Neuroscientist @LieberInstitute using a cross-species approach to study cell type and circuit-specific gene expression changes in psychiatric disease.
Joined September 2019
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Kristen R Maynard retweeted
I’m excited to share my latest postdoc project with you all! This was a dream team collaboration co-led by Rita Cervera and @SvitlanaBach.
We also developed web apps that allow anyone to easily explore the data, found in the GitHub repo below 👇🏻
github.com/LieberInstitute/B…
26 years after Larry Swanson emphasized “the amygdala is neither a structural or functional unit” we used sn-RNAseq to answer the question:
“What is the [primate] amygdala?”
Check out the preprint 👇
biorxiv.org/content/10.1101/…
Kristen R Maynard retweeted
26 years after Larry Swanson emphasized “the amygdala is neither a structural or functional unit” we used sn-RNAseq to answer the question:
“What is the [primate] amygdala?”
Check out the preprint 👇
biorxiv.org/content/10.1101/…
Kristen R Maynard retweeted
Division of Translational Neuroscience @LieberInstitute will be at #SfN24! Presentations span mice, monkeys and humans from molecular to cellular through circuits and behavior. If you are interested in what we do, please stop by! @rehg_j @MicTott @R_Phillips_3rd @YufengDuYufeng
Kristen R Maynard retweeted
Bringing my account back to life just in time for #FluorescenceFriday with a peek at our preliminary dive into the human LC🔵in AD. Glials & microvessels surrounding tangles - let the adventure begin into their -omics! Major credit to @HeenaDivecha for the perfect slice!
Kristen R Maynard retweeted
Is your tissue larger than a @10xGenomics Visium capture area? If you need to stitch together the images but also the gene expression data, check our new preprint describing #visiumStitched
We also shared example postmortem human brain data (3 samples)
doi.org/10.1101/2024.08.08.6…
Kristen R Maynard retweeted
Our new microglia morphology pipeline tool is officially published in eneuro! eneuro.org/content/11/7/ENEU…
Kristen R Maynard retweeted
🚨Preprint alert🚨
Excited to share a commentary on opportunists and challenges in integrating spatially resolved #Transcriptomics (#SRT) data across tissues 🧠 and individuals 🧑🤝🧑!
Co-led with @WodanLing from @WCMPopHealthSci
🔗: arxiv.org/abs/2408.00367
🧵👇
Kristen R Maynard retweeted
So happy to share our latest preprint from the circuits team in @martinowk lab in collaboration with @GregCarrNeuro. Thanks so much to @SuhaasSAdiraju, @rehg_j and everybody that participated in this fun project. Now what's on the preprint.....
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test biorxiv.org/cgi/content/shor… #biorxiv_neursci
Kristen R Maynard retweeted
Very excited to share this new preprint led by the super talented @klbrida. We started by asking what marks drug-activated ensembles and stumbled onto a surprising answer that identified a key regulator of neuronal excitability and reward. A brief 🧵...
biorxiv.org/content/10.1101/…
Kristen R Maynard retweeted
Congratulations to all the Kavli NDI Distinguished Fellowship awardees. We are thrilled to support bold innovative transdisciplinary research, bridging #Neuroscience, #Engineering and #Data Science. @KavliFoundation @kishoreneuro @JEFworks @JustusKebschull @martinowk @kalhorlab
Kristen R Maynard retweeted
I'm very excited to share my first postdoc preprint with
@BoyiGuo and @stephaniehicks!
Here we preset SpotSweeper - the first spatially-aware quality control methods developed for spatial transcriptomics. 🧵
biorxiv.org/content/10.1101/…
Kristen R Maynard retweeted
Staff Scientist position available in our Division to manage operations in @LieberInstitute Imaging Core Facility. Responsibilities include providing training on and managing equipment as well as providing consultations on experimental design and image analysis.
Kristen R Maynard retweeted
Very happy to share that my big paper from my postdoc with @PaulKennyPhD is out today in Science! A few highlights below...
science.org/doi/10.1126/scie…
Kristen R Maynard retweeted
Very excited that my meta-analysis of telomere length GWAS and experimental validation showing that POP5 and KBTBD6 are human telomere length regulation genes is out in @NatureComms!
Shout out to my mentors @alexisjbattle and @RasikaMathias
nature.com/articles/s41467-0…
Kristen R Maynard retweeted
So happy I just presented one of my @LieberInstitute projects about transcriptomic changes in 🐀 rat #habenula and #amygdala 🧠 after chronic fentanyl self-administration 💉together with Ege Yalcinbas at the 2024 NIDA meeting. @NIDAnews
Thank you for inviting me @kr_maynard!
Kristen R Maynard retweeted
New paper on single-cell genomics & regulatory networks for 388 human brains just out in @ScienceMagazine. Neat stuff on single-cell QTLs, cell-to-cell communication, & DL models simulating drug effects (science.org/doi/10.1126/scie…) #PsychENCODE24
Kristen R Maynard retweeted
🔥 Hot off the press our paper on systems biology profiling of #PTSD and #MDD across brain 🧠, cell-types 🫧, and blood🩸 is out in @ScienceMagazine as part of #PsychENCODE24. Tap below for the full tweetorial by @NikosDaskalakis 💡science.org/doi/10.1126/scie…
💡Daskalakis & Ressler labs @McLeanHospital @harvardmed are extremely excited & proud 🥳to share that our collaborative work with Nemeroff @UTAustin and Kleinman @LieberInstitute labs on molecular underpinnings of #PTSD & #MDD is out @ScienceMagazine science.org/doi/10.1126/scie…! 🧵👇
Delighted to share that our data-driven molecular map of the DLPFC is now out in @ScienceMagazine as part of a collection of #PsychENCODE studies. Grateful for the opportunity to contribute to this collective effort to better understand the molecular basis of brain disorders.
New in @sciencemagazine: our work from @LieberInstitute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/science.adh1…
Kristen R Maynard retweeted
Very excited to share new work where we used #snRNAseq and #spatial #transcriptomics to better understand the molecular landscape of the human hippocampus (HPC)!
Huge thanks to Erik Nelson @CMM_JHU & @MadhaviTippani @LieberInstitute who led the work!
🔗 doi.org/10.1101/2024.04.26.5…
Congrats @MadenSean! Glad to be a part of this project!
1/🎉Ecstatic the lute software preprint with my mentor @stephaniehicks deconvolving sn & bulk #rnaseq of human brain is now on #bioRxiv! Thankful to @jhubiostat,@LieberInstitute, and my brilliant colleagues @lahuuki @sanghokwon17 @lcolladotor @kr_maynard 🎉tinyurl.com/lutePreprint