@lab_guo

The Guo Lab aims to understand the basic cell stress mechanisms associated with protein post-translational modifications in Health and Disease

 Sheffield, England
sheffield.ac.uk/bms/research/guo
Joined June 2019
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  • Following368
  • Followers173
2Media
Exciting news out of Professor David Chan’s lab! Their latest paper shares findings that are beautifully consistent with our previous work on FIS1-mediated mitophagy. cell.com/current-biology/abs…
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For fun: 'Mature SUMO' youtube.com/watch?v=GuOERAIX…

Mature SUMO

Licence & permissions. © 2025 HUI-JEN MIN. Published under the Stan...

youtube.com
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"PINK1 SUMOylation regulates basal mitophagy" biorxiv.org/content/10.1101/…

PINK1 SUMOylation regulates basal mitophagy

The detection and removal of damaged mitochondria is essential for cells to maintain a healthy mitochondrial network. PTEN-induced kinase 1 (PINK1) is a critical sensor that detects mitochondrial...

biorxiv.org
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To meet, learn and discuss: an exciting meeting for sure 😊 protein-degradation.org/symp…
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meetings.embo.org/event/25-s… EMBO Workshop SUMOylation: From discovery to translation 22 – 25 September 2025 | La Grande Motte, France I am sure this will be a good one😊.

SUMOylation: From discovery to translation

Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …

meetings.embo.org
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New Primary Research Publication from This Lab: 'SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia' nature.com/articles/s41419-0…
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This study, to our knowledge, is the first to investigate the role of protein SUMOylation in maintaining mitochondrial quality during hypoxia, a critical physiological stressor impacting cellular health.
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For the first time, global deSUMOylation, particularly deSUMO2/3-ylation, was shown to enhance basal and hypoxia-induced mitophagy, and FIS1-TBC1D17 interaction was observed at endogenous levels.
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nature.com/articles/s41419-0…

SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia

Cell Death & Disease - SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia

nature.com
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'we propose a novel SUMOylation-dependent pathway where the SENP3-FIS1 axis promotes HIM, with TBC1D17 acting as a fine-tuning regulator.'
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Happy to be part of the team 🥰 " ... C.G. first identified MFF as a SUMO substrate. . All authors contributed to editing the manuscript." Another set of evidence highlighting SUMO's regulatory function in mitochondrial fission science.org/doi/10.1126/scia…

SUMOylation of MFF coordinates fission complexes to promote stress-induced mitochondrial fragment...

A key molecular step is identified for the fragmentation and removal of damaged mitochondria that is essential for cell health.

science.org
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SENP3 knockout mice exhibit embryonic lethality at day 8.5, characterised by a neural tube defect and abnormal cardiac asymmetry (left-sided). sciencedirect.com/science/ar…
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MiDs - MFF - DRP1 actions in mitochondrial fission nature.com/articles/s41556-0…

Regulation of mitochondrial fission by fatty acyl-coenzyme A

Nature Cell Biology - We show that the mitochondrial fission proteins MiD49 and MiD51 are activated by fatty acyl-coenzyme A (FA-CoA). FA-CoA binds in a previously identified pocket located within...

nature.com
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"Overall, base editor screening of PTM sites provides a powerful platform to dissect PTM function within signaling pathways." nature.com/articles/s41592-0…
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Collaboration between the mitochondria and the nuclei in protein making cell.com/molecular-cell/full…
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The University of Sheffield Reviews by students studentcrowd.com/university-…
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"#1 out of 140 UK Universities"
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Chronic but not acute nicotine treatment ameliorates acute inflammation‐induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice - Wang - 2024 - CNS Neuroscience & Therapeutics - Wiley Online Library onlinelibrary.wiley.com/doi/…

Chronic but not acute nicotine treatment ameliorates acute inflammation‐induced working memory...

LPS significantly induced WM deficit accompanied by the increase in IL-1β and TNF-α in mPFC. Nicotine treatment significantly alleviated LPS-induced WM deficit by upregulating CREB-regulated transc...

onlinelibrary.wiley.com
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SENP3 again⁉️ 🧐 "In Alzheimer’s disease (AD), the BLA base model 654 identified seven AD-associated genes (DTX1, C3orf37, MEX3C, INPP1, USP32, YPEL2, SENP3)" biorxiv.org/content/10.1101/…

Common genetic variation impacts stress response in the brain

To explain why individuals exposed to identical stressors experience divergent clinical outcomes, we determine how molecular encoding of stress modifies genetic risk for brain disorders. Analysis of...

biorxiv.org
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link.springer.com/article/10…

Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1...

Cellular and Molecular Life Sciences - Obesity is characterized by chronic low-grade inflammation, which is driven by macrophage infiltration in adipose tissue and leads to elevated cytokines such...

link.springer.com
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