO & lineage tracing in both MALE & FEMALE mice!
(Previous 🐭 was Y-linked)
@atvbahajournals @beccadeaton
Gary Owens Lab UVA retweeted
A new study led by Dr. Gary Owens (@lab_owens) at @MedicineUVA has determined the function of Lgals3-transitioned inflammatory smooth muscle cells in #atherosclerosis.
📌 Read more: bit.ly/3QKMHCd
Gary Owens Lab UVA retweeted
🏆 Best of #NatMetab2021 | CITATIONS
#18
Exploring the origins of myofibroblasts in atherosclerotic fibrous caps, @lab_owens (@UVA), @aacnewman13 (@nyulangone), @DrVladPhD, @ScientistBaylis find that smooth muscle cells are required for plaque stability.
nature.com/articles/s42255-0…
Gary Owens Lab UVA retweeted
Many heart attacks and strokes are caused by unstable atherosclerotic plaques, which accumulate in our arteries. Researchers believe they could strengthen the plaque's fibrous caps and prevent these conditions. newsroom.uvahealth.com/2021/… @UVACVRC @AmericanHeartVA
