@juazcue

🇦🇷 PreDoc at @TheSainsburyLab working on NLRs with @KamounLab 🌱🍄🦠. Racing Club de Avellaneda

 Norwich, England
Joined December 2016
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  • Following532
  • Followers160
4Media
Juan Azcue retweeted
Josh@JoshwbennettOct 16
Excited to share this bioRxiv where we characterise the interaction between the Magnaporthe Zinc finger fold effector (Tie1) to a family of rice transcription factors called the Tubby-like F-box proteins (TLPs)! biorxiv.org/content/10.64898…

A Blast Fungus Effector Targets a Tubby-like F-box Protein to Suppress Plant Immunity

The blast fungus Magnaporthe oryzae is one of the most destructive pathogens of rice, secreting effector proteins that reprogram host cells to enable infection. Identifying plant targets of these...

biorxiv.org
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Juan Azcue retweeted
Sophien Kamoun
@KamounLabOct 9
Farewell Maian @mai_garro for an incredibly successful postdoc before the PhD (aka predoc). Mai is moving next door to start a PhD in the renowned rotation program @JohnInnesCentre @TheSainsburyLab Thank you for your many contributions to our lab and research! 🔬 🧐 🧫 🌱 🇦🇷
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🍅 Tomato brown rugose fruit virus spread worldwide. For >60 years, one resistance gene protected tomatoes. This virus broke through. A second gene confers resistance. Same viral target? Convergent evolution? Preprint: biorxiv.org/content/10.64898… #EvoMPMI #NLRbiology (1/9) 🧵
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Excited to share this pre-print from my PhD work! We explore a Pmk1-Mst12-Bip1 network required for appressorium-mediated infection by the blast fungus 🌾 biorxiv.org/content/10.6... Thread 👇
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Juan Azcue retweeted
Andy Posbe@adnroideSep 10
Excited to share Fold on Tight! 🎉 We distil recent advances in plant immunity into 10 lessons for using AI structure prediction critically and effectively, in plants and beyond. With @amiralito_ Alex McClelland @YuSugiharaY @mpcontreras4 @KamounLab 📝zenodo.org/records/22100279
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Juan Azcue retweeted
Sophien Kamoun
@KamounLabSep 10
And now The J. Colhoun Poster Award Winner!
Sophien Kamoun
@KamounLabSep 10
You saw the poster—now hear the talk! Mauricio Contreras @mpcontreras4 with Maian @mai_garro and AmirAli @amiralito_ reveal the hidden handshake between sensors and helpers in the NRC network 🤝🌱 #BSPP26 #PPATH2026
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Juan Azcue retweeted
Maián@mai_garroSep 10
Great to present our work at #PPATH2026! How do sensor and helper NLRs talk? We uncovered a transient molecular handshake that activates helper — and determine which helpers a sensor can use 📌Poster doi.org/10.5281/zenodo.22206… @mpcontreras4 @amiralito_ @KamounLab @TheSainsburyLab
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One gene. No helper needed. 🌱🧬 We used AlphaFold 3 to discover single-gene NLR immune receptors in grasses 🌾 — then bioengineered SOLO1 to recognise a new target 🎯. #ECPP2026 #PPATH2026 📌 Poster below 🔗 doi.org/10.5281/zenodo.22671…
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Great to share this work with @YuSugiharaY 🚀 Come chat with us at #PPATH2026 about finding crop-native single-gene NLRs 🌾, AlphaFold 3 🤖, and bioengineering made-to-order plant immunity 🎯🛡️
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Juan Azcue retweeted
Sophien Kamoun
@KamounLabSep 7
Great mix of talks and discussions this morning kamounlab.dreamhosters.com/A…
Sophien Kamoun
@KamounLabSep 6
Kamoun Lab Alumni & Friends—warm-up event! kamounlab.dreamhosters.com/A…
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Juan Azcue retweeted
Racing Club
@RacingClubJul 15
EPTLPQLP 🩵🤍
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#SelecciónMayor SIMPLEMENTE GRACIAS JUGADORES!!!! 🥹😍🇦🇷 #TODOSJUNTOS
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Che, juega bien el pibito ese con el 10... Me gusta!
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So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵and link to the original preprint thread👇 science.org/doi/10.1126/scie…

Molecular mimicry of a pathogen virulence target by a plant immune receptor

Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect...

science.org
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Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇 biorxiv.org/content/10.64898…
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Juan Azcue retweeted
AmirAli Toghani@amiralito_May 5
Protein structure prediction changed biology. Protein assembly discovery is next. We present SNI (Structural Novelty Index), a scalable framework for finding new protein complexes. We used it to uncover an unexpected resistosome assembly: 11-mer. 🧵👇🏻 biorxiv.org/content/10.64898…
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AI-guided discovery of atypical protein assemblies biorxiv.org/content/10.64898… So far, we’ve seen 5-mers, 6-mers, & 8-mers, but now it’s an 11-mer! A cool surprise from the NRC network on resistosome organization. Congrats to @amiralito_ Ben @daniel_luedke & the @KamounLab 👏✨💐
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We are happy to celebrate @mpcontreras4 winning the @BiochemSoc 2027 Early Career Research Award! Mauricio joined TSL as a predoc in the @kamounlab, where he did his PhD and postdoc before starting his own group at @ZMBP_Tuebingen. Congrats Mau! 🏆 tsl.ac.uk/news/tsl-alumnus-w…

The Sainsbury Laboratory | TSL Alumnus wins Biochemical Society Award

tsl.ac.uk
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Juan Azcue retweeted
Sophien Kamoun
@KamounLabFeb 19
It’s that time of year! #SchoBozKa in Downing College, Cambridge 🇬🇧 Running strong since 2017–Annual lab meeting of the teams of Sebastian Schornack, Tolga Bozkurt, Lida Derevnina, Phil Carella, Jiorgos Kourelis and Sophien Kamoun. This year’s guest is Steven Spoel, University of Edinburgh
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Juan Azcue retweeted
Sophien Kamoun
@KamounLabJan 23
New Year Lunch 2026 @KamounLab Burma New Zealand Germany Italy Iran Tunisia USA United Kingdom Argentina France Japan Thailand Netherlands Australia China
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