Klinman Lab @UCBerkeley @UCB_Chemistry. Hydrogen Tunneling, Protein Dynamics, and PQQ Biosynthesis.
Berkeley, CA
Joined November 2020
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Congrats to our undergrad Flora who will be starting her PhD in Chemistry at UCLA! @uclachem – at Berkeley, CA
Judith gave a phenomenal G.N. Lewis Memorial Lecture today on the Quantum and Classical Behavior in Enzyme Catalysis-her first in person lecture in 2 years! – at Berkeley, CA
Klinman Lab UCB retweeted
New insights into the mechanism of an enzymatic Friedel–Crafts alkylation from Nathaniel, Nate, and Cassidy! This was a wonderful collaboration with Terry and Kate from the Boal lab and Denise Okafor. Congratulations everyone!!! doi.org/10.7554/eLife.75761 @eLife
Klinman Lab UCB retweeted
My fearless team led by talented graduate student John developed a general method to solve structures of biologically reactive states: “Structure determination of high-energy states in a dynamic protein ensemble”@HHMINEWS @Nature nature.com/articles/s41586-0…
Klinman Lab UCB retweeted
Enhanced Diffusion and Oligomeric Enzyme Dissociation #JACSVirtualIssue #ChemistryinKorea pubs.acs.org/doi/10.1021/jac…
Klinman Lab UCB retweeted
Building on a library of hydroxylase-halogenase chimeras, Michelle Chang and colleagues @MChangGroup used reaction pathway engineering to switch a hydroxylase to robust halogenation activity. Free to read: rdcu.be/cDIjs. nature.com/articles/s41589-0…
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Check out our latest work on directed evolution. Best Kemp eliminase yet. researchsquare.com/article/r…
Klinman Lab UCB retweeted
De novo metalloprotein design
go.nature.com/2ZY6Fno
A Review article by Matthew J. Chalkley (@chalkley_talk), Samuel I. Mann (@simann13) & William F. DeGrado from @ucsfpharmacy @UCSF
Klinman Lab UCB retweeted
Proton-Coupled Electron Transfer Guidelines, Fair and Square #Electron #Transfer #ProtonCoupled pubs.acs.org/doi/10.1021/jac…
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OK. I'll say it. What are we to conclude from the all male @NobelPrize awards in #STEM these past two weeks?
1st. I'm sure the winners were all deserving. There's nothing to take away from them, and that is not my intention.
1/12
Klinman Lab UCB retweeted
A group of researchers have made the first direct observation of how the atoms within water molecules move when excited, a finding that may lead to a more accurate picture of how energy flows during chemical reactions. fal.cn/3i8tO
Check out Judith’s guest blog post on maintaining remote meetings for a more inclusive and sustainable science. nationalmedals.org/stories/r…
Klinman Lab UCB retweeted
I repeat- I haven’t been this excited about a discovery since CRISPR. We found something enigmatic that, like CRISPR, is associated with microbial genomes. We have named these unique entities #BORGs
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As the Fall semester is approaching, I would like to share our lab tutorials for students new to computational chemistry. liu-group.github.io/ It covers the essential things useful for a new student's Day 1 at a computational chemistry lab(1/3)
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Hey, people thinking about applying for the NSF GRFP! Here are some resources! And yes, first year grad student reading this and thinking "oh but that's not me", this means you! Kindly set the imposter syndrome aside for a second and read this thread! ❤️ (1/10)
Klinman Lab UCB retweeted
Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating 1 Iron Atom to Transform a [3Fe–4S] to a [4Fe–4S] Cluster by Zhang, Su, Dzikovski, @majorsmajer, @recoleman08, @biophyschemist, Fenwick, @crane_bc69, @Cupric4747, Freed, Lin @CornellChem in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
Klinman Lab UCB retweeted
🚨NEW PAPER🚨 It’s very hard to look at a cleft in a protein and predict if that cleft can do chemistry. Can we learn what the special sauce is that makes an enzyme active site catalytic? 1/ rdcu.be/cmIgr @natcomms
Congrats @nminneti! 🎉🎉🤔
A *belated* congratulations to the newest #BorovikLab PhD candidates, @nminneti and @atyounis561 🍾 keep crushing it! 💪🙌
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Read about this initiative in the Spring 2021 MCB Transcript:
mcb.berkeley.edu/news-and-ev…
Klinman Lab UCB retweeted
Our new preprint on multitemperature crystallography of SARS-CoV-2 Mpro is out! biorxiv.org/content/10.1101/… @DrAliEbrahim & @blake_riley took a detailed look at how Mpro reacts to being cooled/heated. We hope this helps ongoing antiviral design efforts (e.g. by @covid_moonshot).
