Associate Professor of Drug Discovery at the University of Wisconsin-Madison studying marine natural products, biosynthesis and metagenomics. He/him
Madison, WI
Joined July 2015
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Just voted in my first presidential election since becoming a US citizen! FYI if you are in Wisconsin you can vote early from today.
6/7 We've precomputed SocialGene databases of various sizes based on RefSeq, including one with over 2 million antiSMASH 7.0 predicted BGCs - one of the largest public BGC compendia to date! 📚🦠
7/7 Our interactive BGC atlas is now online (bgcatlas.pages.dev), featuring searches of >27,000 genomes associated with strains available from culture collections. Explore similar BGCs to each of the 2,502 BGCs in MIBiG! 🌐🔎 #GenomeMining #DrugDiscovery
2/7 We introduce SocialGene, a comprehensive software suite designed to collect, analyze, and organize multi-omics data into structured knowledge graphs. It can handle projects from small-scale to repository-scale analyses. 🧮📊
5/7 SocialGene is free, open-source, MIT-licensed, and designed for adaptability and extension. Check it out at github.com/socialgene 🖥️🔓
4/7 Key applications include targeted genome mining for drug discovery, accelerated searches for similar and distantly related biosynthetic gene clusters, and integration of chemical and analytical data. 💊🔬
3/7 SocialGene streamlines data ingestion, manipulation, aggregation, and analysis using Python and Nextflow libraries, culminating in a custom Neo4j database. It facilitates genomic synteny exploration and integrates diverse datasets. 🐍🔗
1/7 Excited to announce our new preprint on bioRxiv showcasing @ChasingMicrobes' SocialGene: biorxiv.org/content/10.1101/…
Excited to share our latest study on the traits controlling soil bacterial community reconstruction after prescribed burns! 🔥🦠 Check it out on BioRxiv: biorxiv.org/content/10.1101/… #Microbiome #SoilHealth #PrescribedBurns
Big thanks to my co-authors and everyone who contributed to this research. 👏🎉 #TeamScience #ResearchCommunity @SiddUppal @JamieWoolet @TheaWhitman, Ashley Tung and Charlie Yu from @MemVerge as well as ...
Muthusubramanian Venkateshwaran and Christopher Baker from @uwplatteville and Yari Johnson from the US Army Corps of Engineers.
Big thanks to @QuartzBenefits for forcing me to switch to a different insulin, which is now almost impossible to get hold of presumably because lots of other people were also switched. Eventually found one vial in an out of network pharmacy…
After calling all the pharmacies I could think of this morning. Was told by one pharmacist that quartz do not consider it a nationwide shortage so aren’t granting exemptions. @UWMadison I don’t think you are getting good value for money with this plan which wastes worker’s time.
Jason C Kwan retweeted
Is everything bigger in #Texas?? Me & @BradMoore_SIO are stoked to unveil the “PKZILLAs”: Genes for the new largest known enzymes and proteins in #biology, from the Texan fish-killing alga Prymnesium parvum. PKZILLAs make their giant 90-carbon polyketide toxin, prymnesin! 🧵1/n
