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Listen to "Code Green or Code Greed? Dr John Kellum" by The Critical Care Commute Podcast creators.spotify.com/pod/sho…
Do Microshit developers actually use their own products? Several updates ago (probably like 50 since they update ever 3 or 4 days) the made it so when you read a comment and then scroll down it will force you back to comment so that you lose your place in the doc thx @Microsoft !
John Kellum retweeted
Remote Ischemic Preconditioning: Is This Star Still Rising?
bit.ly/4crPbAV (FREE)
@kellumja @DanaFuhrman4
ALT Proposed mechanism of action for remote ischemic preconditioning. Multiple mechanisms for remote ischemic preconditioning have been suggested. A novel mechanism of action shown here involves high-mobility group Box-1 (HMGB-1) and possibly other molecules, released from muscle in response to transient ischemia. Transcriptomic imprinting of renal tubular epithelial cells occurs following signal transduction from engagement of HMGB-1 with Toll-like receptor 4 (TLR-4) on proximal tubular epithelial cells.
Somehow I missed this review from last March. Obviously, I think it's spot on!
Book Review: Code Green How the Big Lie in Healthcare Affects Us All by Kellum John - PMC share.google/OAuZO0Zgwb8wFGw…
How is possible that ICU physicians still believe that serum creatinine quantifies kidney function when nephrology adopted eGFR 20 years ago? How is it OK that a woman must lose 2.5x as much kidney function as a man just to get 1 SOFA point for renal? jamanetwork.com/journals/jam…
Another tripute to a giant in our field. Rest in peace dear brother. sciencedirect.com/science/ar…
Impact of propofol or sevoflurane on the renoprotective effect of remo... sciencedirect.com/science/ar… --This is a fascinating story. RIPC seems to work in some trials but not at all in others. Two big trials were negative so that's the end of story right? Not so fast. . .
...It turns out that the big trials used propofol and there is body of evidence showing that this agent blocks the protective effect of RIPC. Now with this paper we show how. Propofol interferes with the release of TIMP-2 and IGFBP7 from the kidney in response to RIPC...
Funny thing. . . 7% of patients with sepsis have "Nephrons of Steel" and don't develop Acute Kidney Injury when by all accounts they should. These "AKI-resistant" humans may hold the key to AKI prevention and therapy. doi.org/10.1186/s13054-025-0…
After more than 5 years and nearly 15,000 patients screened, main results from Tigris are out! Precision medicine isn’t for the faint of heart! PMX Hemoadsorption to remove endotoxin is highly effective in this very select population globenewswire.com/news-relea…
Learn why sepsis criteria are grossly inadequate for capturing Kidney dysfunction. Https://rdcu.be/eqH2N
As seen in other studies, about half of all patients admitted to the ICU develop AKI with about 2/3 stage 2-3. However only 12% of stage 2-3 are have persistent severe kidney dysfunction. Outcomes for these pts are far worse. Endpoint for drug trials?
rdcu.be/eebnP
doi.org/10.1016/j.jacc.2024.…
FACTCHECK “SGLT2 inhibitors result in “AKI” using KDIGO definitions yet confer undisputable benefits across a variety of settings.” FALSE
See et al. Makes a compelling Argument for Clinician Autonomy, and Individualized Care in the ICU. journals.lww.com/ccmjournal/…
We will never achieve our aspirations for a truly equitable society until those born into privilege see progress in absolute terms not just relative to people they believe they are superior to.
Kicking off Critical Care Nephrology precourse @ASNKidney week with Michael Connor. Thanks to course directors Ashita Tolwani and Mark Perazella
